2020
DOI: 10.3390/pharmaceutics12060550
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Bioprinting and Preliminary Testing of Highly Reproducible Novel Bioink for Potential Skin Regeneration

Abstract: Three-dimensional (3D) bioprinting is considered as a novel approach in biofabricating cell-laden constructs that could potentially be used to promote skin regeneration following injury. In this study, a novel crosslinked chitosan (CH)–genipin (GE) bioink laden with keratinocyte and human dermal fibroblast cells was developed and printed successfully using an extruder-based bioprinter. By altering the composition and degree of CH–GE crosslinking, bioink printability was further assessed and compared with a com… Show more

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Cited by 57 publications
(34 citation statements)
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References 63 publications
(86 reference statements)
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“…Bioinks are known as biological materials fluids loaded into the 3D-bioprinter system to construct scaffolds with a specific design using a layer-by-layer printing technique [ 20 ]. The main components involved to create the bioinks are biomaterials, cells, and suitable crosslinkers.…”
Section: 3d-bioprinting For Wound Healing and Skin Regenerationmentioning
confidence: 99%
See 1 more Smart Citation
“…Bioinks are known as biological materials fluids loaded into the 3D-bioprinter system to construct scaffolds with a specific design using a layer-by-layer printing technique [ 20 ]. The main components involved to create the bioinks are biomaterials, cells, and suitable crosslinkers.…”
Section: 3d-bioprinting For Wound Healing and Skin Regenerationmentioning
confidence: 99%
“…Human dermal fibroblasts (HDFs) are differentiated from highly proliferative progenitor fibroblasts and responsible for maintaining skin tissues’ structural support [ 20 ]. During the formation of the dermal and wound repair process, HDFs are essential in response to stimuli and ECM proteins’ formation [ 21 ].…”
Section: Introductionmentioning
confidence: 99%
“…Admane et al proved that 3D bioprinted skin fabricated using a mixture of silk and gelatin was dimensionally stable relative to the collagen-based skin structure [ 179 ]. More recently, Hafezi et al designed an alginate and chitosan–genipin–PEG-based three-layer skin tissue [ 180 ]. They also optimized the crosslinking ratio of chitosan and genipin to alter printability, comparable to that of commercial bio-ink.…”
Section: Current Applications Of Tissue Engineering Based On 3d Bimentioning
confidence: 99%
“…The 3D construct is assembled in an additive manner by printing layer by layer [ 34 ] (arrow). Figure reproduced and adapted from Hafezi et al (2020) [ 36 ]. Copyright MDPI, 2020.…”
Section: Figurementioning
confidence: 99%