Bisabolane, Oplopane, and Lignan Constituents of Cremanthodium campanulatum Collected in China

Abstract

The chemical constituents in the roots of 3 Cremanthodium campanulatum Diels (Asteraceae) samples collected in Yunnan and Sichuan Provinces, China, were chemically investigated. A total of 8 bisabolane-type sesquiterpenoids, 2 of which were new, and a new oplopane-type sesquiterpenoid, along with a new lignan were isolated and their structures elucidated based on spectroscopic analyses. This is the first report on the chemical study of C. campanulatum.

Chemical Studies of Cremanthodium (Asteraceae) Species; Sesquiterpenoids and Related Compounds

“…Bisabolane-type sesquiterpenoids were isolated as the major components. 11 Interestingly, no eremophilane was detected in either C. campanulatum or L. lankongensis, suggesting that the 2 species belong to the same chemical lineage.…”

“…Bisabolane-type sesquiterpenoids were isolated as the major components. 11 From sample 13, compounds 38 , 41 , and 77 were isolated. From sample 14, compounds 38 , 39 , 41 , 42 , 62 , and 77 were isolated.…”

“…Both styles A (C-6α substituent) 18,21 and B (C-6β substituent) are employed in the literatures. 11,30,31 Structure C is the enantiomer of A (= B ). However, because it is not likely to occur enantiomeric carbon skeleton in nature, the difference between B and C can be attributed to the difference in substituents.…”

“…Compound 42 was the strongest (half-maximal inhibitory concentration 1.51 µM) among the 8 compounds 38 to 45 . 11…”