Bletilla striata: Medicinal uses, phytochemistry and pharmacological activities

He, Xirui; Wang, Xiaoxiao; Fang, Jugao; Zhao, Zhengyan; Huang, Libei; Guo, Hao; Zheng, Xiaohao

doi:10.1016/j.jep.2016.11.026

Cited by 243 publications

(131 citation statements)

References 59 publications

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“…It is sweet, and slightly cold with prominent effects of healing muscles and stopping bleeding. Hence is ideal for treating traumatic bleeding [1] . At present, due to the limitation of the traditional artificial breeding methods, the production of B. striata tuber and its medicinal active ingredients is difficult to meet the market demand [2] .…”

Section: Introductionmentioning

confidence: 99%

Cell growth kinetics and accumulation of secondary metabolite of Bletilla striata Rchb.f. using cell suspension culture

Pan

Xiao

et al. 2019

Preprint

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14 15 [Abstract] Bletilla striata (Orchidaceae) is a well-recognized endangered medicinal 16 plant due to inadequate natural reproduction with high market worth. To evaluate the 17 cell growth kinetics and accumulation of secondary metabolites (SMs), the cell 18 suspension culture is proved to be a valuable approach for acquiring the high yield of 19 medicinal parts. An effective cell suspension culture for obtaining B. striata cell 20 growth and its SMs was in vitro induction of callus from B. striata seeds. The cell 21 growth kinetics and accumulation of SMs were analyzed using the mathematical 22 model. Results cell growth kinetic model revealed that the growth curve of B. striata 23 suspension cells was curved as sigmoid shape, indicating the changes of the growth 24 curve of suspension cells. Improved Murashige and Skoog cell growth medium was 25 the utmost favorable medium for B. striata callus formation with the highest cell 26 growth during the stationary phase of cultivation period, the cell growth acceleration 27was started after 7 days and thereafter gradually decrease at 24 day and then reached 28 to highest at 36 day of cultivation period in both dry weight and fresh weight. The 29 coelonin concentration was peak during exponential growth stage and decreased 30 afterward at the stationary phase in the cell suspension culture. The maximum content 31 of coelonin (about 0.3323 mg/g cell dry weight) was observed on the 18th day of the 32 cultivation cycle while the dactylorhin A and militarine reached highest at 24 day, and 33 p-hydroxybenzyl alcohol at 39 day. This investigation also laid a foundation for 34 multi-mathematical model to better describe the accumulation variation of SMs. The 35 production of SMs had shown great specificity during cells growth and development. 36 This research provided a well-organized way to more accumulation and production of 37 SMs, on scale-up biosynthesis in B. striata cell suspension culture. 38[Key words] Bletilla striata; suspension culture; growth curve; secondary 39 metabolites; kinetics; mathematical model 40 41 Introduction 42Bletilla striata is a perennial herb of Orchidaceae, which is an important traditional 43 Chinese herbal medicine recorded in the pharmacopoeia of all previous dynasties. It is 44 sweet, and slightly cold with prominent effects of healing muscles and stopping 45 bleeding. Hence is ideal for treating traumatic bleeding [1] . At present, due to the 46 limitation of the traditional artificial breeding methods, the production of B. striata 47 tuber and its medicinal active ingredients is difficult to meet the market demand [2] . B. 48 striata has turn out to be an endangered class with the falling down wild plant 49 properties due to over utilization in current periods. For the sustainable progress and 50 comprehensive consumption of B. striata, it is essential to recognize its cell growth 51 dynamics with the accumulation of SMs. However, until now, limited approaches 52 have been developed on these perspectives. In addition, the quali...

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Section: Introductionmentioning

confidence: 99%

Cell growth kinetics and accumulation of secondary metabolite of Bletilla striata Rchb.f. using cell suspension culture

Pan

Xiao

et al. 2019

Preprint

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“…Bletilla striata is commonly used as a herbal medicine in eastern Asian countries (mainly in mainland China and Japan). Its tuber has been widely used to treat bleeding, colds, esophagitis, erosive gastritis, and burns for thousands of years . The Chinese Pharmacopoeia states that B. striata possesses the functions of hemostasia, detumescence, healing and enhancement of bodily function .…”

Section: Introductionmentioning

confidence: 99%

“…Its tuber has been widely used to treat bleeding, colds, esophagitis, erosive gastritis, and burns for thousands of years. 4 The Chinese Pharmacopoeia states that B. striata possesses the functions of hemostasia, detumescence, healing and enhancement of bodily function. 5 Modern research shows that it is also known to be involved in antioxidant and antitumor activities.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies revealed that B. striata mainly contained compounds such as bibenzyls, dihydrophenanthrenes, biphenanthrenes, phenanthrenes, triterpenoids and its saponin, steroids and its saponins, cyanidin glycosides, phenanthraquinones, anthraquinones, lignans, organic acids, glucosyloxybenzyl 2-isobutylmalates, polysaccharides, and so on 7,8 So far, most of the studies have suggested that bibenzyls, dihydrophenanthrenes, biphenanthrenes, and polysaccharides were the main active substances. 4,9 Figure 1 shows the chemical skeleton structures of bibenzyls, dihydrophenanthrenes, and biphenanthrenes. One or more of these compounds can be used as a classification and quality evaluation of B. striata.…”

Section: Introductionmentioning

confidence: 99%

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Quality evaluation and traceability of Bletilla striata by fluorescence fingerprint coupled with multiway chemometrics analysis

Yin

et al. 2018

J Sci Food Agric

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“…Reichb. f. (Orchidaceae) known as Hyacinth Orchid, Common Bletilla Tuber, Japanorchidee (German), Shiran (Japanese), Jaran (Korean), and Baiji (baiji) is not only an ornamental garden in Europe and United States but an important astringent hemostatic medicinal plant native to East Asia [7, 8]. Traditional Chinese Medicine (TCM) holds that it is capable of restraining leakage of blood and stopping bleeding, dispersing swelling, and promoting tissue regeneration [9].…”

Section: Introductionmentioning

confidence: 99%

Bletilla striata Micron Particles Function as a Hemostatic Agent by Promoting Rapid Blood Aggregation

Zhang

Zeng

Liao

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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The human body cannot control blood loss without treatment. Available hemostatic agents are ineffective at treating cases of severe bleeding and are expensive or raise safety concerns. Bletilla striata serve as an inexpensive, natural, and promising alternative. However, no detailed studies on its hemostatic approach have been performed. The aim of this study was to examine the hemostatic effects of B. striata Micron Particles (BSMPs) and their hemostatic mechanisms. We prepared and characterized BSMPs of different size ranges and investigated their use as hemostatic agent. BSMPs of different size ranges were characterized by scanning electron microscope. In vitro coagulation studies revealed BSMP-blood aggregate formation via stereoscope and texture analyzers. In vivo studies based on rat injury model illustrated the BSMP capabilities under conditions of hemostasis. Compared to other BSMPs of different size ranges, BSMPs of 350–250 μm are most efficient in hemostasis. As powder sizes decrease, the degree of aggregation between particles and hemostatic BSMP effects declines. The BSMP in contact with a bleeding surface locally forms a visible particle/blood aggregate as a physical barrier that facilitates hemostasis. Considering the facile preparation, low cost, and long shelf life of B. striata, BSMPs offer great potential as mechanisms of trauma treatment.

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Bletilla striata: Medicinal uses, phytochemistry and pharmacological activities

Cited by 243 publications

References 59 publications

Cell growth kinetics and accumulation of secondary metabolite of Bletilla striata Rchb.f. using cell suspension culture

Cell growth kinetics and accumulation of secondary metabolite of Bletilla striata Rchb.f. using cell suspension culture

Quality evaluation and traceability of Bletilla striata by fluorescence fingerprint coupled with multiway chemometrics analysis

Bletilla striata Micron Particles Function as a Hemostatic Agent by Promoting Rapid Blood Aggregation

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