Blood pressure response to catheter-based renal sympathetic denervation in severe resistant hypertension: data from the Greek Renal Denervation Registry

Abstract

In our "real-world" multicenter national registry, the efficacy of renal denervation in reducing BP as well as safety is confirmed during a 12-month follow-up. Moreover, younger age, obesity, and higher levels of baseline systolic BP are independently related to better BP response to RDN.

Catheter-based renal denervation in hypertension

“…These data are in line with positive results of major registries [7], for example, from the United Kingdom [8], Austria [9], and Greece [10]. Such observational data are key to appreciate the efficacy and safety of real-world patients undergoing RDN outside of controlled clinical studies.…”

Renal sympathetic denervation: Ashes to ashes or rebirth from the ashes?

“…The efficacy of an approach in real life is the most important parameter from the clinical point of view, because randomized controlled trials (despite their unique unbeatable characteristics) "suffer" from strict inclusion/exclusion criteria that might limit the generalization of findings, and the close follow-up and the strict protocol procedures might not be feasible in everyday clinical practice, thus calling into question the efficacy and safety in real-world conditions. The study by Denegri and colleagues provides reassuring reallife evidence, which is in line with local registries 23,24 and the Global Symplicity Registry. 25 Almost a decade later than the original proof-of-concept study, we are certainly wiser but we still remain dubious about the future of renal sympathetic denervation.…”

Predictors for success in renal denervation–a single centre retrospective analysis

“…Randomized sham-controlled SIMPLICITY HTN 3 trial confirmed these findings. Various registry analyses including experiences from different countries also found baseline BP as a major predictor of BP-lowering effect after RDN and confirmed data coming from proof-of-concept studies and randomized trials by the evidence from real-life setting 15 – 21 . Noteworthy, baseline SBP predicted lowering effect in SBP and baseline DBP predicted lowering effect in DBP in all previously mentioned studies.…”