Biotechnology of Magnet-Driven Liposome Preparations

Ismailova, G. K.; Efremenko, V. I.; Kuregyan, A. G.

doi:10.1007/s11094-005-0162-4

Cited by 8 publications

(8 citation statements)

References 3 publications

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“…They may encapsulate a large amount of drugs in their inner core, increasing the duration of the drug action, reducing drug toxicity, protecting them from factors that could inactivate them, and ensuring a prolonged release of the drugs. 24 A challenge in drug delivery would then consist of combining the advantages of liposomes and magnetic np's by making lipidbased vesicles containing magnetic np's. Nanoparticles would add new functionalities to liposomes, allowing organ targeting by magnetic field induced-transport, vesicle imaging by MRI, and drug delivery triggering by hyperthermia, whereas the lipidbased vehicle would ensure biocompatibility, a large amount of transported drug, and drug protection.…”

Section: Introductionmentioning

confidence: 99%

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Magnetic Multilamellar Liposomes Produced by In Situ Synthesis of Iron Oxide Nanoparticles: “Magnetonions”

et al. 2009

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We report the formation of magnetic onion-type multilamellar vesicles. Iron oxide nanoparticles (np's) were synthesized inside lipidic multilamellar vesicles by coprecipitation of vesicle-encapsulated Fe(2+) and Fe(3+) ions induced by HO(-) diffusion through vesicle lamellae. The iron ion encapsulation efficiency of onions was measured by potentiometry and UV-vis absorbance spectroscopy. Its high value (75 +/- 5% for both Fe(2+) and Fe(3+)) ensures an intravesicular synthesis, as confirmed by cryo-transmission electron microscopy (TEM) imaging. The as-grown nanoparticles are characterized by X-ray diffraction analysis and TEM, and magnetic onions are imaged by cryo-TEM. The np size, controlled by temperature and time, ranges from 3 to 6 nm and is shown to be a key parameter for onion stability.

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Section: Introductionmentioning

confidence: 99%

“…Liposomes are, indeed, chemically inert, and then biocompatible and biodegradable. They may encapsulate a large amount of drugs in their inner core, increasing the duration of the drug action, reducing drug toxicity, protecting them from factors that could inactivate them, and ensuring a prolonged release of the drugs …”

Section: Introductionmentioning

confidence: 99%

Magnetic Multilamellar Liposomes Produced by In Situ Synthesis of Iron Oxide Nanoparticles: “Magnetonions”

et al. 2009

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“…Liposome ensures the targeted delivery of substances encapsulated in the vesicles such as drugs and provide for a prolonged release of such substances. The increasing interest in liposome is related to the unique combination of their physicochemical and biological properties manifested both in -vitro and in-vivo 3 .…”

Section: Quick Response Codementioning

confidence: 99%

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2015

IJPSR

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The biological synthesis of magnetite nano-bio hybrid using plant extracts plays an important role in the field of nanotechnology. The present study demonstrates bio-reductive synthesis of protein coated magnetite (Fe 3 O 4) nano-bio hybrid using leaf extracts of Datura inoxia plants and its encapsulation into liposome. Liposome is vesicles of varying size consisting of a spherical lipid bilayer and an aqueous inner compartment that are generated in vitro. Magnet-driven liposome used for the targeted delivery of drugs to organs and tissues. These liposome preparations contain encapsulated drug components and finely dispersed magnetic particles inside the liposome. Liposome is useful in terms of biocompatibility, biodegradability, low toxicity and can control bio distribution by changing the size, lipid composition, and physical characteristics. Furthermore, liposome can entrap both hydrophobic and hydrophilic drugs and are able to continuously release the entrapped substrate, thus being useful drug carriers. The nano bio hybrid based magneto liposome has been prepared by reversed phase evaporation (REV) method using oleic and linoleic acid which has been shown to be driven under magnetic field. The magneto liposome was characterized by chemically using potassium thiocyanate (KSCN) and confirmed by UV-Vis spectrophotometer Cary 60, Agilent. Magnetic liposome has an advantage over free magnetic nanocores as various functional groups can be attached to the surface of liposome for ligand-specific targeting. Such aspects of magnetically-driven liposome preparations can be used for the targeted delivery of drugs to organs and tissues.

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“…This problem has been considered in a number of works (see reviews [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]) devoted mainly to bio detection/biosensitivity [1][2][3] (plasmon resonant properties of gold and silver nanoparticles are used in this field [16,17]) and cancer treatment. In the latter case, gold [4][5][6][7] and silver [8] NPs, as well as magnetic particles [9,[18][19][20], are mainly used as carriers of drugs [4, 5, 9-11, 14, 18-20] and intensifiers of physiotherapeutic treatment methods-radiation, photodynamic, and photothermal therapy [3,6,7,12,[21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Heterocoagulation of polysaccharide-coated platinum nanoparticles with ovarian-cancer cells

et al. 2014

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Platinum nanoparticles coated with adsorption layers of polysaccharides of Chlorella vulgaris (Pt PS ) have been synthesized and their heterocoagulation with human ovarian cancer cells of the A2780 line has been studied. It has been shown that the characteristic time of the aggregation of the cells with Pt PS nano particles is 20-25 min, which corresponds to fast barrierless coagulation. The cytotoxic effect of Pt PS nano particles reaches saturation and more than 50% of the cells die within this time period. Cytomorphological investigations have shown that A2780 cells with doubled resistance to an antitumoral antibiotic, doxorubicin, are more sensitive to the toxic action of Pt PS nanoparticles than nonresistant cells are. An electrokinetic con trol test has been proposed for cancer cell resistance based on the measurement of variations in the ζ poten tial of nanoparticles due to adsorption of water soluble metabolites of the cells on a particle surface.

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Biotechnology of Magnet-Driven Liposome Preparations

Cited by 8 publications

References 3 publications

Magnetic Multilamellar Liposomes Produced by In Situ Synthesis of Iron Oxide Nanoparticles: “Magnetonions”

Magnetic Multilamellar Liposomes Produced by In Situ Synthesis of Iron Oxide Nanoparticles: “Magnetonions”

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Heterocoagulation of polysaccharide-coated platinum nanoparticles with ovarian-cancer cells

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