Bioresorbable devices made of forged composites of hydroxyapatite (HA) particles and poly-?-lactide (PLLA): Part I. Basic characteristics

Shikinami, Yasuo

doi:10.1016/s0142-9612(98)00241-5

Cited by 625 publications

(493 citation statements)

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“…A biocompatible and biodegradable osteosynthesis membrane (Super-Fixsorb-MX, Takiron, Osaka, Japan), made from composites of uncalcined and unsintered hydroxyapatite (uHA) particles and PLLA, was developed in previous studies and has been clinically applied 25,26) . This material exhibits a mesh-like structure, an elasticity close to that of the natural cortical bone, and high strength during the period required for bone healing, making it superior to unfilled PLLA 24) .…”

Section: Introductionmentioning

confidence: 99%

Guided bone regeneration using a hydrophilic membrane made of unsintered hydroxyapatite and poly(L-lactic acid) in a rat bone-defect model

et al. 2018

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The effectiveness of a previously developed unsintered hydroxyapatite (uHA) and poly(L-lactic acid) (PLLA) hydrophilic membrane as a resorbable barrier for guided bone regeneration (GBR) was evaluated. Critical-size 8-mm diameter bone defects were surgically generated in the parietal bones of 24 12-week-old male Wistar rats, which were then divided into three groups in which either a uHA/ PLLA or a collagen membrane or no membrane (control) was placed onto the bone defect. Following sacrifice of the animals 2 or 4 weeks after surgery, bone defects were examined using microcomputed tomography and histological analysis. Bone mineral density, bone mineral content, and relative bone growth area values 2 or 4 weeks after surgery were highest in the uHA/PLLA group. Four weeks after surgery, the relative bone growth area in the uHA/PLLA group was larger than that in the collagen group. The resorbable uHA/PLLA membrane is thus potentially effective for GBR.

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Section: Introductionmentioning

confidence: 99%

Guided bone regeneration using a hydrophilic membrane made of unsintered hydroxyapatite and poly(L-lactic acid) in a rat bone-defect model

et al. 2018

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“…With increase in hydrolytic degradation, PLLA tends to show a decrease in average molecular weight, a slow rise in melting point, and an increase in degree of crystallization 7,8,13,15 . In this study, a decrease in average molecular weight and an increase in degree of crystallization also occurred over time, indicating on increase in hydrolytic degradation and embrittlement.…”

Section: Discussionmentioning

confidence: 99%

“…The devices are produced by a forging process involving a unique method of compression molding and machining 13 . The plates were short and straight (22 mm long, 4.5 mm wide, and 1.5 mm thick) and had 4 holes.…”

Section: Specimensmentioning

confidence: 99%

“…Some have evaluated the stability of bone segments after employment of PLLA in oral and maxillofacial surgery 1,17,18 . Others have evaluated the dynamic and chemical properties of these materials 2,8,13 , or changes in their physical properties with hydrolytic degradation 7,8,13,15 .…”

Section: Introductionmentioning

confidence: 99%

“…Some found that PLLA retains about 80% of its original bending strength for 12 weeks after hydrolytic degradation sets in, quickly decreasing in strength thereafter 7,8,13,15 .…”

Section: Introductionmentioning

confidence: 99%

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Changes in mechanical properties of poly-l-lactic acid mini-plate under functional load simulating sagittal splitting ramus osteotomy

Mizuhashi

Suga

Uchiyama

et al. 2008

International Journal of Oral and Maxillofacial Surgery

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The purpose of this study was to investigate how the characteristics of a poly-L-lactic acid mini-plate changed with dynamic loading in an environment with hydrolytic degradation.We prepared a mandible osteosynthesis model with specimen poly-L-lactic acid mini-plates to simulate sagittal splitting ramus osteotomy. The model was then subjected to dynamic loading, and changes in specimen shape and surface quality were observed. Specimen bending strength was then measured, and degree of hydrolytic degradation estimated. Statistical studies included an analysis of variance (ANOVA).Neither dynamic loading nor degree of load clearly affected degree of hydrolytic degradation. The specimens maintained their original shape and bending strength for up to 4 weeks with dynamic loading of 40 N or less in an environment with hydrolytic degradation. However, at 8 weeks, under the same conditions, the specimens showed cracks or fractures, or both, together with a clear decrease in bending strength.The results suggest that dynamic loading causes cracking in a poly-L-lactic acid mini-plate, and that growth of those cracks decreases bending strength over time, leading to fatigue fracture.--2

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Initial Management of Total Nasal Septectomy Defects Using Resorbable Plating

Santina

Byrne²

2006

Archives of Facial Plastic Surgery

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Bioresorbable devices made of forged composites of hydroxyapatite (HA) particles and poly-?-lactide (PLLA): Part I. Basic characteristics

Cited by 625 publications

References 0 publications

Guided bone regeneration using a hydrophilic membrane made of unsintered hydroxyapatite and poly(L-lactic acid) in a rat bone-defect model

Guided bone regeneration using a hydrophilic membrane made of unsintered hydroxyapatite and poly(L-lactic acid) in a rat bone-defect model

Changes in mechanical properties of poly-l-lactic acid mini-plate under functional load simulating sagittal splitting ramus osteotomy

Initial Management of Total Nasal Septectomy Defects Using Resorbable Plating

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