The objective of this study was to assess the potential anti-obesity effects of black garlic melanoidins (MLDs) and gut microbiota changes in an animal model, hypothesizing that oral administration of...
The
purpose of this study is to explore the effects of different
molecular weight black garlic melanoidins (MLDs) on high fat diet
(HFD) induced dysrhythmia of intestinal microorganisms. The results
showed that a HFD disturbed the periodic fluctuation of the gut microbiome
and that oral gavage of low molecular weight melanoidin (LMM) or high
molecular weight melanoidin (HMM) reversed these cyclical variations
in part, which resulted in an increase in the number of bacteria producing
short-chain fatty acids (SCFAs) and a decrease in the oscillation
of inflammation-related bacteria within a specific time period over
the course of 1 day. Moreover, structural analysis showed different
structure characterizations of LMM and HMM, which are related to the
differences in flora oscillation. Therefore, the data showed that
LMM and HMM relieve the circadian rhythm disorder of intestinal microbiota
induced by a HFD in mice, which supported the further study of MLDs
as a new dietary assistant strategy to improve chronic diseases.
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