Blood Viscosity: Influence of Erythrocyte Aggregation

Chien, Shu; Usami, Shunichi; Dellenback, Robert J.; Gregersen, Magnus I.; Nanninga, L.B.; Guest, M. Mason

doi:10.1126/science.157.3790.829

Cited by 254 publications

(131 citation statements)

References 8 publications

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“…Valant et al 30 have reported the viscosity curves obtained for three female and three male healthy donors at 37 C with different hematocrit (Hct) values. For all donors, the viscosity was markedly shear-thinning confirming the early measurements of Chien et al 46,47 and Thurston 4 and providing evidence of contributions of both viscosity and elasticity in the rheology of whole blood (which will be separately evaluated as G 0 and G 00 afterwards). At low shear rates, the red blood cells tend to aggregate leading to a solid-like behavior, but as the shear rate is increased the red blood cells disaggregate and align with the flow imparting a liquid-like behavior to blood, with a reduced ability to store elastic energy.…”

Section: A Viscoelastic Properties Of Bloodsupporting

confidence: 62%

Viscoelasticity of blood and viscoelastic blood analogues for use in polydymethylsiloxane in vitro models of the circulatory system

et al. 2013

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The non-Newtonian properties of blood are of great importance since they are closely related with incident cardiovascular diseases. A good understanding of the hemodynamics through the main vessels of the human circulatory system is thus fundamental in the detection and especially in the treatment of these diseases. Very often such studies take place in vitro for convenience and better flow control and these generally require blood analogue solutions that not only adequately mimic the viscoelastic properties of blood but also minimize undesirable optical distortions arising from vessel curvature that could interfere in flow visualizations or particle image velocimetry measurements. In this work, we present the viscoelastic moduli of whole human blood obtained by means of passive microrheology experiments. These results and existing shear and extensional rheological data for whole human blood in the literature enabled us to develop solutions with rheological behavior analogous to real whole blood and with a refractive index suited for PDMS (polydymethylsiloxane) micro-and milli-channels. In addition, these blood analogues can be modified in order to obtain a larger range of refractive indices from 1.38 to 1.43 to match the refractive index of several materials other than PDMS. V C 2013 AIP Publishing LLC.

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Section: A Viscoelastic Properties Of Bloodsupporting

confidence: 62%

Viscoelasticity of blood and viscoelastic blood analogues for use in polydymethylsiloxane in vitro models of the circulatory system

et al. 2013

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“…Furthermore, human red blood cells were found [15] not to cohere in physiological saline solution free of macromolecules such as fibrinogens. Although this may be due to electrostatic repulsion, i.e.…”

Section: Discussionmentioning

confidence: 99%

Steric Interaction of Fluid Membranes in Multilayer Systems

Helfrich

1978

Zeitschrift Für Naturforschung A

1,061

435

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The out-of-plane fluctuations of fluid membranes are sterically hindered in multilayer systems. The repulsive interaction associated with the steric or excluded-volume effect is studied theoretically by two methods. The interaction energy per unit area of membrane is derived as a function of temperature, membrane curvature elasticity and mean membrane spacing; it is inversely proportional to the square of the latter. Steric repulsion is estimated for lecithin bilayers in water. There and in other cases, it may compete with van der Waals attraction.

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“…Age, smoking, fibrinogen, total serum proteins, and triglycerides were adjusted covariates. Lipoprotein variables were successively introduced in the multivariate models: apoA-I and apoB (model 1); LDL-C, HDL 2 …”

Section: Discussionmentioning

confidence: 99%

Influence of HDL subfractions on erythrocyte aggregation in hypercholesterolemic men. PCVMETRA Group.

Razavian

Atger

Giral

et al. 1994

Arterioscler Thromb

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Recent studies have suggested that rheological mechanisms may be involved in the pathogenesis of ischemic syndromes in hyperlipidemias. We investigated the association between erythrocyte aggregation and components of lipoproteins in the blood of 60 normotensive, hypercholesterolemic men aged 45±8 years. The rheological parameters assessed were aggregation index (AI) and disaggregation shear rate threshold (yt) as determined by laser reflectometry, plasma fibrinogen, total serum protein, and hematocrit. The lipoprotein variables included total cholesterol, triglycerides, highdensity lipoprotein (HDL) cholesterol and its subfractions HDL 2 cholesterol and HDL3 cholesterol, apolipoprotein (apo) B, apoA-I, HDL particles containing apoA-I without apoA-II (LpA-I), and HDL particles containing both apoA-I and apoA-II (LpA-I/A-II). Covariables considered for possible confounding effects were age, body mass index, and smoking behavior. Fibrinogen, total serum protein, and both aggregation parameters (AI and yt) were elevated in this hypercholesterolemic population. Univariate analysis showed that both T he fluidity of blood plays an important role in the physiological behavior of the circulation, and its alteration might promote cardiovascular complications in situations associated with low-flow states. 1In this condition red blood cells (RBCs) aggregate due to the increase in the bridging force of high-molecularweight plasma proteins.12 Among these proteins, some are considered to be cardiovascular risk markers (eg, lipoproteins, fibrinogen) and are associated with increased plasma and whole-blood viscosity.313 Associations between rheology and components of lipoproteins in human blood are reported. Studies in patients with various forms of hyperlipoproteinemia show a concentration-dependent increase in plasma viscosity for lowdensity lipoprotein cholesterol (LDL-C) and chylomicrons and hence, for total triglycerides. 9 ' 10 These earlier studies are in line with the positive linear correlation of plasma viscosity with total cholesterol and apolipoprotein (apo) A-II and apoB observed in a recent study. 11Moreover, both blood viscosity 11 and erythrocyte aggregation 12 are negatively related to high-density lipoprotein cholesterol (HDL-C) concentration, which is known to be inversely correlated with coronary heart disease risk. 14 Furthermore, HDL may also be separated according to apolipoprotein composition, leading to at least two species of particles: LpA-I, which contains apoA-I without apoA-II, and LpA-I/A-II, which contains both apoA-I and apoA-II. 15 These heterogeneous HDL subfractions seem to have distinct metabolic roles, but the specific effect of one or another particle on the atherosclerotic process remains unclear. 1621 In the present study we investigated the relation of lipoprotein components, and especially HDL subfractions, to the aggregation and disaggregation of RBCs in a population of asymptomatic, hypercholesterolemic, normotriglyceridemic, normotensive subjects. Methods Selection of Su...

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Blood Viscosity: Influence of Erythrocyte Aggregation

Cited by 254 publications

References 8 publications

Viscoelasticity of blood and viscoelastic blood analogues for use in polydymethylsiloxane in vitro models of the circulatory system

Viscoelasticity of blood and viscoelastic blood analogues for use in polydymethylsiloxane in vitro models of the circulatory system

Steric Interaction of Fluid Membranes in Multilayer Systems

Influence of HDL subfractions on erythrocyte aggregation in hypercholesterolemic men. PCVMETRA Group.

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