Bitter steroid glucosides, vernoniosides A1, A2, and A3, and related B1 from a possible medicinal plant, Vernonia amygdalina, used by wild chimpanzees.

Jisaka, Mitsuo; Ohigashi, Hajime; Takagaki, Teruyoshi; Nozaki, Hirōshi; Tada, Toshiji; Hirota, Mitsuru; Irie, Ryozo; Huffman, Michael A.; Nishida, Toshida; Kaji, Mikio; Koshimįzu, Koichi

doi:10.1016/s0040-4020(01)88123-0

Cited by 138 publications

(107 citation statements)

References 6 publications

Supporting

Mentioning

103

Contrasting

Order By: Relevance

“…Flavonoids are most commonly known for their antioxidant activity and act as transformers which modify the body's reactions to carcinogens, viruses and allergens. They possess anti-cancerous, anti-inflammatory, anti-microbial and anti-allergic activity (Balch and Balch, 2000) and may, therefore be useful in therapeutic roles (Jisaka et al, 1992). Terpenoids are antifungal and Res.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Screening, Antifungal and Antibacterial Activity of Aqueous and Ethanolic Leaf and Stem Extracts of Gnetum africanum Welw

Ilodibia¹,

Ugwu²,

Nwokolo³

et al. 2015

Research J. of Medicinal Plant

View full text Add to dashboard Cite

Aqueous and ethanolic leaf and stem extracts of Gnetum africanum were investigated for the presence and composition of these phytochemicals (alkaloid, flavonoid, tannin, phenol, saponin, sterol, terpenoid and cyanogenic glycoside) and their antifungal and antibacterial activities at various concentrations against some selected clinical microbes (fungal strains: Candida albicans and Aspergillus niger and bacterial strains: Staphylococcus aureus, Escherichia coli and Salmonella typhi) using standard methods. Analysis of variance (ANOVA) was employed in data analysis. Qualitative and percent quantitative phytochemical results showed that both the aqueous and ethanolic leaf and stem extracts contained these phytochemicals assayed but at varied quantities except cyanogenic glycoside. Antifungal and antibacterial studies indicated that both the aqueous and ethanolic leaf and stem extracts of Gnetum africanum inhibited the growth of the microbes but at varied levels and the inhibition was extracts concentration dependent. However, both the aqueous and ethanolic leaf and stem extracts showed no inhibition against the bacterial strains at 50 mg mLG 1 of the extracts. The extracts showed higher inhibition against the fungal strains than the bacterial strains. Inhibitory effect of the leaf extract was significantly higher than those of the stem extract. The ethanol extract showed significantly higher inhibition than the aqueous extract. Antibiotics had a better activity when compared to the extracts at the same concentration. Gnetum africanum extracts were biostatic in their action, when purified will give a product with higher activity. The data obtained from the study indicated that the plant possessed antifungal and antibacterial potentials especially antifungal and could be used as natural fungicides.

show abstract

Section: Discussionmentioning

confidence: 99%

Phytochemical Screening, Antifungal and Antibacterial Activity of Aqueous and Ethanolic Leaf and Stem Extracts of Gnetum africanum Welw

Ilodibia¹,

Ugwu²,

Nwokolo³

et al. 2015

Research J. of Medicinal Plant

View full text Add to dashboard Cite

show abstract

“…Calculations were performed to illustrate the involvement and contributions of some major chemical constituents of VA, including vernodalin and luteoline [24,26] to the corrosion inhibition process. This was achieved using the Materials Studio 4.0 software (BIOVIA Inc.) Electronic structure modeling was achieved in DMol 3 workspace, using a Mulliken population analysis, the DND basis set and the Perdew-Wang (PW) local correlation density functional [31,[49][50].…”

Section: Computational Resultsmentioning

confidence: 99%

“…Because of its bitter taste, it is often called bitter leaf in English. Some natural constituents that are found in the leaves include flavonoids (luteolin, luteolin 7-O-glucosides andluteolin 7-O-glucuronide) [24], tannins [25] and sesquiterpene lactones containing vernodalin, vernodaloland 11, 13-dihydrovernodalin [26]. The electronic structures of some of these constituents ( Figure 1) are comparable to those of regular organic corrosion inhibitors [27].Vernonia amygdalina has of course been previously investigated for corrosion inhibiting efficacy [27][28][29][30]; but not in sufficient detail to yield the mechanistic insights envisaged in the present study, accomplished via a combination of experimental and computational techniques.…”

Section: Introductionmentioning

confidence: 99%

Exploiting the Anticorrosion Effects of Vernonia Amygdalina Extract for Protection of Mild Steel in Acidic Environments

Adindu

Ogukwe

Eze

et al. 2016

Journal of Electrochemical Science and Technology

View full text Add to dashboard Cite

The corrosion protection of mild steel in 1 M HCl and 0.5 M H solutions by ethanol extract of Vernonia amygdalina (VA) was studied using a combination of experimental and computational methods. The obtained results revealed that VA reduced the corrosion of mild steel in both environments and inhibition efficiency increased with VA concentration but decreased with prolonged exposure. Electrochemical results showed that the extract functioned via mixed corrosion inhibiting mechanism by adsorption of some organic constituents of the extract on the metal/acid interface. Findings from infrared spectroscopy and electron microscopy all confirmed that VA retarded mild steel corrosion in both 1 M HCl and 0.5 M H 2 SO 4 through an adsorption process. The adsorption behavior of selected constituents of the extract was modeled using density functional theory computations.

show abstract

“…They are transformers which alter the body biochemical reactions to carcinogenic chemicals, viruses, and things that trigger allergies. Many plants display their characters for anticancer, antiinflammatory, antibacterial and anti-allergic nature [22], and could be useful in therapeutic roles [23].…”

Section: Discussionmentioning

confidence: 99%

Exploration of Novel Phytocomponents of Siddha Formulation Pungampoo Chooranam by Qualitative, Quantitative and Fluorescent analysis

Nisha¹

2017

Int. J. Adv. Multidiscip. Res.

View full text Add to dashboard Cite

The importance of medicinal plant in drug development is known to us and humans have used them for different diseases from the beginning of human history. Traditional folk treatment from wild plants has always guided researchers to search for novel medications to develop healthy life for humans and animals. In addition, some medicinal plants are still obscured within the plants which need to be scientifically evaluated. Pongamia pinnata is one such Indian traditional herb which offers numerous therapeutic benefits to mankind since several centuries. Siddha system of traditional medicine uses several valuable medicinal herbs for its formulations. Pungampoo Chooranam (PPC) is a novel siddha preparation which majorly comprises of Pongamia pinnata .The main aim of the present investigation is to carry out the qualitative, quantitative, fluorescent analysis and sterility evaluation of the formulation PPC. The result of the qualitative phytochemical analysis shows presence of alkaloids, steroids, triterpenoids, phenols, tannins, and carbohydrates. Results of quantitative analysis reveals that the total alkaloid level of the sample PPC was found to be 0.48 ± 0.05 mg/gm and the level of total tannins was 0.38 ± 0.02 mg/gm, whereas the level of Total phenols was found to be 0.78 ± 0.04 (GAE mg/gm).Further the sample is of highly sterile and free from E-coli, Salmonella, Staphylococcus aureus, Pseudomonas aeruginosa. In conclusion the results of the present investigation render some evidence based information about the siddha formulation Pungampoo Chooranam with respect to the nature and quantity of phytochemical present in it and also about the sterility and pattern of fluorescent emitting nature of the formulation PPC to the future researchers.

show abstract

Bitter steroid glucosides, vernoniosides A1, A2, and A3, and related B1 from a possible medicinal plant, Vernonia amygdalina, used by wild chimpanzees.

Cited by 138 publications

References 6 publications

Phytochemical Screening, Antifungal and Antibacterial Activity of Aqueous and Ethanolic Leaf and Stem Extracts of Gnetum africanum Welw

Phytochemical Screening, Antifungal and Antibacterial Activity of Aqueous and Ethanolic Leaf and Stem Extracts of Gnetum africanum Welw

Exploiting the Anticorrosion Effects of Vernonia Amygdalina Extract for Protection of Mild Steel in Acidic Environments

Exploration of Novel Phytocomponents of Siddha Formulation Pungampoo Chooranam by Qualitative, Quantitative and Fluorescent analysis

Contact Info

Product

Resources

About