Biosensors for the enantioselective analysis of pipecolic acid

Stefan, Raluca‐Ioana; Nejem, R’afat Mahmoud; Staden, Jacobus Frederick van; Aboul‐Enein, Hassan Y.

doi:10.1016/s0925-4005(03)00366-6

Cited by 19 publications

(9 citation statements)

References 21 publications

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“…The values of amperometric selectivity coefficients for all the biosensors designed for L and D pipecolic acid were higher than 2. Proposed biosensors were used in clinical analysis to detect L or D-pipecolic acid in serum samples (Stefan et al 2003c). …”

Section: Chiral Catalysismentioning

confidence: 99%

Chiral Biosensors and Immunosensors

Trojanowicz¹,

Kaniewska²

2011

Biosensors - Emerging Materials and Applications

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Section: Chiral Catalysismentioning

confidence: 99%

Chiral Biosensors and Immunosensors

Trojanowicz¹,

Kaniewska²

2011

Biosensors - Emerging Materials and Applications

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“…That type of biosensor was used for example to enantioselective detection of (S)-captopril [32]. l-amino acid oxidase combined with horseradish peroxidase can be employed for detection of pipecolic acid [33]. The same enzymes combined also with glucose oxidase were used to detection of dand l-methotrexate [34].…”

Section: Enzymatic Biosensorsmentioning

confidence: 99%

Electrochemical Chiral Sensors and Biosensors

Trojanowicz

Kaniewska

2009

Electroanalysis

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Chiral molecular recognition depends on difference in stability constants of diastereomeric complexes with applied selectors, different migration of enantiomers based on the formation and dissociation of diastereomeric complexes, and on a different interaction rate of enantiomers with selector. Selected examples of electrochemical enantioselective sensors and biosensors based on different mechanisms of molecular recognition are reviewed. Chemical chiral sensors can be based on plasticized membranes incorporating a chiral ionophore, on differences of Gibbs free energy for interphase electron transfer, or on the use of molecularly imprinted polymers and electrodeposited conducting polymers doped with chiral ions. Reported chiral biosensors include enzymatic devices and immunosensors. Especially pronounced enantioselectivity of enzymatic biosensors can be employed practically, e.g., in food control, showing chiral discrimination better that two orders of magnitude. Developed, so far, chemical sensors show enantioselectivity usually not exceeding two orders magnitude and require further investigation for any practical analytical applications.

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“…With amino acid oxidases also multienzyme biosensors were developed for determination of various drugs. Similar methods of enzyme immobilization have been used for detection of pipecolic acid with the use of amino acid oxidases and peroxidase (Stefan et al 2003c). The best enantioselectivity was obtained for three enzyme system with L-AAOx (selectivity coefficient pK amp ¼ 3.09) (Stefan et al 2003b).…”

Section: Enantioselective Sensors and Biosensorsmentioning

confidence: 99%

Electrochemical and Piezoelectric Enantioselective Sensors and Biosensors

Trojanowicz

Wcisło

2005

Analytical Letters

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Enantioselectivity in chemical and biochemical sensing probes can be obtained by the use of enantioselective binding or by enantioselective biocatalysis. The enantioseletive discrimination in ion-selective electrodes can be achieved with the use of appropriate ionophore in plasticized membrane in measuring cell or on the surface of electrode, with the use of a suitable enzyme in biosensor, antibody in immunosensor, or molecularly imprinted polymer for modification of active surface of amperometric or voltammetric sensor. This review, based on 77 literature references mostly from 1992 to 2004, reports developments of such sensors for potentiometric, amperometric, and mass-detecting devices involving quartz crystal microbalances. for allowing MW to have study visits in their laboratories to get experimental experience in fabrication of potentiometric sensors and amperometric biosensors.

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Biosensors for the enantioselective analysis of pipecolic acid

Cited by 19 publications

References 21 publications

Chiral Biosensors and Immunosensors

Chiral Biosensors and Immunosensors

Electrochemical Chiral Sensors and Biosensors

Electrochemical and Piezoelectric Enantioselective Sensors and Biosensors

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