Blood and Bone Marrow Follow-Up Studies on Patients with Preleukemic States — Observation of Different Phases of the Evolving Leukemic Process

After a single pulse dose of DMBA, rats develop bone-marrow hypoplasia, which is almost compensated for by regeneration after 16 weeks. Subsequently, dysplastic signs of hemopoiesis appear in all experimental animals as massive extrusion of normoblasts into the peripheral blood, red-cell aniso- and poikilocytosis, nuclear deformities, atypical mitoses, and PAS-positivity, as well as megaloblastoid maturation dissociation of erythroblasts and nuclear and granulation anomalies of neutrophilic granulocytes and monocytes, comparable to human "pseudo-Pelger cells" and "paraneutrophils". At the time of death (112-497 days after DMBA pulse) experimental animals showed hyperplastic bone marrow with increased granulopoietic/erythropoietic ratios and an augmented, mainly erythropoietic, hemopoiesis in the spleen, with splenomegaly in six rats. Splenic hemopoiesis is accompanied by white pulp atrophia. The cause of death was septicopyemia in three rats, anemia in three, and bleeding in one rat. None of the animals developed a leukemic blast phase. Myelodysplastic changes in this experiment are the same as have been shown to precede leukemia in rats treated with five DMBA pulses (Fohlmeister et al. 1981). Possible relations of myelodysplasia and leukemia are discussed.

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Bone marrow mast cell reaction in preleukaemic myelodysplasia and in aplastic anaemia

Fohlmeister

Reber

Fischer

1985

Vichows Archiv A Pathol Anat

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The relationship of bone marrow mast cell counts to prognosis was investigated in 48 patients with preleukaemic myelodysplasia, in 59 patients with aplastic anemia and in a DMBA induced myelodysplasia/leukaemia rat model. In patients with myelodysplasia terminating in overt leukaemia the number of mast cells per square millimeter was not correlated to duration of the preleukaemic course. Leukaemia development probabilities of patients at risk were not different for low and elevated mast cell counts. In aplastic anaemia, however, a lower bone marrow mast cell count was related to a higher survival probability and longer survival time. In the animal model no significant differences could be found between myelodysplastic, leukaemic, and control animals.

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Blood and Bone Marrow Follow-Up Studies on Patients with Preleukemic States — Observation of Different Phases of the Evolving Leukemic Process

Cited by 5 publications

References 4 publications

Cytochemical Investigations on the Blood and Bone Marrow Cells in Preleukemia — Demonstration of Maturational Anomalies

Cytochemical Investigations on the Blood and Bone Marrow Cells in Preleukemia — Demonstration of Maturational Anomalies

On the pathogenesis of preleukemic myelodysplastic syndromes

Bone marrow mast cell reaction in preleukaemic myelodysplasia and in aplastic anaemia

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