Blood pressure responses to whole-body cold exposure: effect of metoprolol

Komulainen, Silja; Rintamäki, Hannu; Virokannas, Hannu; Keinänen‐Kiukaanniemi, Sirkka

doi:10.1038/sj.jhh.1001758

Cited by 14 publications

(14 citation statements)

References 8 publications

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“…The level of maximal blood pressure was reached during 3 min after the starting of the cold exposure, and blood pressure stayed almost on the same level during the whole exposure. Compared to previous studies, which have been carried out with normotensive and mildly hypertensive subjects with adequate winter clothing in the same test conditions, SBP and DBP responses are similar (Komulainen et al, 2000(Komulainen et al, , 2004. The magnitude of blood pressure response is comparable to that measured during stronger face cooling (Gavhed et al, 2000).…”

Section: Discussionsupporting

confidence: 70%

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Blood pressure and thermal responses to whole body cold exposure in mildly hypertensive subjects

Komulainen

Oja

Rintamäki

et al. 2004

Journal of Thermal Biology

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Section: Discussionsupporting

confidence: 70%

“…Whole body cold exposure (-15 1C and 3.5 m/s) with adequate winter clothing caused a rapid increase in blood pressure in mildly hypertensive subjects (Komulainen et al, 2000(Komulainen et al, , 2004. The cold-induced rise of blood pressure was maximally 28-34 (systolic, SBP) and 20-22 mmHg (diastolic, DBP).…”

Section: Introduction and Literaturementioning

confidence: 98%

Blood pressure and thermal responses to whole body cold exposure in mildly hypertensive subjects

Komulainen

Oja

Rintamäki

et al. 2004

Journal of Thermal Biology

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“…Our data obtained from the LAD artery support and extend upon these previous studies. There is debate over whether selective or nonselective ␤-blockers are more effective for use in a cold environment (5,35,36,56). Overall, we believe that ␤-mediated vasodilation plays an important role in offsetting the coronary vasoconstrictor response to forehead cooling in vivo.…”

Section: Discussionmentioning

confidence: 99%

β-Adrenergic blockade enhances coronary vasoconstrictor response to forehead cooling

Muller

Gao

Patel

et al. 2014

American Journal of Physiology-Heart and Circulatory Physiology

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Forehead cooling activates the sympathetic nervous system and can trigger angina pectoris in susceptible individuals. However, the effect of forehead cooling on coronary blood flow velocity (CBV) is not well understood. In this human experiment, we tested the hypotheses that forehead cooling reduces CBV (i.e., coronary vasoconstriction) and that this vasoconstrictor effect would be enhanced under systemic β-adrenergic blockade. A total of 30 healthy subjects (age range, 23-79 years) underwent Doppler echocardiography evaluation of CBV in response to 60 s of forehead cooling (1°C ice bag on forehead). A subset of subjects (n = 10) also underwent the procedures after an intravenous infusion of propranolol. Rate pressure product (RPP) was used as an index of myocardial oxygen demand. Consistent with our first hypothesis, forehead cooling reduced CBV from 19.5 ± 0.7 to 17.5 ± 0.8 cm/s (P < 0.001), whereas mean arterial pressure increased by 11 ± 2 mmHg (P < 0.001). Consistent with our second hypothesis, forehead cooling reduced CBV under propranolol despite a significant rise in RPP. The current studies indicate that forehead cooling elicits a sympathetically mediated pressor response and a reduction in CBV, and this effect is augmented under β-blockade. The results are consistent with sympathetic activation of β-receptor coronary vasodilation in humans, as has been demonstrated in animals.

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“…Studies report that a sudden exposure to the cold can increase the blood pressure of humans by 20 mmHg, especially when there exists cold induced pain at the same time [1,2]. A short period of persistent low temperature stress could also lead to blood pressure elevation in both human and animal subjects [3,4,5,6,7].…”

Section: Introductionmentioning

confidence: 99%

Effects of Cold Air on Cardiovascular Disease Risk Factors in Rat

Luo

Zhang

et al. 2012

IJERPH

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The purpose of this study is to explore possible potential implications of cold air in cardiovascular disease (CVD) risk in rats. Healthy Wistar rats were exposed to artificial cold air under laboratory conditions, and their systolic blood pressure, heart rate, vasoconstriction, CVD risk factors, and myocardial damage indicators after cold air exposure were determined and evaluated. Systolic blood pressure, whole blood viscosity, and plasma level of norepinephrine, angiotensinⅡ, low density lipoprotein, total cholesterol, and fibrinogen in treatment groups increased significantly compared with control groups. No significant variations were found in plasma Mb and cTnT and myocardial tissue between the treatment and control groups. Results indicate that: (1) higher levels of SBP, WBV and LDL/HDL, total cholesterol (TC), and FG in blood may indicate higher CVD risks during cold air exposure; (2) cold air may exert continuous impacts on SBP and other CVD risk factors.

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Blood pressure responses to whole-body cold exposure: effect of metoprolol

Cited by 14 publications

References 8 publications

Blood pressure and thermal responses to whole body cold exposure in mildly hypertensive subjects

Blood pressure and thermal responses to whole body cold exposure in mildly hypertensive subjects

β-Adrenergic blockade enhances coronary vasoconstrictor response to forehead cooling

Effects of Cold Air on Cardiovascular Disease Risk Factors in Rat

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