Biomphalaria glabrata cytosolic copper/zinc superoxide dismutase (SOD1) gene: Association of SOD1 alleles with resistance/susceptibility to Schistosoma mansoni

Differential expression of genes encoding anti-oxidant enzymes in Sydney rock oysters, Saccostrea glomerata (Gould) selected for disease resistance

“…A similar system has been demonstrated to be a major molecular mechanism for resistance of the freshwater snail, B. glabrata to the parasite S. mansoni is due to deficient forms of anti-oxidant enzymes in the respiratory burst pathway [35]. Resistant B. glabrata generate significantly more H 2 O 2 than susceptible snails [29] and this increased concentration of H 2 O 2 generated by resistant snails has been correlated to higher expression levels of the SOD1 transcript [36]. Expression of the SOD1 transcript was later found to be associated with one allele found in resistant snails [37].…”

Identification of differentially expressed genes in Oncomelania hupensis chronically infected with Schistosoma japonicum

“…Although the current understanding of schistosome and snail biology during the infection process is still incomplete, especially regarding the snail immunity (Bayne, 2009), a variety of molecules have been identified and may be associated with schistosome survival or snail defense mechanisms, including certain proteolytic enzymes such as cysteine proteases (Lodes and Yoshino, 1989;Guillou et al, 2007a;Humphries and Yoshino, 2008;Ittiprasert et al, 2010), receptor recognition molecules (e.g., fibrinogen-related proteins (FREPs) and lectin (Johnston and Yoshino, 2001;Hertel et al, 2005;Zhang et al, 2007;Ittiprasert et al, 2010)), molecules related to cell adhesion and signaling pathways (Goodall et al, 2006;Lockyer et al, 2007b;Zhang et al, 2007;Ittiprasert et al, 2010), and immune regulation-like epitope mimics (Plows et al, 2005;Lockyer et al, 2007b;Lehr et al, 2008). Most of the above studies aimed to decipher the differences in gene regulation between schistosome-resistant and schistosome-susceptible snails, focusing on the acute stage of schistosome-snail infection (within minutes to hours of the infection) but not chronic infection (up to >2 months) (Bayne, 2009).…”

Intracellular copper/zinc superoxide dismutase from bay scallop Argopecten irradians: Its gene structure, mRNA expression and recombinant protein

“…icCuZnSODs cDNA have been cloned from some invertebrate and vertebrate species [19][20][21][22][23][24][25][26][27][28]. However, little is known about their genomic features, immune responses against biological infections and characterization of the recombination protein.…”