Biosynthetic Pathway Engineering Strategies

Schmidt‐Dannert, Claudia; Pisarchik, Alexander

doi:10.1002/9783527634026.ch34

Protein Engineering Handbook 2008

DOI: 10.1002/9783527634026.ch34

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Biosynthetic Pathway Engineering Strategies

Claudia Schmidt‐Dannert

Alexander Pisarchik

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2011

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Genome shuffling: a method to improve biotechnological processes

Leja¹,

Myszka²,

Czaczyk³

2011

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Genome shuffling is widely used for increasing the production of metabolites by bacterial strains, improving substrate uptake as well as enhancing strain tolerance. This technique combines the advantage of multiparental crossing allowed by DNA shuffling together with the recombination of entire genomes normally associated with conventional breeding, or through protoplast fusion that increases the recombination process. The method of genome shuffling was first presented by Stemmer and co-workers in 2002 when it was used to improve the production of tylosin by Streptomyces fradiae. Nowadays, it is used in many experiments for increasing the production of metabolites by bacterial strains, improving substrate uptake, and enhancing strain tolerance. Genome shuffling is a major milestone in the strain-improvement technology and metabolic engineering.

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Genome shuffling: a method to improve biotechnological processes

Leja¹,

Myszka²,

Czaczyk³

2011

bta

View full text Add to dashboard Cite

show abstract

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Biosynthetic Pathway Engineering Strategies

Cited by 1 publication

References 136 publications

Genome shuffling: a method to improve biotechnological processes

Genome shuffling: a method to improve biotechnological processes

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