Bisphenol-A exposure in utero programs a sexually dimorphic estrogenic state of hepatic metabolic gene expression

Ilagan, Ysabel; Mamillapalli, Ramanaiah; Goetz, Teddy G.; Kayani, Jehanzeb; Taylor, Hugh S.

doi:10.1016/j.reprotox.2017.05.001

Cited by 22 publications

(6 citation statements)

References 82 publications

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“…Indeed, the maternal period has been found to be a highly vulnerable period [57,58]. For example, it was demonstrated that hepatic metabolic gene expression in adult mice including Esr1 was strongly impacted in mice exposed in utero to BPA as compared to control mice [59]. In addition, the vulnerability of the fetal period towards exposure to the presently used mixture of pollutants has been evidenced in male mice [50].…”

Section: Discussionmentioning

confidence: 99%

Estrogen withdrawal and replacement differentially target liver and adipose tissues in female mice fed a high-fat high-sucrose diet: impact of a chronic exposure to a low-dose pollutant mixture☆

Julien

Pinteur

Véga

et al. 2019

The Journal of Nutritional Biochemistry

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HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. 1 Estrogen withdrawal and replacement differentially target liver and adipose tissues in female mice fed a high-fat high-sucrose diet. Impact of a chronic exposure to a low-dose pollutant mixture.

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Section: Discussionmentioning

confidence: 99%

Estrogen withdrawal and replacement differentially target liver and adipose tissues in female mice fed a high-fat high-sucrose diet: impact of a chronic exposure to a low-dose pollutant mixture☆

Julien

Pinteur

Véga

et al. 2019

The Journal of Nutritional Biochemistry

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“…Moreover, in utero BPA exposure had a dimorphic effect in mice livers, increasing oestrogen receptors and 17α-hydrolase in females but reducing them in males. On the contrary, cyclooxygenase 1 was decreased in the liver of female mice but increased in male mice 79 …”

Section: Passive Strategy Against Ncds: Negative In Utero Programmingmentioning

confidence: 84%

“…On the contrary, cyclooxygenase 1 was decreased in the liver of female mice but increased in male mice. 79 The underlying mechanisms of BPA's negative effect on in utero programming and NCDs development are controversial. One study showed that BPA exposure in utero in mice did not affect DNA methylation of the liver in offspring.…”

Section: Environmental Chemicalsmentioning

confidence: 99%

Strategies to reduce non-communicable diseases in the offspring: negative and positivein uteroprogramming

Rodriguez-Caro

Williams

2018

J Dev Orig Health Dis

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Non-communicable diseases (NCDs) are a major problem as they are the leading cause of death and represent a substantial economic cost. The 'Developmental Origins of Health and Disease Hypothesis' proposes that adverse stimuli at different life stages can increase the predisposition to these diseases. In fact, adverse in utero programming is a major origin of these diseases due to the high malleability of embryonic development. This review provides a comprehensive analysis of the scientific literature on in utero programming and NCDs highlighting potential medical strategies to prevent these diseases based upon this programming. We fully address the concept and mechanisms involved in this programming (anatomical disruptions, epigenetic modifications and microbiota alterations). We also examine the negative role of in utero programming on the increased predisposition of NCDs in the offspring, which introduces the passive medical approach that consists of avoiding adverse stimuli including an unhealthy diet and environmental chemicals. Finally, we extensively discuss active medical approaches that target the causes of NCDs and have the potential to significantly and rapidly reduce the incidence of NCDs. These approaches can be classified as direct in utero programming modifications and personalized lifestyle pregnancy programs; they could potentially provide transgenerational NCDs protection. Active strategies against NCDs constitute a promising tool for the reduction in NCDs.

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“…Serum/glucocorticoid-regulated kinase 1 expression is elevated in primary liver cancer (Ilagan et al 2017). BPA affects liver functions that are evident by the reduction in the activities of several enzymes, including catalase, glutathione, and others (Aboul Ezz et al 2015).…”

Section: Hepatic Cancermentioning

confidence: 99%

A comprehensive review on the carcinogenic potential of bisphenol A: clues and evidence

Khan

Correia

Adiga

et al. 2021

Environ Sci Pollut Res

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Bisphenol A [BPA; (CH3)2C(C6H4OH)2] is a synthetic chemical used as a precursor material for the manufacturing of plastics and resins. It gained attention due to its high chances of human exposure and predisposing individuals at extremely low doses to diseases, including cancer. It enters the human body via oral, inhaled, and dermal routes as leach-out products. BPA may be anticipated as a probable human carcinogen. Studies using in vitro cell lines, rodent models, and epidemiological analysis have convincingly shown the increasing susceptibility to cancer at doses below the oral reference dose set by the Environmental Protection Agency for BPA. Furthermore, BPA exerts its toxicological effects at the genetic and epigenetic levels, influencing various cell signaling pathways. The present review summarizes the available data on BPA and its potential impact on cancer and its clinical outcome.

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Bisphenol-A exposure in utero programs a sexually dimorphic estrogenic state of hepatic metabolic gene expression

Cited by 22 publications

References 82 publications

Estrogen withdrawal and replacement differentially target liver and adipose tissues in female mice fed a high-fat high-sucrose diet: impact of a chronic exposure to a low-dose pollutant mixture☆

Estrogen withdrawal and replacement differentially target liver and adipose tissues in female mice fed a high-fat high-sucrose diet: impact of a chronic exposure to a low-dose pollutant mixture☆

Strategies to reduce non-communicable diseases in the offspring: negative and positivein uteroprogramming

A comprehensive review on the carcinogenic potential of bisphenol A: clues and evidence

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