Biosensor concept and data input to biomedical infornation systems

Abstract

Background. In present publication we generalized and analyzed deeply the experience of some biosensors studying in biophysical experiments with aim to incorporate them further to electronic information systems. Output biosensor electrical signals were input ones to electronic information system making their connection into joined bioinformation system. Materials and methods. Methods of comparative analysis of the characteristics of input and output electrical information signals of biosensor were applied; its physical and mathematical models were developed. For biosensor properties studies the methods of transmembrane electric currents recording in voltage-clamp mode as well as patch-clamp on hippocampal neuronal membranes were used. Results. Biosensor concept and their general characteristic were given, corresponding prototypes were observed. The physical model of biosensor was developed and some test results of this device were suggested. The biosensor was examined as abstraction in consistent unity of its functions: signal receiver — filter — analyzer — encoder/decoder. A brief mathematical description of biosensor functioning was given as well as corresponding algorithm. As a result of performed works the possibilities of this biosensor incorporation to bioinformation electronic systems were substantiated and the example of such system «EcoIS» was observed. Conclusion. In conclusion following results of the works were summarized. The detailed description of technical devices — biosensors as elements of biomedical information systems were done as well as analysis of electrical information signals at output of biosensor, its ability to encode information and detailed analysis of the possibility to incorporate this biotechnical device into electronic information systems due to biosensor output electricals signals.

Information Technologies: Physical and Mathematical Models of Detectors for Environment Monitoring Systems

“…Developing the information system with incorporated elements for chemo-sensitivity is necessary, in the first order, to solve the problem of sensitive detectors of high quality as well as problem of the data input in general. Some prototypes of such ISs had been already presented in some our works as well as the works of other authors [1] - [4], [6] - [11], [16]. One of such automated information system (AIS) had been described in [1] - [4].…”

“…The first one group included detectors developed on idea of biosensor [10] - [13], with "biosensor-like" functions, which were sensitive to chemicals like biological objects (cells, their membranes, etc.) [10], [11], [13]. The authors have already developed some versions of ISs with such "biosensor-like" detectors [10], [11].…”

“…[10], [11], [13]. The authors have already developed some versions of ISs with such "biosensor-like" detectors [10], [11]. Other, the second group of detectors included detectors with surfaces, covered with thin layers, films or membrane with ion-selective properties.…”

“…[1] - [4], [6] - [9]. Such detecting devices with functions of sensitivity for different chemical substances in environment can be used as elements of large-scaling information system [10], [11].…”

“…[10], [16]. Such elements being in contact with some acted chemicals have to reveal chemo-sensitivity and; in some cases, even ability for primary processing of information, doing initial identification of these substances [10], [11].…”