Birth weight correlates with size but not shape of the normal human placenta

Haeussner, Eva; Schmitz, Christoph; Koch, Franz; Frank, Hans-Georg

doi:10.1016/j.placenta.2013.04.011

Cited by 46 publications

(31 citation statements)

References 24 publications

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“…The absolute volumes of the villous tree and intervillous space calculated from the respective volume densities (using placental weight and the average density of placental tissue, for details see methods section) correlated statistically significantly with PW, BW, and PW/BW (data not shown). However, it should be noted that these correlations of the absolute volumes with PW, BW, and PW/BW are due to usage of PW as a factor in the calculation of the volume density raw data; PW, BW, and PW/BW correlate with each other24 and thus also with the absolute volumes.…”

Section: Resultsmentioning

confidence: 99%

Novel 3D Microscopic Analysis of Human Placental Villous Trees Reveals Unexpected Significance of Branching Angles

Haeussner

Buehlmeyer

Schmitz

et al. 2014

Sci Rep

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The villous trees of human placentas delineate the fetomaternal border and are complex three-dimensional (3D) structures. Thus far, they have primarily been analyzed as thin, two-dimensional (2D) histological sections. However, 2D sections cannot provide access to key aspects such as branching nodes and branch order. Using samples taken from 50 normal human placentas at birth, in the present study we show that analysis procedures for 3D reconstruction of neuronal dendritic trees can also be used for analyzing trees of human placentas. Nodes and their branches (e.g., branching hierarchy, branching angles, diameters, and lengths of branches) can be efficiently measured in whole-mount preparations of isolated villous trees using high-end light microscopy. Such data differ qualitatively from the data obtainable from histological sections and go substantially beyond the morphological horizon of such histological data. Unexpectedly, branching angles of terminal branches of villous trees varied inversely with the fetoplacental weight ratio, a widely used clinical parameter. Since branching angles have never before been determined in the human placenta, this result requires further detailed studies in order to fully understand its impact.

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Section: Resultsmentioning

confidence: 99%

Novel 3D Microscopic Analysis of Human Placental Villous Trees Reveals Unexpected Significance of Branching Angles

Haeussner

Buehlmeyer

Schmitz

et al. 2014

Sci Rep

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“…Placenta weight is a reliable predictor of postnatal health and it shows positive correlations with birth weight [11][12][13][14]. Haeussner et al showed that shape and size of the placenta have different functional meanings and can be determined independently; where birth weight correlates with size (weight) but not shape of the normal placenta [11].…”

Section: Discussionmentioning

confidence: 99%

“…Haeussner et al showed that shape and size of the placenta have different functional meanings and can be determined independently; where birth weight correlates with size (weight) but not shape of the normal placenta [11].…”

Section: Discussionmentioning

confidence: 99%

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Correlations of morphometric placental microvessels parameters with birth weight.

Boruah

Mohanlal

Malik

et al. 2017

AAMS

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Introduction: Birth weight (BWT) is greatly affected by placental insufficiency and the microvessels configurations. Aims of this study were to evaluate various parameters: villous density (VD), microvessel density (MVD), microvessels per villus (MVPV), mean microvessel caliber (VC), total microvessels boundary density (TVBD), maximum possible total length of microvessels (MP-TVL) and maximum possible total surface area of microvessels (MP-TVSA) in terminal villi of placenta. All the parameters including placental weight (PWT) were correlated with BWT; and MVD and VC of placenta were compared with the human tissues from various lesions. Materials and methods:Sixty human placentas of uncomplicated term pregnancies (≥37weeks) managed at this tertiary care institute were included. Formalin fixed paraffin embedded sections of placental tissues were used for computer assisted digital image morphometry. H&E stained sections were used to determine VD and CD34 immuno-stained sections were used for evaluation of vascular parameters in terminal villi. Results: The mean VD was 204 mm-2, the mean MVD was 1314 mm-2, the mean MVPV was 6.6, the mean MVC was 10.15 µm, the mean TVBD was 40.64 mm-1, the mean MP-TVL was 626 km and the mean MP-TVSA was 19.23 m2. The BWT showed significant (p<0.05) positive correlations with PWT (r=0.690), VD (r=0.328), MVD (r=0.408), TVBD (r=0.280), MP-TVL (r=0.723) and MP-TVSA (r=0.723); whereas did not show significant correlations with MVPV (r=0.185, p=0.157) and VC (r=-0.249, p=0.054). MVD in placentas showed strong negative correlation with VC (r=-0.712). MVD in placentas were several times (~ 6.3 times) higher than human tissues; though mean caliber of microvessels in placenta was comparable. Conclusion:PWT, VD, MVD and TVBD in placenta showed significant positive correlations with BWT. Estimated MP-TVL and MP-TSA showed the best correlations with BWT. Placental MVD showed strong negative correlation with VC. Total length of microvessels in the placenta was comparable to that estimated for the fetus. Keywords: Microvessels in

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“…Fetal growth is dependent on nutrient transportation across the placenta. Placental size, structure and function are correlated with the capacity for nutrient transfer, and all increase steadily throughout gestation [11]. Toxic compounds in tobacco smoke, such as nicotine, carbon monoxide, polycyclic aromatic hydrocarbons, nitroso compounds, cadmium and thiocyanate, may cause oxidative stress, vasopressor effects, endothelial dysfunction, vascular injury, increased arterial stiffness and markers of inflammation.…”

Section: Discussionmentioning

confidence: 99%

Placenta mediates the association between maternal second-hand smoke exposure during pregnancy and small for gestational age

et al. 2015

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Birth weight correlates with size but not shape of the normal human placenta

Cited by 46 publications

References 24 publications

Novel 3D Microscopic Analysis of Human Placental Villous Trees Reveals Unexpected Significance of Branching Angles

Novel 3D Microscopic Analysis of Human Placental Villous Trees Reveals Unexpected Significance of Branching Angles

Correlations of morphometric placental microvessels parameters with birth weight.

Placenta mediates the association between maternal second-hand smoke exposure during pregnancy and small for gestational age

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