Biomonitoring chronic lead exposure among battery manufacturing workers in Tunisia

Nouioui, Mohamed Anouar; Araoud, Manel; Milliand, Marie-Laure; Bessueille-Barbier, Frédérique; Amira, Dorra; Ayouni-Derouiche, Linda; Hédhili, Abderrazek

doi:10.1007/s11356-019-04209-y

Cited by 21 publications

(12 citation statements)

References 54 publications

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“…The method relies on direct analysis of Pb in blood and urine via a simple dilution in a chemical modifier mixture without previous acid digestion as described by Nouioui et al. (2019). Blood samples were 20‐fold diluted with a mixture of 0.1% (v/v) Nitric acid (Merck) HNO 3 + 0.5% (v/v) Triton X‐100 (Scharlau) + 0.2% (v/v) Anhydrous di‐ammonium hydrogen phosphate (NH4)2HPO4 (Fluka Analytical).…”

Section: Methodsmentioning

confidence: 99%

“…Twenty microliter of the consequent sample was delivered into the pyrolytically coated graphite tube. Because of the high background signal, levels of blood and urinary Cd were measured in the presence of a mixture of Pd/Mg (NO3)2 (22 µg of Palladium (Pd) (Fluka Analytical)/8 µg of Magnesium (Mg) (Fluka Analytical) for blood and 27 µg Pd/7 µg Mg for urine) injected with the sample as a chemical modifier (Nouioui et al., 2019).…”

Section: Methodsmentioning

confidence: 99%

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Effects of lead, cadmium, copper and zinc levels on the male reproductive function

Chabchoub

Nouioui²,

Araoud³

et al. 2021

Andrologia

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This study aimed to investigate the effects of heavy metals on measures of male fertility. One hundred and two infertile men with occupational exposure and thirty fertile men were included in this study. Blood and urinary levels of lead, cadmium, zinc and copper were measured by atomic absorption spectrophotometry. Semen parameters and a motile sperm organelle morphology examination were also performed. Measures of hormonal levels, oxidation–reduction potential, DNA fragmentation index and chromatin condensation were assessed for all participants. Heavy metals levels, oxidative stress and DNA quality were significantly higher in the infertile group compared to controls. FSH and testosterone levels were lower in the infertile group. A urinary cadmium level was positively associated with abnormal sperm morphology (r = .225, p < .05). Normal morphology was inversely correlated with the duration of the exposure (r = −.227, p = .022). The blood lead level was positively related to the level of testosterone (r = .223, p = .031). Cadmium and lead blood levels were positively correlated with the level of chromatin decondensation (r = .528, p < .001; r = .280, p = .017). Our study showed that occupational exposure to heavy metals is very harmful to reproductive health. DNA quality and oxidative stress investigations must be recommended for reprotoxic exposed patients prior to in vitro fertilisation treatment.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Effects of lead, cadmium, copper and zinc levels on the male reproductive function

Chabchoub

Nouioui²,

Araoud³

et al. 2021

Andrologia

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“…Blood is the preferred matrix for biomonitoring of Pb exposure. It is in continuous contact with the whole organism and in equilibrium with all organs where Pb is stored (Esteban and Castano 2009;Nouioui et al, 2019). Pb could be mobilized from bone back into blood, therefore blood Pb measurements reflect recent exposure and may also represent past exposures (Barbosa et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Relations of blood lead levels to echocardiographic left ventricular structure and function in preschool children

et al. 2021

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“…Results of biological monitoring of urinary metals in Tunisia are available only for Pb. The levels of Pb found in study workers were much lower than those in a small control group of 20 individuals (5.0 vs. 38 µg/L), but it should be noted that the reported values were surprisingly high [29]. The metals levels were then compared with the reference values for the Italian general population provided by the Italian Society of Reference Values (SIVR) [30], and with the DFG BAR (Table 3).…”

Section: Discussionmentioning

confidence: 99%

Biological Monitoring of Occupational Exposure to Metals in Electric Steel Foundry Workers and Its Contribution to 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine Levels

Campo

Hanchi

Sucato

et al. 2020

IJERPH

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In this study, the urinary concentrations of selected metals in workers from an electric steel foundry in Tunisia were assessed and compared with existing biological limit values and general population reference values. Moreover, the association between oxidative DNA damage, measured as urinary 8-oxo-7,8-dihydro-2’deoxyguanosine (8-oxodG) and co-exposure to metals and polycyclic aromatic hydrocarbons (PAHs) was evaluated. Urinary levels of 12 metals were determined by inductively coupled plasma-mass spectrometry (ICP-MS) in end-shift spot samples from 89 workers. The urinary levels of phenanthrene (U-PHE), as marker of exposure to PAHs, and 8-oxodG were also available. Median levels ranged from 0.4 µg/L (cobalt, Co, and thallium, Tl) to 895 µg/L (zinc, Zn). Only 1% of samples was above the biological limit values for Co, and up to 13.5% of samples were above limit values for Cd. From 3.4% (Co) to 72% (lead, Pb) of samples were above the reference values for the general population. Multiple linear regression models, showed that manganese (Mn), Zn, arsenic (As), barium (Ba), Tl, and Pb were significant predictors of 8-oxodG (0.012 ≤ p ≤ 0.048); U-PHE was also a significant predictor (0.003 ≤ p ≤ 0.059). The variance explained by models was low (0.11 ≤ R2 ≤ 0.17, p < 0.005), showing that metals and PAHs were minor contributors to 8-oxodG. Overall, the comparison with biological limit values showed that the study subjects were occupationally exposed to metals, with levels exceeding biological limit values only for Cd.

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Biomonitoring chronic lead exposure among battery manufacturing workers in Tunisia

Cited by 21 publications

References 54 publications

Effects of lead, cadmium, copper and zinc levels on the male reproductive function

Effects of lead, cadmium, copper and zinc levels on the male reproductive function

Relations of blood lead levels to echocardiographic left ventricular structure and function in preschool children

Biological Monitoring of Occupational Exposure to Metals in Electric Steel Foundry Workers and Its Contribution to 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine Levels

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