Biotechnological significance of toxic marine dinoflagellates

Camacho, F. Garcı́a; Rodríguez, J. Gallardo; Sánchez-Mirón, A.; Cerón-García, M.C.; Belarbi, El Hassan; Chisti, Yusuf; Grima, E. Molina

doi:10.1016/j.biotechadv.2006.11.008

Cited by 169 publications

(123 citation statements)

References 179 publications

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“…Although many compounds isolated from dinoflagellates have shown bioactivities of interest (Camacho et al, 2007;Blunt et al, 2011), only a few have led to commercial products (Gallardo-Rodríguez et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Bioactive compounds from dinoflagellates have received increased attention because of their impact on the safety of seafood and their potential uses in biomedical, toxicological and pharmacological research. Despite the many interesting bioactive compounds isolated from dinoflagellates (Konishi et al, 2004;Camacho et al, 2007;Blunt et al, 2011), only a few have led to commercial products. This is partly due to the limited amount of dinoflagellate toxin that can be amassed for detailed clinical evaluation (Gallardo-Rodríguez et al, 2012).…”

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confidence: 99%

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The inhibitory effect of a non-yessotoxin-producing dinoflagellate, Lingulodinium polyedrum (Stein) Dodge, towards Vibrio vulnificus and Staphylococcus aureus

Quijano-Scheggia

Barajas-Gonzalez

Lim

et al. 2016

RBT

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Abstract:The increased bacterial resistance to antibiotics has caused global concern, prompting the search for new compounds. Because of their abundance and diversity, marine phytoplankton are an important potential source of such compounds. Research on dinoflagellates has led to the discovery of inhibitors of bacterial growth. The marine dinoflagellate Lingulodinium polyedrum blooms in different regions of the world, including Mexico, and is also known to regulate the growth of other species in coastal waters. Here, we investigated the taxonomy of this dinoflagellate and characterized the ability of its extracts to inhibit the growth of two bacteria of medical importance (Vibrio vulnificus and Staphylococcus aureus). Taxonomic characterization was performed by PCR and gene amplification of ITS, and confirmed that the species isolated off the Pacific coast of Mexico was L. polyedrum. To prove the inhibitory effect of L. polyedrum extracts, cultures were harvested by centrifugation. Pellets from three cellular abundances were extracted with water, methanol, hexane and chloroform. The experiments on V. vulnificus showed a high growth inhibition for the four extracts, ranging from 77 to 98 %. Surprisingly, the growth inhibition was lower when the extracts originated from a higher L. polyedrum cell abundance, ranging from 0 to 34 %. For S. aureus, the growth inhibition was also high, but not statistically different for all extracts and cell abundances, ranging from 62 to 99 %. This study obtained promising results for future pharmacological applications. Our Mexican strain of L. polyedrum did not produce any detectable yessotoxins. Rev. Biol. Trop. 64 (2): 805-816. Epub 2016 June 01.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

The inhibitory effect of a non-yessotoxin-producing dinoflagellate, Lingulodinium polyedrum (Stein) Dodge, towards Vibrio vulnificus and Staphylococcus aureus

Quijano-Scheggia

Barajas-Gonzalez

Lim

et al. 2016

RBT

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“…Over the years, only a few studies have been done in evaluating the specific bioactivities of cultured dinoflagellates (Camacho et al, 2007;Nakagawa et al, 1998). They have been recognized as potential sources bearing novel compounds for appraisal as pharmaceuticals (Camacho et al, 2007;Dragunow et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…They have been recognized as potential sources bearing novel compounds for appraisal as pharmaceuticals (Camacho et al, 2007;Dragunow et al, 2005). Moreover, bioactive components are gaining the interest of researchers because of their potential usefulness in many applications.…”

Section: Introductionmentioning

confidence: 99%

“…Toxic metabolites have been reported from cultured dinoflagellates and are considered as valuable laboratory tools in the case of drug discovery (Elbrächter and Faust, 2002;Nakajima et al, 1981). Hence, bioactive components can be isolated from benthic dinoflagellates and rendered in a range of biological activities, including cytotoxic, antitumor, antibiotic, antifungal, immunosuppressant and neurotoxic (Camacho et al, 2007;Wright and Cembella, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Potentiality of benthic dinoflagellate cultures and screening of their bioactivities in Jeju Island, Korea

Shah¹,

Kalpa²,

Ju-Young³

et al. 2014

Afr. J. Biotechnol.

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Polyketide Biosynthesis: Polyethers

Hill

2008

Wiley Encyclopedia of Chemical Biology

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This review covers the biosynthesis of terrestrial and marine polyethers and discusses their biologic properties and the molecular genetics and enzymology of the proteins responsible for their formation. The biosynthesis of monensin, nanchangmycin, nonactin, and the marine polyether ladders are discussed in detail. Novel enzymes found only in type I polyketide polyether gene clusters that are responsible for the epoxidation and cyclization of polyene biosynthetic intermediates are described. The macrotetrolide biosynthetic gene cluster, which is an ACP‐less type II polyketide synthase that functions noniteratively is reviewed.

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Biotechnological significance of toxic marine dinoflagellates

Cited by 169 publications

References 179 publications

The inhibitory effect of a non-yessotoxin-producing dinoflagellate, Lingulodinium polyedrum (Stein) Dodge, towards Vibrio vulnificus and Staphylococcus aureus

The inhibitory effect of a non-yessotoxin-producing dinoflagellate, Lingulodinium polyedrum (Stein) Dodge, towards Vibrio vulnificus and Staphylococcus aureus

Potentiality of benthic dinoflagellate cultures and screening of their bioactivities in Jeju Island, Korea

Polyketide Biosynthesis: Polyethers

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