Blocking of impulse conduction in peripheral nerves by local cooling as a routine in animal experimentation

Patberg, Wiebe R.; Melchior, Hj; Mast, J

doi:10.1016/0165-0270(84)90019-0

Cited by 7 publications

(4 citation statements)

References 10 publications

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“…Nerve cooling and electrical nerve blocking both have the advantage of being “on-demand” nerve blocking techniques which are fast acting and quickly reversible (tens of milliseconds to tens of seconds depending on the technique) (Bhadra and Kilgore, 2004; Kilgore and Bhadra, 2004; Patberg et al, 1984). Nerve cooling has the additional advantage of inducing conduction block without first inducing a transient activation of the nerve (Patberg et al, 1984).…”

Section: Introductionmentioning

confidence: 99%

“…Nerve cooling has the additional advantage of inducing conduction block without first inducing a transient activation of the nerve (Patberg et al, 1984). This technique has been proven to be effective in both acute (Franz and Iggo, 1968; Patberg et al, 1984) and chronic preparations (Borgdorff and Versteeg, 1984) for inducing intermittent blockade of neural activity for short periods of time. However, delivery of nerve cooling for periods longer than a few tens of seconds is made difficult by the need to exhaust the heat that is necessarily induced as a by-product of the cooling.…”

Section: Introductionmentioning

confidence: 99%

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Nerve conduction block using combined thermoelectric cooling and high frequency electrical stimulation

Ackermann

Foldes

Bhadra

et al. 2010

Journal of Neuroscience Methods

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Conduction block of peripheral nerves is an important technique for many basic and applied neurophysiology studies. To date, there has not been a technique which provides a quickly initiated and reversible “on-demand” conduction block which is both sustainable for long periods of time and does not generate activity in the nerve at the onset of the conduction block. In this study we evaluated the feasibility of a combined method of nerve block which utilizes two well established nerve blocking techniques in a rat and cat model: nerve cooling and electrical block using high frequency alternating currents (HFAC). This combined method effectively makes use of the contrasting features of both nerve cooling and electrical block using HFAC. The conduction block was initiated using nerve cooling, a technique which does not produce nerve “onset response” firing, a prohibitive drawback of HFAC electrical block. The conduction block was then readily transitioned into an electrical block. A long-term electrical block is likely preferential to a long-term nerve cooling block because nerve cooling block generates large amounts of exhaust heat, does not allow for fiber diameter selectivity and is known to be unsafe for prolonged delivery.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nerve conduction block using combined thermoelectric cooling and high frequency electrical stimulation

Ackermann

Foldes

Bhadra

et al. 2010

Journal of Neuroscience Methods

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“…The tonic activity of the diaphragm could be increased further by both lung inflation [2,10] and deflation [10]. The influence of local vagus cooling on conduction in myelinated (A) and non-myelinated (C) vagal fibres has been studied in the cat 11,7] and the dog [4,5]. In general, the blocking temperature of the vagal A fibres was 7-8 ~ conduction in vagal C fibres was blocked between 4.6 and 0.3 ~ We considered the above-mentioned effect on the diaphragm after bilateral local vagus cooling to 8 ~ to be the result of afferent C fibre impulses.…”

Section: Introductionmentioning

confidence: 99%

“…The vagus nerve was exposed in the neck over a length of about 5 cm and transsected about I cm distal from the nodose gan~ion. The peripheral tnmk was placed in the nerve groove (12 mm long, 0.8 mm wide) of a cooling thermode as described previously (11). Pairs of silver stimulating and recording electrodes were placed caudally and cranially to the thermode, respectively.…”

Section: Introductionmentioning

confidence: 99%

Effects of local nerve cooling on conduction in vagal fibres shed light upon respiratory reflexes in the rabbit

et al. 1992

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In ten vagus nerves the effect of local cooling on the compound action potential was studied in the temperature range of 34 to 0 degrees C in spontaneously breathing, anaesthetized rabbits. The mean temperature at which the myelinated (A) fibres were completely blocked, was 10.2 +/- 2.4 degrees C (mean +/- S.D.). In nine nerves, local vagus cooling to 0 degrees C failed to block all non-myelinated (C) fibres. In one nerve, total blocking occurred at 2.0 degrees C. We conclude that in the rabbit, the earlier found increase in tonic activity of the diaphragm following lung inflation or deflation during bilateral local vagus cooling to a temperature between 8 and 0 degrees C is due to afferent impulses in vagal C fibres.

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Reflex apnea induced by high-frequency oscillatory ventilation in rabbits

Kohl

Freund

Koller

1991

Respiration Physiology

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Blocking of impulse conduction in peripheral nerves by local cooling as a routine in animal experimentation

Cited by 7 publications

References 10 publications

Nerve conduction block using combined thermoelectric cooling and high frequency electrical stimulation

Nerve conduction block using combined thermoelectric cooling and high frequency electrical stimulation

Effects of local nerve cooling on conduction in vagal fibres shed light upon respiratory reflexes in the rabbit

Reflex apnea induced by high-frequency oscillatory ventilation in rabbits

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