Bionanoparticles of amphiphilic copolymers polyacrylate bearing cholesterol and ascorbate for drug delivery

Wang, Yanzhai; Zhuang, Dequan; Yang, Junjiao; Yang, Jing

doi:10.1016/j.jcis.2012.04.004

Cited by 32 publications

(23 citation statements)

References 57 publications

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“…A study on the use of benzyl and t-butyl trithiocarbonate and dithiobenzoate RAFT agents for VAc polymerization has 334 [385] 335 [540] 336 [429] 337 [202] 338 [242] 339 [262] 340 [317] Solketal acrylate 350 [311] 347 [344] 346 [344] 343 n ϭ 1 [234] 343 n ϭ 2 [196] 345 n ϭ 4 [362] 351 [297] 342 [196] 341 [428] 348 [311] 349 [311] 394 [396] Chart 3.…”

Section: Vinyl Monomersmentioning

confidence: 99%

Living Radical Polymerization by the RAFT Process – A Third Update

2012

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This paper provides a third update to the review of reversible deactivation radical polymerization (RDRP) achieved with thiocarbonylthio compounds (ZC(¼S)SR) by a mechanism of reversible addition-fragmentation chain transfer ( Chem. 2009Chem. , 62, 1402. This review cites over 700 publications that appeared during the period mid 2009 to early 2012 covering various aspects of RAFT polymerization which include reagent synthesis and properties, kinetics and mechanism of polymerization, novel polymer syntheses, and a diverse range of applications. This period has witnessed further significant developments, particularly in the areas of novel RAFT agents, techniques for end-group transformation, the production of micro/nanoparticles and modified surfaces, and biopolymer conjugates both for therapeutic and diagnostic applications.

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Section: Vinyl Monomersmentioning

confidence: 99%

Living Radical Polymerization by the RAFT Process – A Third Update

2012

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“…Although ATRP kinetics have not been described, AChol has been used to produce amphiphilic poly(ethylene glycol)‐ b ‐poly(cholesteryl acryloyloxy ethyl carbonate)s (PEG‐ b ‐PAChol) and then authors studied their self‐assembly properties . On the other hand, amphiphilic diblock copolymers based on other cholesteryl acrylates have also been produced using RAFT polymerization …”

Section: Introductionmentioning

confidence: 99%

Controlled synthesis of new amphiphilic glycopolymers with liquid crystal grafts

Ferji

Nouvel

Babin

et al. 2013

J. Polym. Sci. Part A: Polym. Chem.

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A cholesterol‐based liquid crystal monomer, diethylene glycol cholesteryl ether acrylate (DEGCholA), has been successfully polymerized by atom transfer radical polymerization (ATRP) for the first time. Appropriate experimental conditions to control the polymerization of DEGCholA have been investigated using a model initiator (ethyl 2‐bromoisobutyrate) in tetrahydrofuran (THF) or toluene at 60 °C. Well‐controlled ATRP of DEGCholA was obtained using N,N,N′,N′,N″‐pentamethyldiethylenetriamine as ligand in THF at 60 °C. These conditions were then applied to initiate the ATRP of DEGCholA from multifunctional macroinitiators based on dextran. Using a protection/deprotection synthetic scheme, novel graft glycopolymers (Dex‐g‐PDEGCholA) have been synthesized. The mesomorphic properties of DEGCholA, PDEGCholA, and Dex‐g‐PDEGCholA have been studied by thermal polarizing optical microscopy, differential scanning calorimetry, and X‐ray scattering. PDEGCholA and Dex‐g‐PDEGCholA show an interdigitated smectic A phase (SmAd) between Tg (∼30 °C) and around 170 °C. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 3829–3839

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“…Cholesterol is a non-toxic lipid, found naturally in humans [26]. In addition, it is widely employed as a hydrophobic anchor for polymeric nanoparticles and liposomes because of its unique properties [17,18,27]. Moreover, cholesterol has cyclic rings in its molecule, which may enhance the interaction between PTX and Chol-BSA because of their similar structure.…”

Section: Discussionmentioning

confidence: 99%

“…Cholesterol is a naturally-occurring lipid in humans, and is widely used as a hydrophobic anchor, owing to its biocompatibility [17,18].…”

Section: Introductionmentioning

confidence: 99%

Long-circulating self-assembled cholesteryl albumin nanoparticles enhance tumor accumulation of hydrophobic anticancer drug

Battogtokh

Kang

2015

European Journal of Pharmaceutics and Biopharmaceutics

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Bionanoparticles of amphiphilic copolymers polyacrylate bearing cholesterol and ascorbate for drug delivery

Cited by 32 publications

References 57 publications

Living Radical Polymerization by the RAFT Process – A Third Update

Living Radical Polymerization by the RAFT Process – A Third Update

Controlled synthesis of new amphiphilic glycopolymers with liquid crystal grafts

Long-circulating self-assembled cholesteryl albumin nanoparticles enhance tumor accumulation of hydrophobic anticancer drug

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