Blood lactate level in Wistar rats after four and twelve week intermittent aerobic training

Sari, Dewi Nur Puspita; Endardjo, Sutjahjo; Santoso, Dewi Irawati Soeria

doi:10.13181/mji.v22i3.582

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…The values of blood gas measurements (glucose, lactate, and creatinine) performed on diabetic rats are shown in Table . In a study carried out using STZ‐induced diabetic rats, the mean values for glucose, lactate, and creatinine were found as 611 ± 32.78 mg/dL, 3.18 ± 0.03 mmol/L, and 0.55 ± 0.06 mg/dL, respectively . There is no significant difference between all of the hemostatic dressings in relation to their glucose and lactate values although the lactate level showed an insignificant rise for SF/PC‐coated BC/CTS and SF‐coated Vit K/BC/CTS hemostatic dressings.…”

Section: Resultsmentioning

confidence: 95%

“…In a study carried out using STZ-induced diabetic rats, the mean values for glucose, lactate, and creatinine were found as 611 6 32.78 mg/dL, 3.18 6 0.03 mmol/L, and 0.55 6 0.06 mg/dL, respectively. [41][42][43] There is no significant difference between all of the hemostatic dressings in relation to their glucose and lactate values although the lactate level showed an insignificant rise for SF/PC-coated BC/CTS and SF-coated Vit K/BC/CTS hemostatic dressings. The average blood gas values in diabetic rats created by the femoral artery injury model are presented in Table III.…”

Section: Diabetic Rat Injury Modelmentioning

confidence: 88%

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Active nano/microbilayer hemostatic agents for diabetic rat bleeding model

et al. 2016

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Patients with diabetes mellitus have an increased cardiovascular risk due to the abnormality of hemostatic system components. Therefore, hemostasis is an important concept when considering that diabetics are under risk due to potential bleeding complications during surgical operation. The aim of our study was to examine the efficiency of a fabricated nano/microbilayer hemostatic dressing for bleeding control in diabetic patients. For this purpose, we prepared a nano/microbilayer hemostatic dressing that has a porous sublayer, including chitosan (CTS), bacterial cellulose (BC) as basement and active agents in coagulation cascade, such as vitamin K (Vit K), protamine sulfate (PS), and kaolin (Kao) as a filler and an upper layer consisting of silk fibroin (SF) or SF/phosphatidylcholine (PC) blend to achieve complete hemostasis in diabetic rats. Coagulative performances of the prepared hemostatic dressings were examined by the determination of bleeding time, blood loss, and mortality rate through diabetic rat femoral artery injury model. The percent of diabetic rat blood absorption was found to be 247 ± 5% for gauze as opposed to 2214 ± 56% for SF-coated PS/BC/CTS. Vit K-reinforced within 138 s and SF-coated BC/CTS hemostatic dressings within 144 s showed a rapid coagulation time. In vivo coagulation studies demonstrated that hemostatic agent-reinforced BC/CTS hemostatic dressing, especially PS/BC/CTS showed a significant hemostatic plug formation. This study suggests that the high positive charge and porosity give to these hemostatic agents reinforced hemostatic dressings the ability to rapidly swell and to promote the accumulation of red blood cells and platelets through electrostatic interactions. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1573-1585, 2017.

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Section: Resultsmentioning

confidence: 95%

Section: Diabetic Rat Injury Modelmentioning

confidence: 88%

Active nano/microbilayer hemostatic agents for diabetic rat bleeding model

et al. 2016

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“…The normal blood lactic acid value in humans is 1.0-2.0 mmol/l (Jia, Wang and Yu, 2017). Sari shows that lactic acid levels are normally at 0-4 mmol/l (Sari, Endardjo and Santoso, 2013). The increase in lactic acid in the blood which exceeds 4 mmol / l and does not reduce after resuscitation indicates the probability of organ damage (Leksana, 2010).…”

Section: Introductionmentioning

confidence: 99%

Correlation between Individual Characteristics and Work Position with Work Fatigue on Workers

Yudisianto

Tualeka

Widajati

2021

IJOSH

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Introduction: Work fatigue is a condition of decreased efficiency and resilience of workers, which can interfere the companys’ productivity. Job fatigue can be caused by the performance, duration, and effort (work position) of the workers. Based on the observations, workers at the expedition sub units of PT X needed to lift 200 to 400kg heavy loads. The activity of lifting very heavy weights can cause fatigue. One form of physical fatigue indicators is an increase in lactic acid in the blood. The purpose of this study was to analyze the correlation between workers’ characteristics and work position with work fatigue among workers in the expedition sub units of PT X. Methods: This research was a quantitative study with a cross sectional design. The population of this study was 36 people. This research used total sampling. The independent variable were individual characteristics and work position as measured using REBA tools, and the dependent variable was work fatigue as measured using lactic acid levels in blood. Data was analyzed using statistical tools to obtain the value of correlation coefficient between variables. Result: The results showed that there was a weak positive correlation between workers’ characteristics and physical fatigue. The results showed that the coefficient value between work position and physical fatigue was 0.354. The coefficient figure indicated a weak positive correlation between work position and work fatigue. Conclusion: There was a correlation between work position and work fatigue in workers.Keywords: ergonomics, lactic acid, REBA, work fatigue, work position .

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Hemostatic activities of nano/microporous bilayer dressings in a femoral artery bleeding rat model

Karahaliloğlu

Demirbilek

Ulusoy

et al. 2016

J of Applied Polymer Sci

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Recently, an effective hemostatic dressing requirement has become a major problem in both the military and civilian world. Available hemostatic agents are too expensive, ineffective, unsafe, or complicated to use. Here, we evaluated the hemostatic efficacy of a nano/micro bilayer hemostatic dressing including a porous sublayer from chitosan (CTS) and bacterial cellulose (BC) and a nanofibrillar upper layer from silk fibroin (SF). In addition, several active agents rolled in coagulation cascade [vitamin K (Vit K), protamine sulfate (PS), kaolin (Kao), etc.] were doped to the sublayer of bilayer hemostatic agent and their activities were compared via in vivo and in vitro tests. Lactate dehydrogenase (LDH) activity test results demonstrated that BC/CTS, SF-coated BC/CTS, and Vit K K/BC/CTS, SF/phosphatidylcholine (PC)-coated BC/CTS showed higher LDH activity compared to standard gauze (p < 0.005). In a femoral artery bleeding rat model, SF-coated PS/BC/CTS significantly reduced bleeding time (80 6 0.3 s) compared to standard gauze and kaolin-doped group (p < 0.005). Blood loss and mortality rate with 2.3 g and 37.5% SF-coated BC/CTS and SF-coated PS/BC/CTS showed increased efficacy in achieving hemostasis compared to standard gauze. All the prepared hemostatic dressings except for kaolin-doped BC/CTS and standard gauze induced no inflammatory reaction in the tissue. All these data suggest that active agent-doped BC/CTS/SF-based bilayer hemostatic dressings have a great influence on the resulting hemostatic action. V C 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43657.

show abstract

Blood lactate level in Wistar rats after four and twelve week intermittent aerobic training

Cited by 4 publications

References 10 publications

Active nano/microbilayer hemostatic agents for diabetic rat bleeding model

Active nano/microbilayer hemostatic agents for diabetic rat bleeding model

Correlation between Individual Characteristics and Work Position with Work Fatigue on Workers

Hemostatic activities of nano/microporous bilayer dressings in a femoral artery bleeding rat model

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