Biospecimen Use Correlates with Emerging Techniques in Cancer Research: Impact on Planning Future Biobanks

Cole, Alexandra; Cheah, Stefanie; Dee, Simon; Hughes, Shevaun; Watson, Peter H.

doi:10.1089/bio.2012.0038

Cited by 24 publications

(21 citation statements)

References 11 publications

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“…Text mining of cancer research publications verifies the increased use of human tissue samples in cancer research over the last two decades. 94,95 However, these studies may not demonstrate the value in biobanking per se but rather demonstrate an investigator's ability to use tissues in research. Techniques that rapidly and routinely extract genomic and proteomic derivatives from the ever decreasing amounts of tissue have allowed researchers a means to use tissue more effectively in order to answer their questions.…”

Section: Has Translational Research Been Better Off With Biobanks?mentioning

confidence: 99%

Getting the message about biobanking: returning to the basics

Catchpoole¹

2017

BSAM

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Much has been written about biobanks and biobanking. Since biobanking rose to prominence in the 1990s and became a scientific discipline in its own right, the collection and distribution of human tissue samples or "biospecimens" has been the subject of much critique, debate, and assessment. However, what is the message these discussions provide the wider research community? Are they reflective of progression of a new discipline? Do they represent clarity in the field or confusion? At one point we are told that biobanks are vital infrastructure, yet in the next breath we are told that biobanks are complex, full of risk, inefficient, and unsustainable. Biobanks struggle to receive sustainable funding with many restructuring or closing down, producing dilemmas about what to do with the legacy resources. This review critiques five key messages being relayed by the biobanking community, identifying the five messages that are actually being received by the research community. It also presents a "back to basics" view for biobanking that will return our attention back to five fundamental principles that should guide the ongoing discussion. This includes that biobanking is about the active provision of tissue for research that is vital for improved health outcomes. This activity is founded in human interrelationships, is already performed routinely within hospitals, and is driven by the opportunity to learn from the information contained within the biospecimens. The examples provided will be drawn from New South Wales, Australia, where building a state-wide biobanking infrastructure has been implemented, and which highlight areas where back to basics approach will be beneficial. A back to basics view of biobanking will highlight that the current positions proposed to deal with these issues are mere "straw men" solutions and that the need for a fundamental shift in our thinking is the real issue that needs to be addressed.

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Section: Has Translational Research Been Better Off With Biobanks?mentioning

confidence: 99%

Getting the message about biobanking: returning to the basics

Catchpoole¹

2017

BSAM

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“…The BRC was developed in partnership by the University Of British Columbia Office of Biobank Education and Research (OBER) and CTRNet to provide services and tools that support researchers in establishing and operating biobanks, to educate and promote certification of biobanks in order to enhance quality through adoption of best practice standards, and to publish biobank market research data. 25,26 This kind of data is essential to successfully execute a biobanking business plan to facilitate shifting to customer focused biobanking. The BRC is an example of a resource that offers strategies and solutions in all sustainability dimensions.…”

Section: General Strategies To Address Biobank Sustainabilitymentioning

confidence: 99%

“…In this work we assessed the trends in biospecimen numbers, preservation formats, and technical applications for use, across more than two decades. 25,26 Similarly, the BRC offers access to an online Biobank User Fee Calculator, to facilitate assessment of user fees. 24 This calculator includes a range of default values and a setting based on the CTRNet experience and opinion, but also allows user specific values to be entered for almost all variables.…”

Section: Financial Dimensionmentioning

confidence: 99%

A Framework for Biobank Sustainability

Watson

Nussbeck

Carter

et al. 2014

Biopreservation and Biobanking

Self Cite

113

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Each year funding agencies and academic institutions spend millions of dollars and euros on biobanking. All funding providers assume that after initial investments biobanks should be able to operate sustainably. However the topic of sustainability is challenging for the discipline of biobanking for several major reasons: the diversity in the biobanking landscape, the different purposes of biobanks, the fact that biobanks are dissimilar to other research infrastructures and the absence of universally understood or applicable value metrics for funders and other stakeholders. In this article our aim is to delineate a framework to allow more effective discussion and action around approaches for improving biobank sustainability. The term sustainability is often used to mean fiscally self-sustaining, but this restricted definition is not sufficient for biobanking. Instead we propose that biobank sustainability should be considered within a framework of three dimensions - financial, operational, and social. In each dimension, areas of focus or elements are identified that may allow different types of biobanks to distinguish and evaluate the relevance, likelihood, and impact of each element, as well as the risks to the biobank of failure to address them. Examples of practical solutions, tools and strategies to address biobank sustainability are also discussed.

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“…To overcome this challenge, market data were collected from publications, including analyses of cancer researchers' publications using biospecimens over the past 20 years. 5,[25][26][27][28] In addition, researchers at SJHMC/BNI were surveyed to identify their biospecimen and related service needs. These data informed the decision to expand the SJHMC/BNI Biobank based upon specific recommendations of what internal and external researchers wanted and needed.…”

Section: The Biobank Core Facilitymentioning

confidence: 99%

Sustainability in a Hospital-Based Biobank and University-Based DNA Biorepository: Strategic Roadmaps

Seiler

Eschbacher

Bowser

et al. 2015

Biopreservation and Biobanking

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Sustainability in the biobanking community has recently become an important and oft-discussed issue as biorepositories struggle to balance limited external funding and complex cost recovery models with high operating costs and the desire to provide the highest quality materials and services to the research community. A multi-faceted view of biobanking sustainability requires consideration of operational and social sustainability in addition to the historical focus exclusively on financial sustainability. Planning and implementing this three pillar model creates a well-rounded biorepository that meets the needs of all the major stakeholders: the funders, the patients/depositors, and the researcher recipients. Often the creation of a detailed business plan is the first step to develop goals and objectives that lead down a path towards sustainability. The definition of sustainability and the complexity of a sustainable business plan may differ for each biorepository. The DNASU Plasmid Repository at Arizona State University stores and distributes DNA plasmids to researchers worldwide, and the Biobank Core Facility at St. Joseph's Hospital and Barrow Neurological Institute consents patients and collects, stores, and distributes human tissue and blood samples. We will discuss these two biorepositories, their similar and different approaches to sustainability and business planning, their challenges in creating and implementing their sustainability plan, and their responses to some of these challenges. From these experiences, the biobanks share lessons learned about planning for sustainability that are applicable to all biorepositories.

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Biospecimen Use Correlates with Emerging Techniques in Cancer Research: Impact on Planning Future Biobanks

Cited by 24 publications

References 11 publications

Getting the message about biobanking: returning to the basics

Getting the message about biobanking: returning to the basics

A Framework for Biobank Sustainability

Sustainability in a Hospital-Based Biobank and University-Based DNA Biorepository: Strategic Roadmaps

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