Biotransformation of pentacyclic terpene isolated from<i>Alstonia scholaris (R.BR.)</i>

Qazi, Muhammad Saleem; Sultana, Nighat; Kamal, Mustafa

doi:10.3109/10242422.2013.801016

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…Among Microsporum canis, Trichophyton tonsurans, Aspergillus niger, A. niger NIAB-280 and Penicillium spp. , M. canis and T. tonsurans showed strong transformation ability [ 46 ]. However, the exact BA yield was not revealed in the report.…”

Section: Preparation Of Betulinic Acidmentioning

confidence: 99%

“…Feng et al [45] discovered that C. blakesleeana AS 3.910 was capable of transforming betulin into BA and optimized several parameters of the fermentation process. Qazi et al [46] also screened five kinds of fungi to select strains that were capable of transforming betulin to BA. Among Microsporum canis, Trichophyton tonsurans, Aspergillus niger, A. niger NIAB-280 and Penicillium spp., M. canis and T. tonsurans showed strong transformation ability [46].…”

Section: Biotransformation Process 231 Biotransformation By Fungi Systemmentioning

confidence: 99%

“…Qazi et al [46] also screened five kinds of fungi to select strains that were capable of transforming betulin to BA. Among Microsporum canis, Trichophyton tonsurans, Aspergillus niger, A. niger NIAB-280 and Penicillium spp., M. canis and T. tonsurans showed strong transformation ability [46]. However, the exact BA yield was not revealed in the report.…”

Section: Biotransformation Process 231 Biotransformation By Fungi Systemmentioning

confidence: 99%

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A Review on Preparation of Betulinic Acid and Its Biological Activities

Lou

Zhang

et al. 2021

Molecules

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Betulinic acid, a pentacyclic triterpene, is distributed in a variety of plants, such as birch, eucalyptus and plane trees. It shows a wide spectrum of biological and pharmacological properties, such as anti-inflammatory, antibacterial, antiviral, antidiabetic, antimalarial, anti-HIV and antitumor effects. Among them, the antitumor activity of betulinic acid has been extensively studied. However, obtaining betulinic acid from natural resources can no longer meet the needs of medicine and nutrition, so methods such as chemical synthesis and microbial biotransformation have also been used to prepare betulinic acid. At the same time, with the development of synthetic biology and genetic engineering, and the elucidation of the biosynthetic pathways of terpenoid, the biosynthesis of betulinic acid has also been extensively researched. This article reviews the preparation of betulinic acid and its pharmacological activities, in order to provide a reference for the research and utilization of betulinic acid.

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Section: Preparation Of Betulinic Acidmentioning

confidence: 99%

Section: Biotransformation Process 231 Biotransformation By Fungi Systemmentioning

confidence: 99%

Section: Biotransformation Process 231 Biotransformation By Fungi Systemmentioning

confidence: 99%

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A Review on Preparation of Betulinic Acid and Its Biological Activities

Lou

Zhang

et al. 2021

Molecules

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Microbial Transformations of Pentacyclic Triterpenes

Azerad

2016

Green Biocatalysis

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Separation and purification of plant terpenoids from biotransformation

Chen

Pang

Luo

et al. 2021

Engineering in Life Sciences

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The production of plant terpenoids through biotransformation has undoubtedly become one of the research hotspots, and the continuous upgrading of the corresponding downstream technology is also particularly important. Downstream technology is the indispensable technical channel for the industrialization of plant terpenoids. How to efficiently separate high‐purity products from complex microbial fermentation broths or enzyme‐catalyzed reactions to achieve high separation rates, high returns and environmental friendliness has become the focus of research in recent years. This review mainly introduces the common separation methods of plant terpenoids based on biotransformation from the perspectives of engineering strain construction, unit separation technology, product properties and added value. Then, further attention was paid to the application prospects of intelligent cell factories and control in the separation of plant terpenoids. Finally, some current challenges and prospects are proposed, which provide possible directions and guidance for the separation and purification of terpenoids and even industrialization.

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Biotransformation of pentacyclic terpene isolated fromAlstonia scholaris (R.BR.)

Cited by 5 publications

References 10 publications

A Review on Preparation of Betulinic Acid and Its Biological Activities

A Review on Preparation of Betulinic Acid and Its Biological Activities

Microbial Transformations of Pentacyclic Triterpenes

Separation and purification of plant terpenoids from biotransformation

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