Blueberry prevents bone loss in ovariectomized rat model of postmenopausal osteoporosis

Devareddy, Latha; Hooshmand, Shirin; Collins, John D.; Lucas, Edralin A.; Chai, Sheau C.; Arjmandi, Bahram H.

doi:10.1016/j.jnutbio.2007.09.004

Cited by 117 publications

(90 citation statements)

References 33 publications

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“…Both BMD and BMC levels are dramatically suppressed (p < 0.01) in the OVX rats than sham-operated control rats. Ample amount of researcher had already proved that the bone mass-BMD and BMC (Femur/Tibia or lumbar) were substantially reduced in estrogen deficiency OVX-induced animal model (Miao et al, 2014;Devareddy et al, 2008). Treatment for 13 weeks with VA 50 (p < 0.05) and 100 mg/kg (p < 0.01) in OVX rats considerably potentiated the levels of both BMC and BMD as compared to OVX rats.…”

Section: Resultsmentioning

confidence: 99%

Protective Effect of Vanillic Acid on Ovariectomy-Induced Osteoporosis in Rats

Wang¹,

Jiang²,

Gou³

2017

Afr J Tradit Complement Altern Med

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Background: The need for an anti-osteoporotic agent is in high demand since osteoporosis contributes to high rates of disability or impairment (high osteoporotic fracture), morbidity and mortality. Hence, the present study is designed to evaluate the protective effects of vanillic acid (VA) against bilateral ovariectomy-induced osteoporosis in female Sprague-Dawley (SD) rats. Materials and Methods: Forty healthy female adult SD rats were separated in to four groups with sham-operated control with bilateral laprotomy (Sham; n = 10), bilateral overiectomy (OVX; n = 10) group, OVX rats were orallay administrated with 50 mg/kg b.wt of VA (OVX + 50 VA; n = 10) or 100 mg/kg b.wt of VA (OVX + 100 VA; n = 10) for 12 weeks (post-treatment) after 4 weeks of OVX. Results: A significant change in the body weight gain was noted in OVX group, while treatment with VA substantially reverted to normalcy. Meanwhile, the bone mineral density and content (BMD and BMC) were substantially improved on supplementation with VA. Also, the bone turnover markers like calcium (Ca), phosphorous (P), osteocalcin (OC), alkaline phosphatase (ALP) and deoxypyridinoline (DPD) and inflammatory markers (IL-1β, IL-6, and TNF-α) levels were markedly attenuated in VA-treated rats. Moreover, the biomechanical stability was greatly ameliorated with VA administration. Both the dose of VA showed potent anti-osteoporotic activity, but VA 100 mg showed highest protective effects as compared with 50 mg of VA. Conclusion: Based on the outcome, we concluded that VA 100 showed better anti-osteoporotic activity by improving BMD and BMC as well as biomechanical stability and therefore used as an alternative therapy for treating postmenopausal osteoporosis.

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Section: Resultsmentioning

confidence: 99%

Protective Effect of Vanillic Acid on Ovariectomy-Induced Osteoporosis in Rats

Wang¹,

Jiang²,

Gou³

2017

Afr J Tradit Complement Altern Med

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“…In particular, as regards resveratrol, this increases bone mineral density and bone ALP in osteoporotic obese man (71), and represents an effective therapeutic agent in eliminating oxidative stress and in preventing bone loss in ovariectomized and old rats (72). Similarly, dietary supplementation with green tea or Hypericum perforatum or blueberry, containing various types of polyphenols, attenuates trabecular bone loss, prevents loss of collagen in bone matrix, inhibits senescence pathways in osteoblastic cells and prevents osteoporosis in ovariectomized rats (73)(74)(75)(76). Tea drinking is also associated with beneficial effects in maintaining bone density in old women and in menopausal women (77,78).…”

Section: Role Of Nutrients Containing Antioxidants In Treatment and Pmentioning

confidence: 99%

Oxidative stress in bone remodeling: role of antioxidants

Domazetovic

Marcucci

Iantomasi

et al. 2017

ccmbm

568

524

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SummaryROS are highly reactive molecules which consist of a number of diverse chemical species, including radical and non-radical oxygen species. Oxidative stress occurs as a result of an overproduction of ROS not balanced by an adequate level of antioxidants. The natural antioxidants are: thiol compounds among which GSH is the most representative, and non-thiol compounds such as polyphenols, vitamins and also various enzymes. Many diseases have been linked to oxidative stress including bone diseases among which one of the most important is the osteoporosis. The redox state changes are also related to the bone remodeling process which allows the continuous bone regeneration through the coordinated action of bone cells: osteoclasts, osteoblasts and osteocytes. Changes in ROS and/or antioxidant systems seem to be involved in the pathogenesis of bone loss. ROS induce the apoptosis of osteoblasts and osteocytes, and this favours osteoclastogenesis and inhibits the mineralization and osteogenesis. Excessive osteocyte apoptosis correlates with oxidative stress causing an imbalance in favor of osteoclastogenesis which leads to increased turnover of bone remodeling and bone loss. Antioxidants either directly or by counteracting the action of oxidants contribute to activate the differentiation of osteoblasts, mineralization process and the reduction of osteoclast activity. In fact, a marked decrease in plasma antioxidants was found in aged or osteoporotic women. Some evidence shows a link among nutrients, antioxidant intake and bone health. Recent data demonstrate the antioxidant properties of various nutrients and their influence on bone metabolism. Polyphenols and anthocyanins are the most abundant antioxidants in the diet, and nutritional approaches to antioxidant strategies, in animals or selected groups of patients with osteoporosis or inflammatory bone diseases, suggest the antioxidant use in anti-resorptive therapies for the treatment and prevention of bone loss.

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“…Devareddy et al (51) demonstrated that Ovx rats (6 months old) fed a diet supplemented with blueberry powder (5% w/w) for 4 months had a higher overall BMD of the whole body but not at the tibia, femur or fourth lumbar vertebra compared with rats in an Ovx group. Additionally, they identified that the supplement treatment down-regulated Ovx-induced elevation of alkaline phosphatase, collagen and tartrate-resistant acid phosphatase (TRAP) gene expression, suggesting that the bone-protective effect of blueberries may be due to the suppression of bone turnover (51). More recently, Zheng et al (52) identified that Ovx mice (14 weeks old) given a diet containing 1% anthocyanin-rich blackcurrant extract for 12 weeks had significantly greater femur BMD compared with Ovx control mice.…”

Section: Discussionmentioning

confidence: 99%

“…These other studies suggested that the effects of berry fruits or their extract on bone metabolism were more likely to be exerted through the suppression of bone resorption. Although previous in vivo studies (51,52) used mature Ovx rats, the rats used in the study by Zhang et al (56) were young Ovx rats in pre-pubertal growth stage. The ages of rats and the time after Ovx are important factors that may influence bone response following Ovx (39).…”

Section: Discussionmentioning

confidence: 99%

Effect of anthocyanin-rich bilberry extract on bone metabolism in ovariectomized rats

et al. 2017

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Abstract. Menopause is associated with increased oxidative stress, which serves a role, in part, in the pathogenesis of postmenopausal bone loss. Fruits and vegetables are rich in antioxidative nutrients and phytochemicals. Berries are a natural source of anthocyanins, and their intake may improve bone health. The aim of the present study was to determine the effect of an anthocyanin-rich bilberry extract (VME) on bone metabolism in an ovariectomized (Ovx) rat. Female Sprague-Dawley rats (12 weeks old) were randomly divided into the following four groups: Baseline, Sham, Ovx and Ovx+VME (n=8-12 rats per group). Rats in the Baseline group were sacrificed immediately, while those in the other groups were subjected to either sham operation (Sham) or bilateral Ovx (Ovx and Ovx+VME). Rats in the Ovx+VME group were administered VME daily at a dose of 500 mg/kg body weight. At 8 weeks after surgery, bone mass and bone histomorphometry were evaluated. The femur bone mineral density (BMD) in the Ovx group was significantly lower than that in the Sham group (P<0.01). Supplementation of VME in the Ovx rats did not result in an increase in BMD. Histomorphometric analyses revealed that Ovx resulted in decreased measures of bone volume and trabecular number and increased measures of osteoid volume, mineralizing surface and bone formation rates (all P<0.01), whereas VME had no significant effects on these parameters. The present findings indicate that VME did not alter bone metabolism in Ovx rats, suggesting that consumption of VME may not be helpful in preventing postmenopausal bone loss.

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Blueberry prevents bone loss in ovariectomized rat model of postmenopausal osteoporosis

Cited by 117 publications

References 33 publications

Protective Effect of Vanillic Acid on Ovariectomy-Induced Osteoporosis in Rats

Protective Effect of Vanillic Acid on Ovariectomy-Induced Osteoporosis in Rats

Oxidative stress in bone remodeling: role of antioxidants

Effect of anthocyanin-rich bilberry extract on bone metabolism in ovariectomized rats

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