Biomimetic synthesis of needle-like nano-hydroxyapatite templated by double-hydrophilic block copolymer

Yao, Xiang; Hong-wei, Yao; Li, Guoying; Li, Yuanting

doi:10.1007/s10853-009-4182-4

Cited by 34 publications

(28 citation statements)

References 20 publications

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“…A more precise problem [47] stands in line with this way of thinking: "Focusing on nano-HAp morphology, needlelike [48][49][50][51] and platelike [52][53][54] nano-particles can be prepared, while in bone tissue only the second type seems to be present [55][56][57]. For both morphologies the prevailing surface terminations are of the {010} type, which in the case of needlelike nano-HAp are the lateral facets of the hexagonal nano-particles elongated along the crystallographic c-axis, while, for the platelike nano-particles they are the basal facets of nano-particles preferentially grown along both the c-and a-(or b-) axis [53,54,58] breaking the crystal symmetry through a mechanism still matter of investigation [52,58].…”

Section: Solved and Unsolved Problems About The Relationship Between mentioning

confidence: 95%

About the Genetic Mechanisms of Apatites: A Survey on the Methodological Approaches

2017

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Apatites are properly considered as a strategic material owing to the broad range of their practical uses, primarily biomedical but chemical, pharmaceutical, environmental and geological as well. The apatite group of minerals has been the subject of a huge number of papers, mainly devoted to the mass crystallization of nanosized hydroxyapatite (or carboapatite) as a scaffold for osteoinduction purposes. Many wet and dry methods of synthesis have been proposed. The products have been characterized using various techniques, from the transmission electron microscopy to many spectroscopic methods like IR and Raman. The experimental approach usually found in literature allows getting tailor made micro-and nano-crystals ready to be used in a wide variety of fields. Despite the wide interest in synthesis and characterization, little attention has been paid to the relationships between bulk structure and corresponding surfaces and to the role plaid by surfaces on the mechanisms involved during the early stages of growth of apatites. In order to improve the understanding of their structure and chemical variability, close attention will be focused on the structural complexity of hydroxyapatite (HAp), on the richness of its surfaces and their role in the interaction with the precursor phases, and in growth kinetics and morphology.

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Section: Solved and Unsolved Problems About The Relationship Between mentioning

confidence: 95%

About the Genetic Mechanisms of Apatites: A Survey on the Methodological Approaches

2017

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“…[89,100,226,511,631,735,789]. Furthermore, similar terms "nano-HA" [103,575,608,659,681,692], "nano-hydroxyapatite"[42, 87,91,92,96,97,102,119,190,191,294,295,314,338,451,459,486,492,578,583,606,627,628,641,664,666,677,682,685,687,693,698,701,703,705,770,773], nano-fluorapatite [104,684] and "nanohydrox...…”

Section: Post-conclusion Remarksmentioning

confidence: 99%

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin¹

2012

AJBE

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Nano-sized particles and crystals play an important role in the formation of calcified tissues of various animals. For example, nano-sized and nanocrystalline calcium orthophosphates in the form of apatites of biological origin represent the basic inorganic building blocks of bones and teeth of mammals. Namely, according the recent developments in biomineralization, tens to hundreds nanodimensional crystals of a biological apatite are self-assembled into these complex structures. This process occurs under a strict control by bioorganic matrixes. Furthermore, both a greater viability and a better proliferation of various types of cells have been detected on smaller crystals of calcium orthophosphates. Thus, the nano-sized and nanocrystalline forms of calcium orthophosphates have a great potential to revolutionize the hard tissue-engineering field, starting from bone repair and augmentation to controlled drug delivery systems. This review reports on current state of the art and recent developments on the subject, starting from synthesis and characterization to biomedical and clinical applications. Furthermore, the review also discusses possible directions for future research and development.

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“…A prerequisite for a potential bioactive material is the formation or growth of HA on the surface of the material once in contact with body fluids [2]. HA is the basic component of natural bone [3]. It is now accepted that materials capable of forming this bone-like apatite in SBF will likely bond directly to bone upon implantation [4].…”

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite formation on metallurgical grade nanoporous silicon particles

2010

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Studies into bone-like apatite or hydroxyapatite (HA) growth on potential biomaterials when in contact with simulated body fluid (SBF) not only establish a general method for determining bioactivity but coincidently lead to the design of new bioactive materials in biomedical and tissue engineering fields. Previous studies of HA growth on porous silicon have examined electrochemically etched silicon substrates after immersion in a simulated body fluid. This study differs from previous work in that it focuses on characterising HA growth on chemically etched metallurgical grade nanoporous silicon particles. The porous silicon (PS) used in this study is comprised of nanosponge particles with disordered pore structures with pore sizes ranging up to 10nm on micron sized particles.The silicon particles are analysed before and after immersion into SBF using scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive x-ray (EDX) analysis and x-ray photoelectron spectroscopy (XPS). Results indicate that a HA layer forms on the surface of the nanosponge particles. Experimental analysis indicates that the morphology and calcium-tophosphorus ratio (Ca/P) verify the formation of crystalline HA on the nanoporous silicon particles.2

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Biomimetic synthesis of needle-like nano-hydroxyapatite templated by double-hydrophilic block copolymer

Cited by 34 publications

References 20 publications

About the Genetic Mechanisms of Apatites: A Survey on the Methodological Approaches

About the Genetic Mechanisms of Apatites: A Survey on the Methodological Approaches

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Hydroxyapatite formation on metallurgical grade nanoporous silicon particles

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