Biosynthesis and characterization of antibacterial thermosensitive hydrogels based on corn silk extract, hyaluronic acid and nanosilver for potential wound healing

Makvandi, Pooyan; Ali, Ghareib W.; Sala, Francesca Della; Abdel-Fattah, Wafa I.; Borzacchiello, Assunta

doi:10.1016/j.carbpol.2019.115023

Cited by 174 publications

(107 citation statements)

References 41 publications

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“…Silver‐based nanocompounds are by far the most frequently used commercial nanoparticle [ 146 ] because of their potent antibacterial, antifungal and antiviral activities. [ 147–149 ] Silver nanostructures display potent antimicrobial activities that are comparable with Ag ions. [ 150 ] Silver and silver oxide (Ag 2 O) nanoparticles have diverse antibacterial applications in dentistry, [ 105,111,151 ] as scaffolds for tissue engineering [ 152,153 ] and as wound healing materials.…”

Section: Metal‐based Nanocompoundsmentioning

confidence: 99%

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Makvandi

Wang

Zare

et al. 2020

Adv Funct Materials

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518

368

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Microbial colonization on material surfaces is ubiquitous. Biofilms derived from surface-colonized microbes pose serious problems to the society from both an economical perspective and a health concern. Incorporation of antimicrobial nanocompounds within or on the surface of materials, or by coatings, to prevent microbial adhesion or kill the microorganisms after their attachment to biofilms, represents an important strategy in an increasingly challenging field. Over the last decade, many studies have been devoted to preparing meta-based nanomaterials that possess antibacterial, antiviral, and antifungal activities to combat pathogen-related diseases. Herein, an overview on the state-of-the-art antimicrobial nanosized metal-based compounds is provided, including metal and metal oxide nanoparticles as well as transition metal nanosheets. The antimicrobial mechanism of these nanostructures and their biomedical applications such as catheters, implants, medical delivery systems, tissue engineering, and dentistry are discussed. Their properties as well as potential caveats such as cytotoxicity, diminishing efficacy, and induction of antimicrobial resistance of materials incorporating these nanostructures are reviewed to provide a backdrop for future research.

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Section: Metal‐based Nanocompoundsmentioning

confidence: 99%

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Makvandi

Wang

Zare

et al. 2020

Adv Funct Materials

Self Cite

518

368

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show abstract

“…It could be of interest to compare the activity of HybenX ® with quaternary ammonium compounds and antimicrobial filler nanocompounds, also studied for dentistry applications [15,16]. Moreover, the broad spectrum antibacterial and antifungal activity of HybenX ® could be of interest for possible future uses with non-healing wounds, in epidemiological settings with a high prevalence of multi-drug resistant bacterial strains, or complicated with fungal infections, together with other promising antibacterials, such as silver nanoparticles [17]. In particular, HybenX ® proved to be more active against C. glabrata, even if the MBC was comparable to that observed with the other yeasts.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Antimicrobial Activity of the Decontaminant HybenX® Compared to Chlorhexidine and Sodium Hypochlorite against Common Bacterial and Yeast Pathogens

et al. 2019

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The recent increase in infections mediated by drug-resistant bacterial and fungal pathogens underlines the urgent need for novel antimicrobial compounds. In this study, the antimicrobial activity (inhibitory and cidal) of HybenX ® , a novel dessicating agent, in comparison with commonly used sodium hypochlorite and chlorhexidine, against a collection of bacterial and yeast strains representative of the most common human pathogenic species was evaluated. The minimal inhibitory, bactericidal, and fungicidal concentrations (MIC, MBC, and MFC, respectively) of the three different antimicrobial agents were evaluated by broth microdilution assays, followed by subculturing of suitable dilutions. HybenX ® was active against 26 reference strains representative of staphylococci, enterococci, Enterobacterales, Gram-negative nonfermenters, and yeasts, although at higher concentrations than sodium hypochlorite and chlorhexidine. HybenX ® MICs were 0.39% for bacteria (with MBCs ranging between 0.39% and 0.78%), and 0.1-0.78% for yeasts (with MFCs ranging between 0.78% and 1.6%). HybenX ® exhibited potent inhibitory and cidal activity at low concentrations against several bacterial and yeast pathogens. These findings suggest that HybenX ® could be of interest for the treatment of parodontal and endodontic infections and also for bacterial and fungal infections of other mucous membranes and skin as an alternative to sodium hypochlorite and chlorhexidine.

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“…They show high biocompatibility and safety for drug delivery applications [55]. Other carbohydrates, e.g., gum polysaccharides and hyaluronic acids (HA), with molecular weights higher than the previous saccharides, e.g., maltose, can be used in the matrix of MNs or as particles embedded in MNs [56][57][58][59]. Proteins, synthetic polymers, and polysaccharides exhibit high biocompatibility and degradability.…”

Section: Methodsmentioning

confidence: 99%

Progress in Microneedle-Mediated Protein Delivery

Jamaledin

Natale

Onesto

et al. 2020

JCM

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102

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The growing demand for patient-compliance therapies in recent years has led to the development of transdermal drug delivery, which possesses several advantages compared with conventional methods. Delivering protein through the skin by transdermal patches is extremely difficult due to the presence of the stratum corneum which restricts the application to lipophilic drugs with relatively low molecular weight. To overcome these limitations, microneedle (MN) patches, consisting of micro/miniature-sized needles, are a promising tool to perforate the stratum corneum and to release drugs and proteins into the dermis following a non-invasive route. This review investigates the fabrication methods, protein delivery, and translational considerations for the industrial scaling-up of polymeric MNs for dermal protein delivery.

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Biosynthesis and characterization of antibacterial thermosensitive hydrogels based on corn silk extract, hyaluronic acid and nanosilver for potential wound healing

Cited by 174 publications

References 41 publications

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

In Vitro Antimicrobial Activity of the Decontaminant HybenX® Compared to Chlorhexidine and Sodium Hypochlorite against Common Bacterial and Yeast Pathogens

Progress in Microneedle-Mediated Protein Delivery

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