Bisphosphonate treatment and the risk of atypical femoral fracture among patients participating in a Fracture Liaison Service of a tertiary medical center

Exercise Prescription for Osteoporosis: Back to Basics

“…Traditionally, first-line treatment for osteoporosis is medication; however, compliance is notoriously poor and efficacy is far from universal. Adverse events, although relatively rare, can be serious (6), and discontinuation of certain medication is associated with rapid bone loss and increased risk of fracture (7,8). Harnessing the natural capacity of bone to optimize its strength through exercise, a therapy with few nonresponders or side effects, is an obvious alternative strategy to manage osteoporosis.…”

Asia-Pacific consensus on long-term and sequential therapy for osteoporosis

“…As a chronic condition, osteoporosis necessitates long-term management, but patient adherence to long-term drug regimens remains unsatisfactory [ 4 , 5 ]. Additionally, certain therapies have notable adverse effects, ranging from musculoskeletal discomfort to rare but severe complications, such as medication-related osteonecrosis of the jaw (MRONJ) and atypical femoral fractures (AFFs), when used for prolonged use [ 6 , 7 ]. Evaluating the strengths, limitations, and long-term benefit-to-risk ratios of each medication is crucial, as is a specific focus on advancements in long-term and sequential treatment strategies.…”