Bis-diglycerylpolyacyladipate-2: An emergent allergen in cosmetics?

PEG‐45/dodecyl glycol co‐polymer and bis‐diglyceryl polyacyladipate‐2: Two culprits responsible of an allergic contact dermatitis to a lip balm

“…It is a commonly used ingredient in many cosmetics (more than 500 products) as an ointment base and lanolin substitute. We reported, a few years ago, a case of allergic contact cheilitis due to bis‐diglyceryl polyacyladipate‐2 present in a lipstick 7 . Some authors suggested to perform patch tests with its constituent fatty acids, especially 12‐hydroxystearic acid, in order to confirm the latter molecule to be the actual allergen 8 .…”

“…We reported, a few years ago, a case of allergic contact cheilitis due to bis-diglyceryl polyacyladipate-2 present in a lipstick. 7 Some authors suggested to perform patch tests with its constituent fatty acids, especially 12-hydroxystearic acid, in order to confirm the latter molecule to be the actual allergen. 8 Unfortunately, this molecule was not available to us.…”

Allergic contact dermatitis caused by bis-diglycerylpolyacyladipate-2 (Softisan® 649) owing to its 12-hydroxystearic acid content

“…Du‐Thanh et al recently published in Contact Dermatitis what they described as the first reported patient with allergic contact dermatitis caused by bis‐diglycerylpolyacyladipate‐2 (Softisan® 649) and postulated that it may be an ‘emerging allergen’(1).…”

“…The authors of the recent paper (1) suggest that bis‐diglycerylpolyacyladipate‐2 might be an ‘emerging allergen’. In any patient allergic to bis‐diglycerylpolyacyladip ate‐2, it would be informative to perform patch tests with its constituent fatty acids, especially 12‐hydroxystearic acid, in order to confirm if the latter is the actual underlying allergen, as it was in our patient (2).…”