Biomimetics: Platelet‐Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury (Adv. Funct. Mater. 4/2019)

Su, Teng; Ma, Hong; Liang, Hongxia; Dinh, Phuong‐Uyen; Shen, Deliang; Allen, Tyler A.; Qiao, Li; Li, Zhenhua; Hu, Shiqi; Cores, Jhon; Frame, Brianna N.; Young, Anthony; Yin, Qi; Liu, Jiandong; Li, Qian; Caranasos, Thomas G.; Brudno, Yevgeny; Ligler, Frances S.; Cheng, Ke

doi:10.1002/adfm.201970019

Cited by 3 publications

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“…The tasks about targeted heart repair have also been carried out through biomimetic strategies by Cheng et al. [ 256 ] They have designed platelet‐inspired nanocells (CS‐PGE 2 ‐PINC) consisting of resident cardiac stem/stromal cells and prostaglandin E2(PGE 2 )‐modified platelet membrane ( Figure ). Different from natural stem cells, CS‐PGE 2 ‐PINC possessed injured blood vessels and cardiomyocytes dual‐targeting performance in ischemia/reperfusion injury, and achieved the synergistic treatment efficacy through the combination of PGE 2 –PGE 2 receptor signaling and paracrine mechanism of cell therapy.…”

Section: Biomimetic Tissue Engineeringmentioning

confidence: 99%

Nanobiomimetic Medicine

Chang

Dong

Huang

et al. 2022

Adv Funct Materials

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The application of nanotechnology in medicine aims at developing the precise theranostics of diseases by leveraging the extraordinary effects of engineered nanomedicines, materdicine, and biomaterials. However, finely controlling the biological behavior of nanomaterials in the complex living systems remains a great challenge in terms of accuracy and intelligence. Inspired by nature, biomimetics has become an attractive strategy based on the highly ordered natural biological structure for the development of clinically valuable materials and technologies, arising from the superior bioavailability. The rapid development of biomimetics in nanomedical applications prompts the authors to propose the concept of “nanobiomimetic medicine”, which is a considerable subdiscipline in nanomedicine and materdicine that applies the concept and strategies of biomimetics to facilitate and promote the disease theranostics. Herein, the authors aim to furnish a state‐of‐the‐art review on the latest progress in the field of nanobiomimetic medicine. The design strategies, structural features and biological properties of biomimetic materials are initially introduced to reveal the inherent bionic mechanism and the potential structure‐function relationships. Furthermore, advances with respect to the applications of diverse biomimetic materials are comprehensively summarized. Finally, the current challenges and future direction of nanobiomimetic medicine are discussed and prospected in order to stimulate more biomimetic fundamental and technological breakthroughs in nanomedicine.

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Section: Biomimetic Tissue Engineeringmentioning

confidence: 99%