Blood count parameters as a marker for metabolic syndrome in older adults

Oliveira, Carolina Cunha de; Roriz, Anna Karla Carneiro; Ramos, Lílian Barbosa; Neto, Mansueto Gomes

doi:10.1016/j.exger.2017.06.018

Cited by 7 publications

(6 citation statements)

References 17 publications

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“…Metabolic syndrome is associated with increased WBCs. A cross-sectional study that analyzed 203 older adults with an average age of 80.2 years showed that the chance of developing metabolic syndrome was 2.4 times higher than when using the cut-off points of a receiver operating characteristic curve [ 10 ]. In a cross-sectional study conducted in a young population whose average age was 41.3 years, an increase in WBCs indicated that the chances of developing metabolic syndrome were high even after calibrating for other confounding factors (OR: 1.26, 95% CI: 1.01–1.58) [ 11 ].…”

Section: Wbc Parametersmentioning

confidence: 99%

Usefulness of Complete Blood Count (CBC) to Assess Cardiovascular and Metabolic Diseases in Clinical Settings: A Comprehensive Literature Review

Seo

Lee

2022

Biomedicines

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Complete blood count (CBC) is one of the most common blood tests requested by clinicians and evaluates the total numbers and characteristics of cell components in the blood. Recently, many investigations have suggested that the risk of cancer, cardiovascular disease (CVD), arteriosclerosis, type 2 diabetes (T2DM), and metabolic syndrome can be predicted using CBC components. This review introduces that white blood cell (WBC), neutrophil-to-lymphocyte ratio (NLR), hemoglobin (Hb), mean corpuscular volume (MCV), red cell distribution width (RDW), platelet count, mean platelet volume (MPV), and platelet-to-lymphocyte ratio (PLR) are useful markers to predict CVD and metabolic diseases. Furthermore, we would like to support various uses of CBC by organizing pathophysiology that can explain the relationship between CBC components and diseases.

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Section: Wbc Parametersmentioning

confidence: 99%

Usefulness of Complete Blood Count (CBC) to Assess Cardiovascular and Metabolic Diseases in Clinical Settings: A Comprehensive Literature Review

Seo

Lee

2022

Biomedicines

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“…Previous studies have reported independent associations of hematological parameters with the risk for incident type 2 diabetes, although limited data are available on the associations of these parameters with GDM. Clinical studies have shown that the blood cell count is related to insulin resistance and metabolic syndrome, which may be a high-risk factor for GDM [12–15] . These findings led us to conclude that the elevated levels of platelets and erythrocytes in peripheral blood do not necessarily serve as a unique marker of chronic hypoxia or blood coagulation, but may be related to inflammation — a marked characteristic of insulin resistance and GDM.…”

Section: Introductionmentioning

confidence: 96%

“…Clinical studies have shown that the blood cell count is related to insulin resistance and metabolic syndrome, which may be a high-risk factor for GDM. [12][13][14][15] These findings led us to conclude that the elevated levels of platelets and erythrocytes in peripheral blood do not necessarily serve as a unique marker of chronic hypoxia or blood coagulation, but may be related to inflammationa marked characteristic of insulin resistance and GDM. Previous studies have shown that hypertensive disorders of pregnancy are associated with increased systemic inflammation, as depicted by the platelets in gravidas.…”

Section: Introductionmentioning

confidence: 99%

Distribution of complete blood count constituents in gestational diabetes mellitus

Zhang¹,

Zhang²,

Zhao³

et al. 2021

Medicine

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Background (Trial Design): The incidence rate of gestational diabetes is high. In the long run, it harms the health of both the mother and child. In order to understand the distribution of hematological cells with gestational diabetes mellitus (GDM), a longitudinal cohort study was conducted from 2012 to 2018. Methods: A longitudinal case control study of 1860 pregnant women was conducted between 2012 and 2018. Data of hematological parameters at 11 time points of gestational stage were obtained from a laboratory database. Repeated measures analysis and independent t-test were used to analyze the effect of the hematological parameters on GDM. Results: The trend of blood cells fluctuated with gestational age in normal controls but was more remarkable in GDM. Compared with the controls, blood neutrophils, lymphocytes, and monocytes augmented in the second trimester but decreased in the third trimester; platelet (PLT) and thrombocytocrit increased throughout the three trimesters, and red blood cell (RBC) was abundant in the last 2 trimesters in GDM. Conclusions: Peripheral blood leukocytes, platelets, and erythrocytes were significantly different during gestation between GDM and normal controls. Inflammation may also be involved in GMD.

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“…Some groups have claimed that the platelet count (PC) and the platelet lymphocyte ratio (PLR) are valid biomarker of MetS and correlated with the severity of MetS 10–14 . However these are not uniform observations and in a prospective study the PC failed to predict MetS 15–17 . In our carefully curated cohort with stringent inclusion, and exclusion criteria we showed no significant differences in both PC and PLR between nascent MetS and matched controls 18 …”

Section: Introductionmentioning

confidence: 53%

The platelet to high density lipoprotein ‐cholesterol ratio is a valid biomarker of nascent metabolic syndrome

Jialal

Adams‐Huet

2020

Diabetes Metabolism Res

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Aims The metabolic syndrome (MetS) is a major global problem, and inflammation and insulin resistance appear to be key underpinnings in this cardio‐metabolic cluster. MetS predisposes to an increased risk of diabetes and atherosclerotic cardiovascular disease (ASCVD). It has a procoagulant diathesis which included increased platelet activity and impaired fibrinolysis. High density lipoprotein (HDL) appears to be anti‐thrombotic. Accordingly, we examined the ratios between platelets to HDL‐cholesterol(C) and adiponectin (Adipo) in patients with nascent MetS without the confounding of diabetes, ASCVD and smoking to determine their validity as biomarkers of MetS. Methods Patients with nascent MetS (n = 58) and matched controls (n = 44) were recruited. Fasting blood samples were obtained for complete blood counts, basic metabolic panel, lipids, insulin, and Adipo. Ratios of platelets to HDL‐C and Adipo were calculated. Results Following adjustment for adiposity, only the platelet: HDL ratio was significantly increased in MetS and increased with severity of MetS. Receiver operating characteristic curve analysis showed that the platelet: HDL‐C area under the curve (AUC) significantly added to both platelets and platelet lymphocyte ratio AUCs. Also the platelet: HDL‐C ratio correlated with all cardio‐metabolic features of MetS, high sensitivity C‐reactive protein, insulin resistance chemerin, and leptin. Conclusions The ratio of platelets: HDL‐C is significantly increased in patients with nascent MetS and appear to be a valid biomarker of MetS. It could also emerge as a biomarker for athero‐thrombotic risk. However, these preliminary findings need confirmation in large prospective studies.

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Blood count parameters as a marker for metabolic syndrome in older adults

Cited by 7 publications

References 17 publications

Usefulness of Complete Blood Count (CBC) to Assess Cardiovascular and Metabolic Diseases in Clinical Settings: A Comprehensive Literature Review

Usefulness of Complete Blood Count (CBC) to Assess Cardiovascular and Metabolic Diseases in Clinical Settings: A Comprehensive Literature Review

Distribution of complete blood count constituents in gestational diabetes mellitus

The platelet to high density lipoprotein ‐cholesterol ratio is a valid biomarker of nascent metabolic syndrome

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