Bionic design and verification of 3D printed PEEK costal cartilage prosthesis

Zhang, Chenguang; Wang, Ling; Kang, Jianfeng; Fuentes, Óscar Martel; Li, Dichen

doi:10.1016/j.jmbbm.2019.103561

Cited by 35 publications

(17 citation statements)

References 19 publications

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“…They also observed mechanical outcome difference between the four different types of FFF materials. Moreover, Zhang et al 38 3D printed a PEEK costal cartilage prothesis with PEEK which provided comparable tensile strength (0.7–8.3 MPa) to the natural costal cartilage (4–7 MPa). Likewise, Wang et al 3 3D printed PEEK rib prosthesis for chest reconstruction and reported that 3D printed implant's tensile strength was 91% of the traditionally manufactured material.…”

Section: Resultsmentioning

confidence: 99%

“…Of these studies, two printed cuboids, 36,39 one used disk samples and indicated the possibility for dental applications, 40 and one printed dental inlays 35 . There are four studies which explored FFF PAEKs for chest wall reconstruction, which included anterior chest wall construction, 3 costal cartilage, 38 rib, 2 and scapula prosthesis 43 …”

Section: Resultsmentioning

confidence: 99%

“…AM dental inlays showed between 48 and 103% strength of machined inlays. AM costal cartilage prosthesis is shown to be in the range of natural costal cartilage 38 . Only a few studies (18%) printed and tested standard dog‐bone specimens in addition to printed implants/scaffolds to determine the mechanical properties of 3D printed materials.…”

Section: Discussionmentioning

confidence: 99%

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Structure, properties, and bioactivity of 3D printed PAEKs for implant applications: A systematic review

et al. 2021

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Additive manufacturing (AM) of high temperature polymers, specifically polyaryletherketones (PAEK), is gaining significant attention for medical implant applications. As 3D printing systems evolve toward point of care manufacturing, research on this topic continues to expand. Specific regulatory guidance is being developed for the safe management of 3D printing systems in a hospital environment. PAEK implants can benefit from many advantages of AM such as design freedom, material and antibacterial drug incorporation, and enhanced bioactivity provided by cancellous bone‐like porous designs. In addition to AM PAEK bioactivity, the biomechanical strength of 3D printed implants is crucial to their performance and thus widely studied. In this review, we discuss the printing conditions that have been investigated so far for additively manufactured PAEK implant applications. The effect of processing parameters on the biomechanical strength of implants is summarized, and the bioactivity of PAEKs, along with material and drug incorporation, is also covered in detail. Finally, the therapeutic areas in which 3D printed PAEK implants are investigated and utilized are reviewed.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Structure, properties, and bioactivity of 3D printed PAEKs for implant applications: A systematic review

et al. 2021

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“…Fused deposition modeling (FDM) is a 3-dimensional printing method for PEEK implants. Compared to traditional injection molding, it offers certain advantages such as simplified processes, improved timeliness, lower costs, and the ability to create a customized prosthesis to match the bone defect site [ 10 , 11 ]. Current studies have suggested that pore sizes larger than 100 μm can provide sufficient space for vascularization, nutrients supply, waste removal, and oxygen diffusion [ 12 ], and the recommended interconnected macropore structures of 300–500 μm are better for adequate capillary and bone ingrowth [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Magnesium surface-activated 3D printed porous PEEK scaffolds for in vivo osseointegration by promoting angiogenesis and osteogenesis

Wei

Zhou

Tang

et al. 2023

Bioactive Materials

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“…[12,13] Combining with 3D printing (3DP) technology, skeletal and individual PEEK implants were made to repair the chest wall defect in our previous studies. [5,[14][15][16] Up to now, more than 100 3DP PEEK implants have been used in our hospital. Unfortunately, some side effects of PEEK implants have been gradually realized in several years after clinical practices.…”

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confidence: 99%

Facile Amidogen Bio‐Activation Method Can Boost the Soft Tissue Integration on 3D Printed Poly–Ether–Ether–Ketone Interface

Liu

Huang

Zhang

et al. 2021

Adv Materials Inter

Self Cite

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materials, bio-medicals, mechanics, and chemistry. Recently, the most commercialized artificial bone, titanium alloy based artificial bone, has been widely used in spine surgery, dental surgery, and thoracic surgery. [2][3][4] However, artificial bone with better biocompatibility, mechanical strength, and superior radiography properties is still desired. [5] Polyether-ether-ketone (PEEK) based artificial bone attracted tremendous interests due to its similar elastic modulus compared to that of cortical bone, [6][7][8] compatibility to radioluscent and magnetic resonance imaging [5,9] and chemical stability. [9][10][11] Therefore, PEEK has been extensively investigated and successfully used in spinal fusion, trauma, neurosurgical and craniomaxillofacial procedures, dental operation, joint replacements, and anterior cruciate ligaments repair. [12,13] Combining with 3D printing (3DP) technology, skeletal and individual PEEK implants were made to repair the chest wall defect in our previous studies. [5,[14][15][16] Up to now, more than 100 3DP PEEK implants have been used in our hospital. Unfortunately, some side effects of PEEK implants have been gradually realized in several years after clinical practices. The most happened cases are unsatisfactory cellular response and poor integration among the implants and Poly-ether-ether-ketone (PEEK) implants with good mechanical properties and chemical inertia, meet the urgent needs of bone substitute. However, its inert interface leads to poor soft tissue integration, which prolongs healing time of surgical incision with many complications. Herein, (3-aminopropyl) triethoxysilane is connected to 3D printed (3DP) PEEK interface by chemical modification. The homogeneous amino groups on amidogen interface enhance PEEK's hydrophilicity and proteinophilia significantly. Fibroblasts cultured on the amidogen PEEK interface show much stronger potential of cell adhesion and migration. Furthermore, soft tissue ingrowth into 3DP PEEK scaffold occurs more and faster in the amidogen interface in vivo. The observation of the microstructure shows tighter implant-tissue bonding interfaces on the amidogen PEEK. To mimic real surgery, 3DP PEEK implants of the same proportions in clinical practice are used to reconstruct the chest wall defects of rabbits. A significant reduction in healing time and incision complications are observed in the amidogen PEEK groups. In addition, 19 related proteins are found in the fibroblasts cultured on the amidogen PEEK interface, which can be used to trace the biological mechanisms. In all, the facile amidogen bio-activation method can significantly boost the soft tissue integration on 3DP PEEK interface with less surgical complications.

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Bionic design and verification of 3D printed PEEK costal cartilage prosthesis

Cited by 35 publications

References 19 publications

Structure, properties, and bioactivity of 3D printed PAEKs for implant applications: A systematic review

Structure, properties, and bioactivity of 3D printed PAEKs for implant applications: A systematic review

Magnesium surface-activated 3D printed porous PEEK scaffolds for in vivo osseointegration by promoting angiogenesis and osteogenesis

Facile Amidogen Bio‐Activation Method Can Boost the Soft Tissue Integration on 3D Printed Poly–Ether–Ether–Ketone Interface

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