Black garlic melanoidins prevent obesity, reduce serum LPS levels and modulate the gut microbiota composition in high-fat diet-induced obese C57BL/6J mice

Wu, Jianfu; Liu, Yanan; Dou, Zishan; Wu, Tao; Li, Rui; Sui, Wenjie; Jin, Yan; Zhang, Min

doi:10.1039/d0fo02379e

Cited by 41 publications

(31 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 79 . On the other hand, short chain fatty acids (SCFAs) derived from gut microbiota are involved in the pathogenesis of NASH, SCFA‐producing bacteria, such as S24‐7 80 and Bacteroidaceae , 81 could play beneficial roles in stimulating the immune response and protecting the mucosal barrier in mice. Our results indicated that VVYP treatment could restore gut microbiota by strongly enhancing the abundance of secondary BA‐producing bacteria ( Coriobacteriacease and Desulfovibrionaceae ) and SCFA‐producing bacteria ( S24‐7 and Bacteroidia ).…”

Section: Discussionmentioning

confidence: 99%

“…Coriobacteriaceae, certain species of which have been proved to be beneficial to host lipid metabolism, 78 were increased after butyrate treatment. 25 It is well known that another important factor contributing to changes in the liver expression of genes is the interplay between gut microbiota and bile acid (BA) metabolism, protective gut microbiota(Desulfovibrionaceae and Coriobacteriaceae) associates with increased specific secondary BAs, which likely inhibit lipogenic pathways and enhance bile flow in the liver.. 79 On the other hand, short chain fatty acids (SCFAs) derived from gut microbiota are involved in the pathogenesis of NASH, SCFA-producing bacteria, such as S24-7 80 and Bacteroidaceae, 81 Previous studies demonstrated that another crucial participator in the progression of NASH is the network of pro-inflammatory chemokines and cytokines. 82,83 Several inflammatory factors, such as TNF-α, IL-1β and IL-6, have been proved to enable steatosis and liver damage, thus promoting the occurrence and progression of NASH.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Val‐Val‐Tyr‐Pro protects against non‐alcoholic steatohepatitis in mice by modulating the gut microbiota and gut‐liver axis activation

Xie

Zhang

Yuan

et al. 2021

J Cellular Molecular Medi

View full text Add to dashboard Cite

Val‐Val‐Tyr‐Pro (VVYP) peptide is one of the main active components of Globin digest (GD). Our previous studies indicated that VVYP could protect against acetaminophen and carbon tetrachloride‐induced acute liver failure in mice and decrease blood lipid level. However, the effects and underlying mechanisms of VVYP in the treatment of non‐alcoholic steatohepatitis (NASH) have not been discovered. Our present study was designed to investigate the preventive effect of VVYP on NASH and its underlying specific mechanisms. We found that VVYP inhibited the cytotoxicity and lipid accumulation in L‐02 cells that were exposed to a mixture of free fatty acid (FFA). VVYP effectively alleviated the liver injury induced by methionine‐choline‐deficient (MCD) diet, demonstrated by reducing the levels of serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST)/triglycerides (TG)/non‐esterified fatty acids (NEFA) and improving liver histology. VVYP decreased expression levels of lipid synthesis‐related genes and reduced levels of the proinflammation cytokines in the liver of mice fed by MCD diet. Moreover, VVYP inhibited the increased level of LPS and reversed the liver mitochondria dysfunction induced by MCD diet. Meanwhile, VVYP significantly increased the abundance of beneficial bacteria such as Eubacteriaceae , coriobacteriacease, Desulfovibrionaceae, S24‐7 and Bacteroidia in high‐fat diet (HFD)‐fed mice, however, VVYP reduced the abundance of Lactobacillus . Moreover, VVYP conferred the protective effect of intestinal barrier via promoting the expression of the mucins and tight junction (TJ)‐associated genes and inhibited subsequent liver inflammatory responses. These results indicated that the protective role of VVYP on NASH is mediated by modulating gut microbiota imbalance and related gut‐liver axis activation. VVYP might be a promising drug candidate for NASH.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Val‐Val‐Tyr‐Pro protects against non‐alcoholic steatohepatitis in mice by modulating the gut microbiota and gut‐liver axis activation

Xie

Zhang

Yuan

et al. 2021

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…When the number of harmful intestinal microbes is increased, their metabolites will lead to changes in the intestinal structure and permeability. Increased permeability also increased the number of microbes, the endotoxin or lipopolysaccharide ( LPS ) ( Wu et al., 2020 ), and harmful metabolites entering the intestine, causing systemic immune response, inflammation, and changes in the function of other organs and tissues ( Luci et al., 2019 ). There is a certain relationship between intestinal physiology and microorganisms and fatty liver formation induced by sugar ( Li et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

“…Glucose metabolism pathway disorder induces liver fatty degeneration and intestinal mucosal barrier dysfunction in metabolism-associated fatty liver disease ( MAFLD ) ( Gao et al., 2020 ; Wang et al., 2020 ). Wu et al. (2020) reported that gut microbiota modulation can improve glucose tolerance, induce the production of Short Chain Fatty Acids and inhibit the production of endotoxin LPS.…”

Section: Introductionmentioning

confidence: 99%

Effect of different types of sugar on gut physiology and microbiota in overfed goose

Wei

Deng

et al. 2021

Poultry Science

View full text Add to dashboard Cite

To explored the difference of goose fatty liver formation induced-by different types of sugar from the intestinal physiology and the gut microflora, an integrated analysis of intestinal physiology and gut microbiota metagenomes was performed using samples collected from the geese including the normal-feeding geese and the overfed geese which were overfed with maize flour or overfeeding dietary supplementation with 10% sugar (glucose, fructose or sucrose, respectively), respectively. The results showed that the foie gras weight of the fructose group and the sucrose group was heavier ( P < 0.05) than other groups. Compared with the control group, the ileum weight was significantly higher ( P < 0.01), and the cecum weight was significantly lower in the sugar treatment groups ( P < 0.001). Compared with the control group, the ratio of villi height to crypt depth in the fructose group was the highest in jejunum ( P < 0.05); the trypsin activity of the ileum was higher in the fructose group and the sucrose group ( P < 0.05). At the phylum level, Firmicutes, Proteobacteria and Bacteroidetes were the main intestinal flora of geese; and the abundance of Firmicutes in the jejunum was higher in the sugar treatment groups than that of the maize flour group. At the genus level, the abundance of Lactobacillus in the jejunum was higher ( P < 0.05) in the sugar treatment groups than that of the maize flour group. In conclusion, forced-feeding diet supplementation with sugar induced stronger digestion and absorption capacity, increased the abundance of Firmicutes and Bacteroidetes and the abundance of Lactobacillus (especially fructose and sucrose) in the gut. So, the fructose and sucrose had higher induction on hepatic steatosis in goose fatty liver formation.

show abstract

“…16 A variety of biological activities of melanoidin has been demonstrated, including antioxidant, antibacterial, anti-in ammatory, hypoglycemic, hypotensive, antitumor effects, prevention of obesity, lowering of serum lipopolysaccharide levels, and modulation of the composition of the gut microbiota. 16,17 Additionally, inhibition against oxidation and angiotensin I converting enzyme were enhanced in black garlic comparing to raw garlic. 15 Therefore, the heating and ageing process not only preserved the food but also enhanced their biological activities.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Phenolics Content and Biological Activities of Longan (Dimocarpus Longan Lour.) Treated with Thermal and Aging Process

Hong-in

Neimkhum

Punyoyai

et al. 2021

Preprint

View full text Add to dashboard Cite

This study is the first to successfully produce novel black Dimocarpus longan by undergoing thermal and ageing process. Pericarp, aril, and seed of black D. longan were macerated in 95% v/v ethanol. Their chemical compositions were investigated by Folin–Ciocalteu assay, aluminium chloride assay, and high-performance liquid chromatography. Antioxidant activities were evaluated in terms of radical scavenging and iron (III) reducing capacity. Enzyme inhibitory assay was used to evaluate the hyaluronidase inhibition. Black D. longan seed extract contained the significantly highest content of flavonoids and phenolic compounds (p < 0.05). Each gram of the extract contained 53.6 ± 0.9 mg of gallic acid, 19.8 ± 2.9 mg of corilagin, and 24.5 ± 0.7 mg of ellagic acid. This extract was the most potent anti-hyaluronidase and antioxidant with the strongest free radical scavenging activity and reducing power. Therefore, it was proposed as functional food and further used in the pharmaceutical or cosmeceutical industries.

show abstract

Black garlic melanoidins prevent obesity, reduce serum LPS levels and modulate the gut microbiota composition in high-fat diet-induced obese C57BL/6J mice

Abstract: The objective of this study was to assess the potential anti-obesity effects of black garlic melanoidins (MLDs) and gut microbiota changes in an animal model, hypothesizing that oral administration of...

Cited by 41 publications

References 36 publications

Val‐Val‐Tyr‐Pro protects against non‐alcoholic steatohepatitis in mice by modulating the gut microbiota and gut‐liver axis activation

Val‐Val‐Tyr‐Pro protects against non‐alcoholic steatohepatitis in mice by modulating the gut microbiota and gut‐liver axis activation

Effect of different types of sugar on gut physiology and microbiota in overfed goose

Enhancement of Phenolics Content and Biological Activities of Longan (Dimocarpus Longan Lour.) Treated with Thermal and Aging Process

Contact Info

Product

Resources

About