Bioorganometallic chemistry of molybdocene dichloride

Waern, Jenny B.; Harding, Margaret M.

doi:10.1016/j.jorganchem.2004.08.014

Cited by 67 publications

(54 citation statements)

References 86 publications

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“…Current evidence is consistent with formation of a Ti(IV) species that lacks the Cp ligands which interacts with DNA, possibly transported into the cell via the iron transporter protein transferrin [4]. Compared with Cp 2 TiCl 2 , Cp 2 MoCl 2 is an attractive candidate for drug development as the complex is water-soluble and stable to hydrolysis of the Cp ligands at physiological pH [5,6]. On the other hand, Cp 2 MoCl 2 suffers rapid and extensive hydrolysis of the chloride ligands [5,6a].…”

Section: Introductionmentioning

confidence: 91%

Inclusion of molybdenocene dichloride (Cp2MoCl2) in 2-hydroxypropyl- and trimethyl-β-cyclodextrin: Structural and biological properties

Braga

Marques

Sousa

et al. 2005

Journal of Organometallic Chemistry

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Organometallic-cyclodextrin inclusion compounds were obtained by the treatment of molybdenocene dichloride (Cp 2 MoCl 2 ) with the modified cyclodextrins (CDs) heptakis-2,3,6-tri-O-methyl-b-CD (TRIMEB) and 2-hydroxypropyl-b-CD (HPbCD) in aqueous solution. The products were isolated by liophilisation and characterised in the solid-state by powder XRD, thermogravimetric analysis, Raman and FTIR spectroscopy, and 13 C CP MAS NMR spectroscopy. The results are consistent with inclusion of Cp 2 MoCl 2 , rather than hydrolysis products such as [Cp 2 Mo(H 2 O)X] + (X = Cl, OH) or [Cp 2 Mo(H 2 O) 2 ] 2+ . The pure non-included metallocene Cp 2 MoCl 2 and its inclusion compounds with unmodified b-CD, TRIMEB and HPbCD were screened for their potential antiproliferative and cytotoxic activity, in both human cancer and healthy cell lines. Inclusion in CD was found to enhance the cytotoxic effect of Cp 2 MoCl 2 , with the TRIMEB adduct displaying the highest anti-tumour activity, along with the lowest toxicity towards non-neoplastic cells.

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Section: Introductionmentioning

confidence: 91%

Inclusion of molybdenocene dichloride (Cp2MoCl2) in 2-hydroxypropyl- and trimethyl-β-cyclodextrin: Structural and biological properties

Braga

Marques

Sousa

et al. 2005

Journal of Organometallic Chemistry

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“…Biochem., 10 (6): 267-280, 2015 (Curzon andCutress, 1983), malabsorption states (Underwood, 1977) and certain type of cancers (Waern and Harding, 2004;Brewer, 2005). Molybdenum has also been recommended as antidiabetic agent.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Molybdenum Induced Alteration in Oxidative Indices, Biochemical Parameters and Sperm Quality in Testis of Wistar Male Rats

Pandey¹,

Jain²

2015

Asian J. of Biochemistry

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The present study was carried out to investigate the effects of ammonium molybdate on lipid peroxidation, antioxidant, biochemical and semen parameters in male Wistar rats. Group I served as control while group II, III and IV received 50, 100 and 150 mg kgG for 60 days and thereafter left for recovery study for 60 days. The present study examined the effects of ammonium molybdate on serum testosterone, Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) along with sperm parameters. Estimations were also made for marker biochemical and antioxidant parameters in testis. Ammonium molybdate treatment resulted in a dose dependent reduction in serum testosterone, FSH, LH, sperm count, motility and viability. The concentration of total protein and sialic acid as well as activities of acid phosphatase (ACP) and alkaline phosphatase (ALP) were decreased in a dose dependent manner while there was a significant increase in the glycogen and cholesterol level in testis. The level of Thiobarbituric Acid Reactive substance (TBARs) was increased while the activities of superoxide dismutase and concentration of glutathione and ascorboic acid was decreased significantly in testis of rats treated with ammonium molybdate. All the parameters showed significant improvement after 60 days of treatment withdrawal in highest dose group. The findings suggested that ammonium molybdate exerts a deleterious effect on testicular function by altering biochemical and antioxidant status of the testes.

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“…The possibility of using organometallics in this context was first raised by Gill and Mann [93]. These authors were interested in the possibility of labeling a ferrocene with 59 Fe, a radioactive isotope of iron, which is a mixed β and γ emitter with a half-life of 44.5 days. Injection of a synthetic polypeptide labeled with 2 or 16 ferrocene entities into rabbits produced anti-ferrocene specific antibodies, incidentally establishing the non-toxicity and stability of ferrocene in vivo.…”

Section: Bioanalytical Methods Based On Special Properties Of Organommentioning

confidence: 99%

“…Phase I clinical trials indicate that it is well tolerated in human subjects [55]. In parallel with the studies being carried out in coordination chemistry, organometallic complexes of the same type have also been the subject of considerable endeavor, particularly those in the metallocene series with metals such as Ti, Fe, Mo, V, Re, Co, Ru, [56][57][58][59]. Titanocene dichloride, 13, is paradigmatic; the structural analogy between 13 and cisplatin 8 is immediately clear.…”

Section: 25mentioning

confidence: 99%

A Novel Field of Research: Bioorganometallic Chemistry, Origins, and Founding Principles

2005

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Bioorganometallic chemistry of molybdocene dichloride

Cited by 67 publications

References 86 publications

Inclusion of molybdenocene dichloride (Cp2MoCl2) in 2-hydroxypropyl- and trimethyl-β-cyclodextrin: Structural and biological properties

Inclusion of molybdenocene dichloride (Cp2MoCl2) in 2-hydroxypropyl- and trimethyl-β-cyclodextrin: Structural and biological properties

Assessment of Molybdenum Induced Alteration in Oxidative Indices, Biochemical Parameters and Sperm Quality in Testis of Wistar Male Rats

A Novel Field of Research: Bioorganometallic Chemistry, Origins, and Founding Principles

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