Bladder Cancer as a Prognostic Factor for Upper Tract Transitional Cell Carcinoma

Mullerad, Michael; Russo, Paul; Golijanin, Dragan; Chen, Hui N.I.; Tsai, Harold; Donat, S. Machele; Bochner, Bernard H.; Herr, Harry W.; Sheinfeld, Joel; Sogani, Pramod C.; Kattan, Michael W.; Dalbagni, Guido

doi:10.1097/01.ju.0000144505.40915.98

Cited by 90 publications

(59 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…5,8,[10][11][12][13][15][16][17]20,22,24,25 Regarding pT3 pelvic cancer, our data demonstrating significantly poorer outcome of patients with UCs showing macroscopic parenchyma and/or fat invasion compared with patients with UCs showing microscopic parenchyma invasion only are in line with two previous studies. 35,36 They reported that pT3 UCs with extensive parenchymal invasion (defined as invasion deeper than 5 mm) had a prognosis similar to that of pT4 tumors, whereas pT3 UCs without extensive parenchymal invasion (including cases with intraductal spread only) had a prognosis similar to that of pT1/pT2 disease.…”

Section: Discussionsupporting

confidence: 88%

“…2,8,11,12,[14][15][16][17][18][20][21][22][23][24][25]29,[32][33][34] Thus, the identification of independent prognostic variables is an essential step to predict disease evolution, thus aiding surveillance strategies, and also to identify patient subgroups that might benefit from adjuvant cancer therapy. Our study is by far the largest systematic investigation of the impact of pT classification, tumor grade, as well as vascular invasion in patients with both pelvic and ureteral UCs with respect to metastasis-free survival.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

pT classification, grade, and vascular invasion as prognostic indicators in urothelial carcinoma of the upper urinary tract

et al. 2006

View full text Add to dashboard Cite

Clinicopathologic features predictive of patient outcome in upper urinary tract urothelial carcinoma are not well defined. The aim of this study was to assess the role of pT classification, tumor grade, and vascular invasion in predicting metastasis-free survival. A total of 190 consecutive invasive upper urinary tract urothelial cancers operated between 01/1984 and 12/2004 were re-evaluated with respect to pT classification, tumor grade (according to the three-tiered WHO 1973 and the recent two-tiered grading system following the WHO/ISUP consensus classification), as well as presence of lymph and/or blood vessel invasion. Prognostic impact was analyzed using the Kaplan-Meier method and the Log-Rank test. For multivariate testing, a Cox's proportional hazards regression model was used. pT1 was present in 81 (43%), pT2 in 29 (15%), pT3 in 73 (38%), and pT4 in seven (4%) cases. There were 12 (6%) G1, 96 (51%) G2, and 82 (43%) G3 tumors or 84 (44%) low-grade and 106 (56%) high-grade tumors according to the two-tiered system. The presence of vascular invasion in 72/190 (38%) tumors was associated with high pT classification (Po0.001) and high tumor grade (Po0.001). Disease progression occurred in 39% of patients, with 5-and 10-year metastasis-free survival rates of 56 and 45%, respectively. On univariate analysis, all investigated parameters showed prognostic significance. The negative influence of vascular invasion on patient outcome was strikingly strong in high pT classification and high-grade cancers. On multivariate analysis, pT classification (Po0.001) and vascular invasion (Po0.001) proved to be independent prognostic factors, whereas tumor grade according to the two-tiered system missed statistical significance (P ¼ 0.06). In conclusion, pT classification and vascular invasion are independent prognostic factors with respect to metastasis-free survival and should be used to guide adjuvant therapy strategies in affected patients. Presence (or absence) of vascular invasion should be commented upon separately in the pathology report. Modern Pathology (2006Pathology ( ) 19, 272-279. doi:10.1038 Keywords: urothelial carcinoma; upper urinary tract; tumor classification; tumor grade; vascular invasion; prognosis A significant proportion of patients with upper urinary tract urothelial carcinoma (UC) eventually die of the disease due to unrecognized and untreated nodal or distant metastasis present at the time of surgery, indicating the importance of adequate adjuvant therapy strategies for patients at high risk of failure. Initial tumor stage and tumor grade have been documented as major prognostic factors. 1-25 However, validity of most studies is limited due to inclusion of noninvasive (pTa) cancer cases and/or small sample size. Thus, to the best of our knowledge, there are only two systematic studies involving more than 100 invasive cancer cases including both univariate and multivariate statistical analyses with respect to recurrence-free and disease-specific survival. 12,24 Moreover, the assessment of tumor gr...

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

pT classification, grade, and vascular invasion as prognostic indicators in urothelial carcinoma of the upper urinary tract

et al. 2006

View full text Add to dashboard Cite

show abstract

“…18 Our analysis failed to prove the independent prognostic role of histologic grade, which also happened in other large series. 4,[8][9][10] This may have been caused by the lack of a significant difference in survival between patients with grade 1 tumors and grade 2 tumors and by the lack of significant reproducibility in the diagnosis of grade in TCC.…”

Section: Discussionmentioning

confidence: 99%

“…3 The knowledge of prognostic factors for UUT-TCC often is based on studies on the most common bladder TCC, and only a few studies on prognostic factors for UUT-TCC have been published to date, and those sometimes have reported conflicting data. Tumor stage [4][5][6][7][8][9][10][11] and histologic grade 7,11,12 are among the best established prognostic factors; whereas, conversely, the roles of other potentially relevant variables, such as a history of bladder cancer, tumor site, lymphovascular invasion, or multifocality, are less clear. [6][7][8]10,11 A clear knowledge of those prognostic data would be useful for counseling patients after surgery and for identifying those patients with unfavorable cancer-related outcome who may be candidates for future neoadjuvant or adjuvant randomized controlled trials.…”

mentioning

confidence: 99%

Independent predictors of cancer‐specific survival in transitional cell carcinoma of the upper urinary tract

Novara

Marco

Gottardo

et al. 2007

Cancer

175

View full text Add to dashboard Cite

Sulfonation degree determination of sulfonated polystyrene and the corresponding ionomers are performed by adiabatic bomb calorimeter. The theoretical calculations from the band energies for the combustion enthalpy values (calorific values) and the experimental values are compared, and a linear relation between the values is found. Sulfonation and neutralization processes are examined by elemental sulfur analysis and atomic absorption spectroscopy (AAS). It was obvious that increasing sulfonation degree yields a decrease in the combustion enthalpy values, as it is expected from the theoretical calculations. In addition, metal ion incorporation to the structure deviates the experimental combustion enthalpy values especially for the ionomers which have higher sulfonation degrees. This is due to the formation of a higher degree aggregation. © Wiley Periodicals, Inc. J Appl Polym Sci 100: 4684–4688, 2006

show abstract

“…Mullerad et al 13 informaron de una serie de 129 pacientes y concluyeron que los antecedentes de cá ncer de vejiga tenían un efecto adverso en el pronó stico de los pacientes con TUAUS. Lee et al 14 e Inman et al 15 evaluaron a 112 y 168 pacientes, respectivamente, y hallaron que la supervivencia estaba relacionada tanto con el estadio como con el grado del tumor.…”

Section: Comentariounclassified

Carcinoma urotelial de tracto urinario superior: 114 casos con largo seguimiento

Izquierdo

Truan

Álvarez-Vijande

et al. 2010

Actas Urológicas Españolas

View full text Add to dashboard Cite

informació n del artí culo Resultados: La distribució n por estadio y grado de los tumores fue: 15 pTa, 25 pT1, 26 pT2, 32 pT3, 16 pT4, 10 (9%) G1, 52 (45,5%) G2 y 52 (45,5%) G3, respectivamente. Quince pacientes tenían afectació n adenopá tica en el momento del diagnó stico. El 14% de los 114 pacientes recibieron tratamiento adyuvante con quimioterapia (ré gimen basado en platino).Tras un seguimiento medio de 74,8 meses, el 30,7% de los pacientes presentaron progresió n tumoral y el 24,6% mortalidad específica por cá ncer. La supervivencia global y la cá ncer específica a los 5 añ os fue del 59,3% y 72,9%, respectivamente. La supervivencia libre de enfermedad a los 5 añ os fue del 68%. Los tiempos medios hasta la progresió n tumoral y hasta la muerte específica por cá ncer fueron de 12,2 y 23,2meses, respectivamente. El aná lisis multivariable mostró como factores independientes de progresió n tumoral y mortalidad específica por cá ncer el grado histoló gico y el estadio patoló gico.

show abstract

Bladder Cancer as a Prognostic Factor for Upper Tract Transitional Cell Carcinoma

Abstract: This study demonstrates that a history of BTCC (invasive or superficial) has an adverse effect on the prognosis of patients diagnosed with UTTCC independent of primary tumor stage.

Cited by 90 publications

References 14 publications

pT classification, grade, and vascular invasion as prognostic indicators in urothelial carcinoma of the upper urinary tract

pT classification, grade, and vascular invasion as prognostic indicators in urothelial carcinoma of the upper urinary tract

Independent predictors of cancer‐specific survival in transitional cell carcinoma of the upper urinary tract

Carcinoma urotelial de tracto urinario superior: 114 casos con largo seguimiento

Contact Info

Product

Resources

About