Blood plasma model predictions for the proposed bone-seeking radiopharmaceutical [117mSn]Sn(IV)-N,N′,N′-trimethylenephosphonate-poly(ethyleneimine)

Jansen, David R.; Krijger, Gerard C.; Wagener, Judith; Senwedi, Ratanang M.; Gabanamotse, Kenneth; Kgadiete, Mpho; Kolář, Z.; Zeevaart, Jan Rijn

doi:10.1016/j.jinorgbio.2009.07.007

Cited by 8 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More recently, a PEI-mediated gene and drug codelivery has been reported . However, forms of PEI-based bone-seeking nanoplatforms functionalized with BP are scarce in the literature and the reported advances have focused on the development of radiopharmaceuticals. − PEI is attractive due to its intrinsic properties: defined size and molecular weight, high solubility in various solvents, including water, and, more remarkably, a high density of amine functional groups that are available for covalent chemical conjugation. Furthermore, PEI exhibits an inherent electrostatic attraction toward HA due to the complementary ionic character of both compounds, since HA shows a slightly negative surface charge under physiological conditions .…”

Section: Results and Discussionmentioning

confidence: 99%

Polyethylenimine–Bisphosphonate–Cyclodextrin Ternary Conjugates: Supramolecular Systems for the Delivery of Antineoplastic Drugs

et al. 2021

View full text Add to dashboard Cite

Bisphosphonates (BPs) are bone-binding molecules that provide targeting capabilities to bone cancer cells when conjugated with drug-carrying polymers. This work reports the design, synthesis, and biological evaluation of polyethyleneimine–BP–cyclodextrin (PEI-BP-CD) ternary conjugates with supramolecular capabilities for the loading of antineoplastic drugs. A straightforward, modular, and versatile strategy based on the click aza-Michael addition reaction of vinyl sulfones (VSs) allows the grafting of BPs targeting ligands and βCD carrier appendages to the PEI polymeric scaffold. The in vitro evaluation (cytotoxicity, cellular uptake, internalization routes, and subcellular distribution) for the ternary conjugates and their doxorubicin inclusion complexes in different bone-related cancer cell lines (MC3T3-E1 osteoblasts, MG-63 sarcoma cells, and MDA-MB-231 breast cancer cells) confirmed specificity, mitochondrial targeting, and overall capability to mediate a targeted drug transport to those cells. The in vivo evaluation using xenografts of MG-63 and MDA-MB-231 cells on mice also confirmed the targeting of the conjugates.

show abstract

Section: Results and Discussionmentioning

confidence: 99%

Polyethylenimine–Bisphosphonate–Cyclodextrin Ternary Conjugates: Supramolecular Systems for the Delivery of Antineoplastic Drugs

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In vitro tests demonstrated that fractionated N,N’,N’ -trimethylenephosphonate-poly(ethyleneimine) (PEI-MP) was able to carry radioactive tin ions to an HAp surface and then release them upon contact. By doing so, PEI-MP may work well as an imaging agent and as a possible radiotherapy delivery agent for metastatic bone cancer [97,98]. As such, prevention of any biocompatibility issues may be avoided by integrating PEI-MP into a block-copolymer of a more biocompatible polymer.…”

Section: Polymer Carriersmentioning

confidence: 99%

“…Jansen et al demonstrated effective HAp binding of Sn 2+ and Sn 4+ chelated PEI-MP. In order to demonstrate the EPR effect in combination with HAp adsorption, however, an in vivo study is still necessary [97,98]. Although more tests are needed in order to determine the efficacy of delivering radiolabeled polymers to bone metastases, one must still be curious about the possibilities.…”

Section: Therapeuticsmentioning

confidence: 99%

Targeting polymer therapeutics to bone

Low

Kopeček

2012

Advanced Drug Delivery Reviews

136

View full text Add to dashboard Cite

An aging population in the developing world has led to an increase in musculoskeletal diseases such as osteoporosis and bone metastases. Left untreated many bone diseases cause debilitating pain and in the case of cancer, death. Many potential drugs are effective in treating diseases but result in side effects preventing their efficacy in the clinic. Bone, however, provides an unique environment of inorganic solids, which can be exploited in order to effectively target drugs to diseased tissue. By integration of bone targeting moieties to drug-carrying water-soluble polymers, the payload to diseased area can be increased while side effects decreased. The realization of clinically relevant bone targeted polymer therapeutics depends on (1) understanding bone targeting moiety interactions, (2) development of controlled drug delivery systems, as well as (3) understanding drug interactions. The latter makes it possible to develop bone targeted synergistic drug delivery systems.

show abstract

“…Phosphorous‐containing materials have garnered increased attention in recent years due to their potential use in various applications, particularly as flame retardants, but also in biomedical applications, as fuel cell membranes, as corrosion inhibiting agents, and as metal chelators . Such materials have been synthesized via a number of different approaches, depending on the intended application.…”

Section: Introductionmentioning

confidence: 99%

Aminobisphosphonate Polymers via RAFT and a Multicomponent Kabachnik–Fields Reaction

Bachler

Schülz

Sparks

et al. 2015

Macromol. Rapid Commun.

View full text Add to dashboard Cite

Polyacrylamides containing pendant aminobisphosphonate groups are synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization and a multicomponent postpolymerization functionalization reaction. A Moedritzer-Irani reaction installs the phosphonic acid groups on well-defined, RAFT-generated polymers bearing a pendant amine. An alternate route to the same materials is developed utilizing a three-component Kabachnik-Fields reaction and subsequent dealkylation. Kinetics of the RAFT polymerization of the polymer precursor are studied. Successful functionalization is demonstrated by NMR and FTIR spectroscopy and elemental analysis of the final polymers.

show abstract

Blood plasma model predictions for the proposed bone-seeking radiopharmaceutical [117mSn]Sn(IV)-N,N′,N′-trimethylenephosphonate-poly(ethyleneimine)

Cited by 8 publications

References 18 publications

Polyethylenimine–Bisphosphonate–Cyclodextrin Ternary Conjugates: Supramolecular Systems for the Delivery of Antineoplastic Drugs

Polyethylenimine–Bisphosphonate–Cyclodextrin Ternary Conjugates: Supramolecular Systems for the Delivery of Antineoplastic Drugs

Targeting polymer therapeutics to bone

Aminobisphosphonate Polymers via RAFT and a Multicomponent Kabachnik–Fields Reaction

Contact Info

Product

Resources

About