Blood platelet activation and increase in thrombin activity following a marathon race

Röcker, L.; Drygas, Wojciech; Heyduck, B.

doi:10.1007/bf00422736

Cited by 52 publications

(49 citation statements)

References 36 publications

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“…All blood samples were taking with subjects lying down in order to rule out orthostatic changes in plasma volume (18). The results of authors with comparable collectives and methods to ours (11,13,15,16) confirm our measurements of changes in plasma volume. Previous studies had not reported a positive correlation of the plasma volume increase from 3 to 34 hr post marathon with the runners' years of training.…”

Section: Discussionsupporting

confidence: 84%

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Neopterin, IgG, IgA, IgM, and Plasma Volume Changes During Long-distance Running

et al. 2002

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Prolonged physical exercise is associated with several immunological changes, e.g. increase in proinflammatory cytokines, changes in the white blood count etc. Great discrepancies exist with regard to the exercise-induced influence on serum immunoglobulin and neopterin values. One explanation could be the shifts in plasma volume (PV) during and after exercise which might influence plasma concentrations of these parameters. Therefore we investigated the consequences of a marathon race in a homogenous group of experienced runners on plasma volume shifts, serum Immunglobulin and neopterin concentrations. Plasma values with and without correction for plasma volume shifts were compared. PV was significantly diminished after the race (-8.4%) followed by a rise 34h after finish (+8.5%). Serum immunoglobulin IgG, IgA and IgM were increased within the first hours postmarathon and normalized in the recovery period. When chages in PV were considered, only IgA rose significantly. Serum neopterin remained unchanged after the marathon independently whether corrected for PV changes or not. We conclude that the increase in immunoglobulins in our study was mainly the consequence of plasma volume changes. Since neopterin was unchanged we have at least in our study no evidence for exercise-induced activation of the cellular immune system.

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Section: Discussionsupporting

confidence: 84%

“…The changes in plasma volume described here are relatively high compared to previous publications (11)(12)(13)(14)(15)9,16). These test groups were to some extent very heterogenous with respect to gender and level of training (14,17,9) or consisted of very few subjects e.g.…”

Section: Discussionmentioning

confidence: 52%

Neopterin, IgG, IgA, IgM, and Plasma Volume Changes During Long-distance Running

et al. 2002

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“…31 Schernthaner et al 32 found a 2-to 3-fold increase in β-thromboglobulin and PF4 levels after exercise. Placanica and colleagues 33 reported that patients with ischemic heart disease had high basal concentrations of PF4 and that these levels increased with exercise.…”

Section: Discussionmentioning

confidence: 98%

Effects of Marathon Running on Platelet Activation Markers

et al. 2006

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We used the ADVIA 2120 Hematology System (Bayer HealthCare, Diagnostics Division, Tarrytown, NY) to study the effects of vigorous exercise on CBC count, WBC differential, RBC fragmentation, and platelet activation parameters in 32 healthy participants in a 26.2-mile (42.2-km) marathon. The runners demonstrated increases in hematocrit and platelet count consistent with dehydration and leukocytosis indicative of demargination of neutrophils or inflammation secondary to tissue destruction (eg, rhabdomyolysis). The number of RBC fragments was increased after the race (P = .008), consistent with exercise-induced hemolysis. The mean platelet component, a measure of platelet granularity, was decreased (P < .0001), and the number of platelet clumps was increased (P = .0026), providing evidence for in vivo platelet activation during the marathon. By using direct measurement of platelet granularity, our study confirms the in vivo activation of platelets by vigorous exercise and establishes the usefulness of automated cell counters for the assessment of platelet activation and of RBC fragmentation in this setting.

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“…Also, based on one marathon study, despite increased levels of B-thromboglobulin, platelet aggregation was found to decrease after exercise (Rock et al, 1997). Platelet activation during exercise may be related to shear stress causing endothelial damage, increase in plasma thrombin generation, catecholamines and mobilezation of more active platelets from the reticuloendothelial system (Rocker et al, 1986). Based on the results presented in this study, it was observed that TT significantly increased on different tissues in EP rats after short and long times physical activity (Tables 3 and 4).…”

Section: Discussionmentioning

confidence: 99%

Effects of physical activity on some of hemostatic parameters changes in epiphysectomized rats

Rostami¹

2011

Afr. J. Pharm. Pharmacol.

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This study was designed to determine the effects of physical activity on thrombin time and coagulation time in epiphysectomized rats. Male Wistar rats (n = 60) weighing 90 to 100 g were divided into 2 groups; control group (without epiphysectomy) and experimental group (epiphysectomy). In each group, animals were divided into three subgroups: control (without physical activity), short-time (5 min physical activity) and long-time (with 20 min physical activity). Blood samples were collected from rat tail tip in several stages as before and after epiphysectomy and physical activity from experimental group, to determine coagulation time. Exercise programs were performed including; swimming on water pool until 5 min (short-time) and 20 min (long-time) in experimental and control groups. Autopsy was done on all the rats. Thrombin time was measured for each tissue. Our data showed that physical activity significantly decreased thrombin time on tissues of rats as compared to baseline values in control group (P < 0.001). In contrast, physical activity significantly increased thrombin time on different tissues in epiphysectomy rats (P < 0.001). Also, our results showed that in epiphysectomized rats after long-time physical activity, coagulation time increased but after short-time it decreased. In conclusion, these results suggest that there is a functional relationship between the pineal gland and the exercise on changes of hemostatic parameters in blood via its hormone melatonin.

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Blood platelet activation and increase in thrombin activity following a marathon race

Cited by 52 publications

References 36 publications

Neopterin, IgG, IgA, IgM, and Plasma Volume Changes During Long-distance Running

Neopterin, IgG, IgA, IgM, and Plasma Volume Changes During Long-distance Running

Effects of Marathon Running on Platelet Activation Markers

Effects of physical activity on some of hemostatic parameters changes in epiphysectomized rats

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