Black currant seed oil supplementation of mothers enhances <scp>IFN</scp>‐γ and suppresses <scp>IL</scp>‐4 production in breast milk

Linnamaa, Pia; Nieminen, Kaisa; Koulu, Leena; Tuomasjukka, Saska; Kallio, Heikki; Yang, Baoru; Tahvonen, Raija; Savolainen, J.

doi:10.1111/pai.12110

Cited by 23 publications

(21 citation statements)

References 33 publications

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“…Therefore, it would be highly recommended to include a detailed nutritional assessment in further studies addressing human milk composition. On the other hand, certain foods or supplements, such as fish oil (17), black currant seed oil (80), or probiotic bacteria, more commonly used in certain population groups (79, 89–91), might modify the immunological composition of human milk. In our study, declaration of consumption of probiotic supplements and/or fermented foods by the participants significantly varied among locations, with the highest consumption rates (30%) in VHHD countries.…”

Section: Discussionmentioning

confidence: 99%

What’s Normal? Immune Profiling of Human Milk from Healthy Women Living in Different Geographical and Socioeconomic Settings

et al. 2017

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Human milk provides a very wide range of nutrients and bioactive components, including immune factors, human milk oligosaccharides, and a commensal microbiota. These factors are essential for interconnected processes including immunity programming and the development of a normal infant gastrointestinal microbiome. Newborn immune protection mostly relies on maternal immune factors provided through milk. However, studies dealing with an in-depth profiling of the different immune compounds present in human milk and with the assessment of their natural variation in healthy women from different populations are scarce. In this context, the objective of this work was the detection and quantification of a wide array of immune compounds, including innate immunity factors (IL1β, IL6, IL12, INFγ, TNFα), acquired immunity factors (IL2, IL4, IL10, IL13, IL17), chemokines (IL8, Groα, MCP1, MIP1β), growth factors [IL5, IL7, epidermal growth factor (EGF), granulocyte colony-stimulating factor, granulocyte–macrophage colony-stimulating factor, TGFβ2], and immunoglobulins (IgA, IgG, IgM), in milk produced by healthy women of different ethnicities living in different geographic, dietary, socioeconomic, and environmental settings. Among the analyzed factors, IgA, IgG, IgM, EGF, TGFβ2, IL7, IL8, Groα, and MIP1β were detected in all or most of the samples collected in each population and, therefore, this specific set of compounds might be considered as the “core” soluble immune factors in milk produced by healthy women worldwide. This approach may help define which immune factors are (or are not) common in milk produced by women living in various conditions, and to identify host, lifestyle, and environmental factors that affect the immunological composition of this complex biological fluid.Clinical Trial Registration: , identifier NCT02670278.

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Section: Discussionmentioning

confidence: 99%

What’s Normal? Immune Profiling of Human Milk from Healthy Women Living in Different Geographical and Socioeconomic Settings

et al. 2017

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“…The most frequently reported allergic outcomes were eczema, asthma, wheeze or asthma/wheeze together. Also, while there was a later publication from a study published in 2010 (31) , data were extracted from the 2010 report since the follow-up paper (30) only reported pre-clinical outcomes. Furthermore, the register-based outcomes in the study by Hansen 2016 were considered in this review.…”

Section: Reported Allergic Outcomes and Follow-up Durationmentioning

confidence: 99%

ω-3 LCPUFA supplementation during pregnancy and risk of allergic outcomes or sensitization in offspring

Vahdaninia

MacKenzie

Dean

et al. 2019

Annals of Allergy, Asthma & Immunology

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Background: Allergic diseases have seen a rise worldwide in the last two decades, with children suffering the highest burden of the condition. The ω-3 Long-Chain Poly-Unsaturated fatty Acid (LCPUFA) poses anti-inflammatory properties that could lead to a reduction in inflammatory mediators in allergies. Objective: A systematic review and meta-analysis of the most recent follow-ups of randomised controlled trials (RCTs) was conducted to assess the effectiveness of ω-3 LCPUFA supplementation started during pregnancy on allergic outcomes in offspring. Methods: RCTs with a minimum of 1-month follow-up post gestation were eligible for inclusion. The CENTRAL, MEDLINE, SCOPUS, WHO's International Clinical Trials Register, E-theses and Web of Science databases were searched. Study quality was evaluated using the Cochrane Collaboration's risk of bias tool. Results: Ten RCTs (3,637 children), from nine unique trials examined the effectiveness of ω-3 LCPUFA supplementation started during pregnancy on the development of allergic outcomes in offspring. There were heterogeneities between the trials in terms of their sample, type and duration of intervention and follow-up. Pooled estimates showed a significant reduction in childhood "sensitisation to egg" (Relative Risk (RR)=0.54, 95% Confidence Interval (CI)=0.32-0.90) and "sensitisation to peanut" (RR=0.62, 95% CI=0.40-0.96). No statistical differences were found for other allergic outcomes e.g. any allergies, eczema, asthma/wheeze. Conclusion: These results suggest intake of ω-3 LCPUFA started during pregnancy can reduce the risk of sensitisation to egg and peanut; however the evidence is limited due to the small number of studies contributed to meta-analyses. The current evidence on the association between supplementation with ω-3 LCPUFA started during pregnancy and allergic outcomes is weak due to the risk of bias and heterogeneities between studies.

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“…Blackcurrant production in Poland is approximately 200,000 tons/year (Polish Central Statistical Office (2014), and seeds constitute 15% to 30% of the weight (Hilz et al 2005). Blackcurrant seeds are subjected to supercritical CO2 extraction for the production of oils used in pharmaceutical or cosmetic industries (Danaher et al 2011;Costa et al 2013;Linnamaa et al 2013). Extracted oils have anti-oxidative properties and therefore could be used as functional foods or food supplements.…”

Section: Introductionmentioning

confidence: 99%

“…One of the methods of management of these residues is use as a fertilizer biocomponent. Blackcurrant seeds contain a large number of lignans and cutin polymers with hydroxyl and epoxy groups (Hilz et al 2005;Linnamaa et al 2013). They are also the source of all essential amino acids and good grade quality proteins.…”

Section: Introductionmentioning

confidence: 99%

Pilot Plant Conversion of Blackcurrant Seeds into New Micronutrient Fertilizer Biocomponents via Biosorption

et al. 2015

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A new approach for micronutrient fertilizer biocomponent production based on blackcurrant seeds is presented. Blackcurrant seeds constitute a by-product from the production of jellies, jams, and juices. New environmental-friendly fertilizers with micronutrients were produced in the pilot plant as alternative sustainable fertilizers to conventional options. Post-extraction residues, obtained after supercritical CO2 extraction was conducted on blackcurrant seeds, were used. In each process, 15 kg of biosorbent was used. Good sorption capacity was achieved (6.48 mg/g for Zn(II), 13.9 mg/g for Cu(II) and 5.88 mg/g for Mn (II)). The adsorption kinetics was described using different kinetic models; the most suitable were the Nelson-Yoon and Thomas models. The new preparation has application-friendly form (micro-granules) and is nontoxic. For a dose of 2.5 kg of zinc, 1 kg of manganese, and 0.5 kg of copper per hectare (often used in vegetable fertilization), approximately 600 kg of mixed end product is required. The cost of fertilization with current scale technology will be about four times higher than that of conventional technology (including depreciation of equipment), but with process scale-up, it is possible to reduce costs even twice over.

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Black currant seed oil supplementation of mothers enhances IFN‐γ and suppresses IL‐4 production in breast milk

Abstract: Dietary intervention with BCSO had immunomodulatory effects on breast milk cytokine production towards Th2 to Th1 immunodeviation.

Cited by 23 publications

References 33 publications

What’s Normal? Immune Profiling of Human Milk from Healthy Women Living in Different Geographical and Socioeconomic Settings

What’s Normal? Immune Profiling of Human Milk from Healthy Women Living in Different Geographical and Socioeconomic Settings

ω-3 LCPUFA supplementation during pregnancy and risk of allergic outcomes or sensitization in offspring

Pilot Plant Conversion of Blackcurrant Seeds into New Micronutrient Fertilizer Biocomponents via Biosorption

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