Biopartitioning micellar chromatography: An alternative high-throughput method for assessing the ecotoxicity of anilines and phenols

Bermúdez-Saldaña, José María; Escuder-Gilabert, Laura; Medina-Hernández, M.J.; Villanueva-Camañas, R.M.; Sagrado, S.

doi:10.1016/j.jchromb.2007.01.041

Cited by 13 publications

(3 citation statements)

References 23 publications

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“…Owing to the large number of chemical substances in everyday use, high costs and long time of investigations of their toxicity as well as ethical aspects connected with experiments on animals, it is necessary to apply fast and inexpensive methods of determination of toxic substances and develop alternative methods to in vivo ones for the preliminary determination of potential toxic properties of studied substances. One of these methods is MLC, particularly BMC, which combined with the in silico methods can be used for preliminary screening of compound toxicity (Bermudez‐Saldana et al ., ). There are many papers presenting the applicability of the MLC method in in vitro studies on toxicity of various groups of compounds (Table ).…”

Section: Analysis Of Biologically Active Compounds In Body Fluidsmentioning

confidence: 99%

A concise review of applications of micellar liquid chromatography to study biologically active compounds

Stępnik¹

2016

Biomedical Chromatography

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The features of micellar systems are outstanding compared with conventional RP-LC ones. Therefore, the unique properties of micellar chromatography (MLC) are widely recognized. In this short review the applicability of MLC as an in vitro method for the determination of biological activity is discussed. For this purpose many specific examples of MLC applications supported by the theoretical backgrounds of the cited biological activity areas as well as the factors affecting them are presented. This study collects and organizes the most important references of bioactivity determination which were created both recently and in the past, using the MLC method. Although there are many papers on the MLC there is no literature review focused particularly on its applicability in the study of biological activity of various compounds. This work can be treated as a significant review of so far published papers which particularly emphasizes the importance of MLC as in vitro method for determination of bioactivity of different compounds. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Analysis Of Biologically Active Compounds In Body Fluidsmentioning

confidence: 99%

A concise review of applications of micellar liquid chromatography to study biologically active compounds

Stępnik¹

2016

Biomedical Chromatography

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“…Medina-Hernandez research group had extended the QRAR model based on BMC to investigate activity and toxicity for various types of drugs, such as antihistamine drugs, benzodiazepines, pesticides, butyrophenones, antipsychotics, antidepressant drugs, aromatic amines, anilines and phenols and so [89][90][91][92][93][94][95][96][97][98][99][100]. Recently, other research groups also adopted this method to carry out pharmacokinetic/pharmacodynamic study for quinolones, cardiovascular system drugs and antihypertensive drugs, etc [101][102][103][104].…”

Section: Biopartitioning Micellar Chromatography (Bmc)mentioning

confidence: 99%

Profiling Drug Membrane Permeability and Activity Via Biopartitioning Chromatography

Sun¹,

Wu²,

Lu³

et al. 2008

CDM

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Drug in vivo pharmacokinetic performances in nature consist of sequential membrane transporting processes and are based on the entry into and exit of drugs from cell, even for metabolism process requiring parent drugs delivered into and metabolites effluxed from the metabolizing cells. Efficient and reliable high throughput screen of membrane permeability properties as early as possible in drug discovery and development program is accordingly desirable. Biopartitioning chromatography (BPC) introduces biomembrane-mimetic structures (such as liposome, phospholipid monolayer, micelle, microemulsion, vesicle and bicelle, etc) into chromatographic system, i.e. liquid system or capillary electrophoresis, and thereby emulates drug-membrane interactions difficult to study in the liquid state by well reproducible, rapid, sensitive and adequately designed chromatographic technique. And recently BPC has been becoming a high-throughput screening platform for drug membrane permeability and biological activity. The theoretical basis, classification and application of BPC were summarized based on the latest advances and our recent works. The development potential and perspectives of this field were also discussed.

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“…RPLC with stationary phases, which imitate biosystems such as immobilized artificial membranes (IAMs) or immobilized liposomes , are used to describe gastrointestinal and dermal drug absorption. Other chromatographic approaches used to model the absorption of drugs administered orally are micellar liquid chromatography (MLC) and biopartitioning micellar chromatography (BMC) .…”

Section: Introductionmentioning

confidence: 99%

Retention-property relationships of 1,2,4-triazoles by micellar and reversed-phase liquid chromatography

Janicka

Pachuta‐Stec

2014

J. Sep. Science

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The properties of 21 1,2,4-triazoles, relevant to their pharmacokinetics, were investigated using experimental methods and in silico calculations. The lipophilicities of the compounds were determined experimentally using reversed-phase chromatography and liquid chromatography with micellar mobile phases, or they were calculated in silico from their molecular structures. In the reversed-phase technique, an octadecylsilyl, immobilized artificial membrane and immobilized cholesterol were used as the stationary phases. Biological descriptors of compounds, i.e. log BB, log KHSA, Caco-2, and fu,brain, were determined in silico by using ACD/Percepta software. Principal component analysis was used to indicate similarities between chromatographic, partitioning, and biological variables. Highly significant relationships were determined to exist between the chromatographic parameters and the biological descriptors, especially for log BB and log KHSA. The chromatographic parameters measured on the cholesterol column were recommended for use in predicting the lipophilic and biological properties of the 1,2,4-triazoles that were tested.

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Biopartitioning micellar chromatography: An alternative high-throughput method for assessing the ecotoxicity of anilines and phenols

Cited by 13 publications

References 23 publications

A concise review of applications of micellar liquid chromatography to study biologically active compounds

A concise review of applications of micellar liquid chromatography to study biologically active compounds

Profiling Drug Membrane Permeability and Activity Via Biopartitioning Chromatography

Retention-property relationships of 1,2,4-triazoles by micellar and reversed-phase liquid chromatography

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