Biotransformation of 6α-santonin and 1,2-dihydro-α-santonin by Acremonium chrysogenum PTCC 5271 and Rhizomucor pusillus PTCC 5134

Gandomkar, Somayyeh; Habibi, Zohreh

doi:10.1016/j.molcatb.2014.09.003

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…A. chrysogenum gave four metabolites from α-santonin, including 1,2-dihydro-α-santonin, while R. pusillus gave rise to two metabolites. The same strains were incubated also with 1,2-dihydro-α-santonin where both afforded tetrahydro-α-santonin and tetrahydroartemisinin in different ratios [129].…”

Section: Substrate Additionmentioning

confidence: 99%

Microbial Transformations of Plant Secondary Metabolites

Mutafova¹,

Fernandes²,

Mutafov³

et al. 2016

Bioprocessing of Plant in Vitro Systems

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The aim of this chapter is to present the authors' view on the place and role of microbial transformation reactions as a perspective means of processing of plantderived biologically active compounds into metabolites with new and/or increased activity and availability and decreased toxicity. Some microbial transformations providing information regarding metabolism in humans and mammals of plant-derived secondary metabolites applied as drugs and/or food additives are also considered.

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Section: Substrate Additionmentioning

confidence: 99%

Microbial Transformations of Plant Secondary Metabolites

Mutafova¹,

Fernandes²,

Mutafov³

et al. 2016

Bioprocessing of Plant in Vitro Systems

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“…Another possibility is the direct hydroxylation of the double bond [ 11 , 13 , 14 , 16 , 18 ] or opening of an epoxide ring [ 11 , 15 , 18 ]. The hydroxy group can also be introduced into primary [ 19 ], secondary [ 16 , 19 , 20 ] or tertiary carbons of the molecules [ 12 , 17 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biotransformation of Bicyclic Unsaturated Lactones with Three or Four Methyl Groups

et al. 2017

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The aim of this study was to obtain new unsaturated lactones by chemical synthesis and their microbial transformations using fungal strains. Some of these strains were able to transform unsaturated lactones into different hydroxy or epoxy derivatives. Strains of Syncephalastrum racemosum and Absidia cylindrospora gave products with a hydroxy group introduced into a tertiary carbon, while the Penicillium vermiculatum strain hydroxylated primary carbons. The Syncephalastrum racemosum strain hydroxylated both substrates in an allylic position. Using the Absidia cylindrospora and Penicillium vermiculatum strains led to the obtained epoxylactones. The structures of all lactones were established on the basis of spectroscopic data.

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“…(such as oxidation, reduction, conjugation and degradation) can be catalyzed by microorganisms more easily (Gandomkar and Habibi 2014). Microbial biotransformation is a unique and inexpensive way to obtain bioactive natural products.…”

Section: Introductionmentioning

confidence: 99%