Blood cadmium levels as a marker for early lung cancer detection

Lener, Marcin; Reszka, Edyta; Marciniak, Wojciech; Lesicka, Monika; Baszuk, Piotr; Jabłońska, Ewa; Białkowska, Katarzyna; Muszyńska, Magdalena; Pietrzak, S.; Derkacz, Róża; Grodzki, Tomasz; Wójcik, Janusz; Wojtyś, Małgorzata; Dębniak, Tadeusz; Cybulski, Cezary; Gronwald, Jacek; Kubisa, Bartosz; Pieróg, Jarosław; Waloszczyk, Piotr; Scott, Rodney J.; Jakubowska, Anna; Narod, Steven A.; Lubiński, Jan

doi:10.1016/j.jtemb.2020.126682

Cited by 36 publications

(20 citation statements)

References 23 publications

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“…This study suggests the possibility of estimating dietary Cd burden from Cd in blood for the general population (Ikeda et al, 2011). In another recent casecontrol study, BCL was proposed as a valuable indicator for early lung cancer detection (Lener et al, 2021). Furthermore, the identification for environmental sources or dietary exposure to Cd were not included in this investigation, hence we were not able to adjust for other cofounders which could determine Cd exposure.…”

Section: Discussionmentioning

confidence: 96%

Environmental Cadmium Exposure Promotes the Development, Progression and Chemoradioresistance of Esophageal Squamous Cell Carcinoma

Chen

Zhou²,

Lin³

et al. 2022

Front. Cell Dev. Biol.

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Cadmium (Cd) exposure has been implicated in the etiology of esophageal squamous cell carcinoma (ESCC), albeit with inconsistent results from epidemiologic studies and without causal evidence. In this study, we explore the relationship of Cd exposure and the development, progression and therapeutic resistance of ESCC. A total of 150 ESCC patients and 177 matched controls from a coastal region with a high incidence of ESCC in China were included in the study. It was found that the median blood Cd level (BCL) was significantly higher in ESCC patients than that in the controls. Odds ratios for ESCC risk were 3.12 (95% CI 1.54-6.30) and 3.71 (95% CI 1.84-7.48) in the third and fourth quartiles of Cd distribution, respectively. Notably, BCL above 4.71 μg/L was strongly associated with shorter progression-free survival time compared to that below 1.60 μg/L (p < 0.001). The chronic Cd-treated ESCC cells (CCT-ESCC) CCT-EC109 and CCT-EC9706 exhibited increased cell proliferation and tumorigenesis, enhanced migration and invasion, and upregulated EMT biomarkers following 12 weeks of exposure to 5 μM cadmium chloride. Furthermore, Cd treatment attenuated the efficacy of 5-fluorouracil, cisplatin and irradiation treatment in CCT-ESCC cells both in vitro and in vivo. Moreover, we revealed that Cd stimulated the cancer cell stemness and Wnt/β-catenin signaling pathway in the CCT-ESCC cells. Additionally, 5-aza-2-deoxy-cytidine treatment resulted in suppression of the Wnt/β-catenin signaling pathway and rescue of the Cd-induced cell radioresistance. These results offer new insights into the role of environmental Cd exposure in the development, progression and chemoradioresistance of ESCC.

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Section: Discussionmentioning

confidence: 96%

Environmental Cadmium Exposure Promotes the Development, Progression and Chemoradioresistance of Esophageal Squamous Cell Carcinoma

Chen

Zhou²,

Lin³

et al. 2022

Front. Cell Dev. Biol.

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“…Blood Cd examination in a person who has never smoked by Lener et. al (2021) showed a considerable number, so it was possible that the source of Cd could be obtained from outside smoking activities [26]. Food is a common source of Cd, but in smokers or in the form of smoke as a result of smoking activity can be the dominant source of Cd exposure [27].…”

Section: Discussionmentioning

confidence: 99%

Differences In Cadmium (Cd) Levels In The Blood of Active Smokers And Passive Smokers With Type 2 Diabetic In Puskesmas Kedungdoro Surabaya

Rahayuningsih

Puspitasari

2022

j.teknokes

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The degree of smoking habits in the urban community is still high, although carried out health promotion of harmful substances in cigarettes, one of which is cadmium (Cd). The dangers of cadmium in cigarette smoke causes harm to active and passive smokers. Increased exposure of cigarettes will lead to an increase in the burden of disease in groups at risk such as people with Diabetic Type 2 (DMT2). The purpose of this study was to determine the differences in levels of cadmium (Cd) in the blood of active smokers and passive smokers patients with DMT2 in Puskesmas Kedungdoro Surabaya. The type of this research is a comparative with cross-sectional study design conducted in the Toxicology Laboratory of the Department of Health Analyst and Research and Standardization Center of Industry in August 2020-May 2021. The independent variable in this study is active smokers and passive smokers patients with DMT2, and the dependent variable in this research is the content of cadmium (Cd) in the blood. Analysis of the levels of cadmium in the blood using Atomic Absorption Spectrophotometer by the method of acidifying carbon furnaces. The results showed range levels of cadmium in blood in 8 people suffer from Type 2 Diabetic as active smokers are 0.605-1.5535 µg/dL. While the range levels of cadmium in the blood of the 8 people who suffer from Type 2 Diabetic as passive smoking are 0.5648-2.7045 µg/dL. Based on the results of statistical tests using test Independent Sample T-Test, it can be concluded that there is no difference in the levels of cadmium (Cd) in active smokers and passive smokers patients with DMT2 in Puskesmas Kedungdoro Surabaya.

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“…According to the International Agency for Research on Cancer (IARC), Cd is a Group 1 carcinogen for humans and is associated with the incidence of lung cancer [88]. Heavy metals have the ability to replace important elements in human body, e.g., Cd has an atomic structure very similar to that of Zn, and fits almost perfectly into the Zn binding sites of important enzymes such as RNA transferase, carboxypeptidase and alcohol dehydrogenase [89].…”

Section: Concentration Of Heavy Metals In Plant Samplesmentioning

confidence: 99%

Heavy Metals Presence in the Soil and Their Content in Selected Varieties of Chili Peppers in Slovakia

Lidiková

Čeryová

Šnirc

et al. 2021

Foods

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Capsicum chili peppers are popular vegetables in Slovakia. They provide a supply of health-promoting substances, but contaminated vegetables can pose a serious health risk to the people who consume them. Therefore, the aim of this study was to determine the content of heavy metals (Mn, Zn, Cr, Cu, Ni, Cd, Pb and Hg) in the soil as well as in selected varieties of the genus Capsicum grown in southern Slovakia. The results were compared with the limit values given by the Law no. 220/2004 (valid in the SR) as well as threshold values proposed by the European Commission (EC) (2006). The gained result showed that the total content of Cd (1.64 mg/kg) as well as the available mobile forms of Cd (0.12 mg/kg) and Pb (0.26 mg/kg) was exceeded on the soil on which Capsicum cultivars were grown. The limit values of other monitored heavy metals (Mn, Zn, Cr, Cu, Ni, and Hg) were not exceeded. The studied species of the genus Capsicum did not accumulate monitored heavy metals. It can be stated that consumption of chili peppers does not pose any risk for human health.

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Blood cadmium levels as a marker for early lung cancer detection

Cited by 36 publications

References 23 publications

Environmental Cadmium Exposure Promotes the Development, Progression and Chemoradioresistance of Esophageal Squamous Cell Carcinoma

Environmental Cadmium Exposure Promotes the Development, Progression and Chemoradioresistance of Esophageal Squamous Cell Carcinoma

Differences In Cadmium (Cd) Levels In The Blood of Active Smokers And Passive Smokers With Type 2 Diabetic In Puskesmas Kedungdoro Surabaya

Heavy Metals Presence in the Soil and Their Content in Selected Varieties of Chili Peppers in Slovakia

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