Bloodstream infection caused by Acinetobacter junii in a patient with acute lymphoblastic leukaemia after allogenic haematopoietic cell transplantation

Cayô, Rodrigo; Segundo, Lucrecia Yáñez San; Bernal, Inmaculada C. Pérez del Molino; Fuente, C. García de la; Rodríguez, Maria Aranzazu Bermúdez; Calvo, Jorge; Martínez-Martínez, Luis

doi:10.1099/jmm.0.024596-0

Cited by 20 publications

(13 citation statements)

References 16 publications

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“…It has been reported to be associated with septicaemia in neonates and paediatric oncology patients, 36–39 and with meningitis, 40 refractory peritonitis, 41 ocular infection 42 and bloodstream infections in patients with acute lymphoblastic leukemia. 43 Wang et al. 44 reported that A. pittii causes hospital-acquired pneumonia and Wisplinghoff et al.…”

Section: Discussionmentioning

confidence: 99%

Molecular characterization and antimicrobial susceptibility of bacterial isolates present in tap water of public toilets

Kaur

Singh

Kesavan

et al. 2019

International Health

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Background The present study was carried out to investigate the tap water quality of public toilets in Amritsar, Punjab, India. Methods Water samples from the taps of the public toilets were collected in sterile containers and physicochemical and bacteriological analysis was performed using standard methods. Also, genotypic and phenotypic characterization of the bacterial isolates was performed using different biochemical tests and 16S ribosomal RNA analysis. An antibiotic susceptibility test was performed using antibiotics based on their mode of action. A biofilm assay was performed to assess the adhesion potential of the isolates. Results A total of 25 bacterial isolates were identified from the water samples, including Acinetobacter junii, Acinetobacter pittii, Acinetobacter haemolyticus, Bacillus pumilus, Bacillus megaterium, Bacillus marisflavi, Bacillus flexus, Bacillus oceanisediminis, Pseudomonas otitidis, Pseudomonas sp. RR013, Pseudomonas sp. RR021, Pseudomonas sp. RR022, Escherichia coli and Enterobacter cloacae. The results of the antimicrobial susceptibility test revealed that the antibiotics cefodroxil, aztreonam, nitrofurantoin, cefepime, ceftazidime and amoxyclav were found to be mostly ineffective against various isolates. The biofilm assay revealed the weak, moderate and strong biofilm producers among them. Conclusions The tap water in the public toilets was microbially contaminated and needs to be monitored carefully. The antibiotic susceptibility profile showed that of 25 bacterial isolates, 5 were multidrug resistant. Bacterial isolates exhibited strong to weak adhesion potential in the biofilm assay.

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Section: Discussionmentioning

confidence: 99%

Molecular characterization and antimicrobial susceptibility of bacterial isolates present in tap water of public toilets

Kaur

Singh

Kesavan

et al. 2019

International Health

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“…Acinetobacter junii enfeksiyonlarının neonatal dönemde (12), pediatrik onkolojik hastalarda (13), yetişkin immün yetmezliği olan hastalarda septisemi nedeni (14,15) ve korneal perforasyon (16) nedeni olabileceği rapor edilmiştir. Kappstein ve ark.…”

Section: Discussionunclassified

“…Prashanth ve ark. (16) (15) ampirik tedavi olarak piperasilin/tazobaktam ile tedavi edilen bir hastada bu antimikrobiyal ajana duyarlı olmasına rağmen Acinetobacter junii'nin neden olduğu bir kan dolaşımı enfeksiyonu geliştiğini gözlemlemişlerdir. Ancak bu duruma bakteriyemi epizodu sırasında hastanın almakta olduğu kortikosteroid tedavisinin de neden olabileceği belirtilmiştir.…”

Section: Discussionunclassified

Mini Epidemic of Acinetobacter Junii in a Neonatal Intensive Care Unit: Risk Factors and Control Procedures

Sandal¹,

Çetin²,

Özen³

et al. 2015

jpr

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“…The metal content ( 24 Mg, 27 Al, 47 Ti, 53 Cr, 55 Mn, 56 Fe, 57 Fe, 59 Co, 60 Ni, 63 Cu, 66 Zn, 90 Zr, 107 Ag, 111 Cd, 202 Hg, and 208 Pb) of October 2017 wastewater samples were measured on an inductively coupled plasma mass spectrometry (ICP-MS) (Agilent 7500). Wastewater samples were filtered through 0.22 µm Whatman™ Puradisc 23-mm syringe filters (GE Healthcare, Little Chalfort, Buckinhamshire, UK) prior to measurement.…”

Section: Icp-msmentioning

confidence: 99%

“…Among members of this genus, Acinetobacter junii has been shown to be an opportunistic pathogen causing disease in individuals with known malignancies, or in those who had received prior antibiotic treatment or invasive procedures. The symptoms of infection with A. junii include septicemia, bacteremia, empyema, peritonitis and keratitis [25][26][27]. Members of this genus have also been shown to facilitate uptake of ARGs from E. coli through horizontal gene transfer at higher rates than other studied bacteria [28].…”

Section: Introductionmentioning

confidence: 99%

An Increase of Abundance and Transcriptional Activity for Acinetobacter junii Post Wastewater Treatment

Jumat

Haroon

Aljassim

et al. 2018

Water

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A membrane bioreactor (MBR)-based wastewater treatment plant (WWTP) in Saudi Arabia is assessed over a five-month period in 2015 and once in 2017 for bacterial diversity and transcriptional activity using metagenomics, metatranscriptomics and real time quantitative polymerase chain reaction (RT-qPCR). Acinetobacter spp. are shown to be enriched in the chlorinated effluent. Members of the Acinetobacter genus are the most abundant in the effluent and chlorinated effluent. At the species level, Acinetobacter junii have higher relative abundances post MBR and chlorination. RNA-seq analysis show that, in A. junii, 288 genes and 378 genes are significantly upregulated in the effluent and chlorinated effluent, respectively, with 98 genes being upregulated in both. RT-qPCR of samples in 2015 and 2017 confirm the upregulation observed in RNA-seq. Analysis of the 98 genes show that majority of the upregulated genes are involved in cellular repair and metabolism followed by resistance, virulence, and signaling. Additionally, two different subpopulations of A. junii are observed in the effluent and chlorinated effluent. The upregulation of cellular repair and metabolism genes, and the formation of different subpopulations of A. junii in both effluents provide insights into the mechanisms employed by A. junii to persist in the conditions of a WWTP.

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Bloodstream infection caused by Acinetobacter junii in a patient with acute lymphoblastic leukaemia after allogenic haematopoietic cell transplantation

Cited by 20 publications

References 16 publications

Molecular characterization and antimicrobial susceptibility of bacterial isolates present in tap water of public toilets

Molecular characterization and antimicrobial susceptibility of bacterial isolates present in tap water of public toilets

Mini Epidemic of Acinetobacter Junii in a Neonatal Intensive Care Unit: Risk Factors and Control Procedures

An Increase of Abundance and Transcriptional Activity for Acinetobacter junii Post Wastewater Treatment

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