BM‑MSCs protect against liver ischemia/reperfusion injury via HO‑1 mediated autophagy

Wang, Xun; Wang, Shuai; Zhou, Yuan; Obulkasim, Halmurat; Zhang, Zhi‐Heng; Dai, Bo; Zhu, Wei; Shi, Xiaolei

doi:10.3892/mmr.2018.9207

Cited by 12 publications

(15 citation statements)

References 62 publications

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“…IRI is one of the leading causes of the disability and death in patients after stroke, cerebral infarction, or organ transplantation. 21 It is usually associated with severe acute inflammation, such as systemic cytokine storm and substantial lymphocytes infiltration. 22,23 Thus, the development of anti-inflammation drugs for IRI treatment is of high priority.…”

Section: Discussionmentioning

confidence: 99%

“…However, the role of tranilast in neuronal systems remains poorly understood. IRI is one of the leading causes of the disability and death in patients after stroke, cerebral infarction, or organ transplantation . It is usually associated with severe acute inflammation, such as systemic cytokine storm and substantial lymphocytes infiltration .…”

Section: Discussionmentioning

confidence: 99%

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Tranilast Treatment Attenuates Cerebral Ischemia‐Reperfusion Injury in Rats Through the Inhibition of Inflammatory Responses Mediated by NF‐κB and PPARs

Yang

Zhuo

2018

Clinical Translational Sci

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Ischemia‐reperfusion injury ( IRI ) occurs when blood supply returns to tissue after interruption, which is associated with life‐threatening inflammatory response. Tranilast is a widely used antiallergic agent in the treatment against bronchial asthma and keloid. To study the function of tranilast, we used IRI in rat models. The brain tissues of IRI rats with or without tranilast treatment were collected. Neuronal apoptosis in the brain was detected by terminal deoxynucleotidyl transferase nick end labeling assay, and proinflammatory cytokine levels were measured by quantitative real‐time polymerase chain reaction and enzyme‐linked immunosorbent assay. The expression levels of nuclear factor‐kappa B ( NF ‐κB), inhibitor of κB (IκB) and peroxisome proliferator‐activated receptors ( PPAR s) were detected by Western blot. The results showed that tranilast treatment reduced neuronal apoptosis in the brain of IRI rats. Tranilast enhanced the short‐term memory and long‐term memory to novel object recognition paradigm. Tranilast treatment decreased the messenger RNA ( mRNA ) and protein levels of multiple proinflammatory cytokines, and affected NF ‐κB and inhibitor of kappa B protein expressions. Tranilast promoted the expressions of PPAR ‐α and PPAR ‐γ. Our findings demonstrate that tranilast treatment could attenuate cerebral IRI by regulating the inflammatory cytokine production and PPAR expression. Tranilast is a potential drug for IRI treatment in the clinic.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Tranilast Treatment Attenuates Cerebral Ischemia‐Reperfusion Injury in Rats Through the Inhibition of Inflammatory Responses Mediated by NF‐κB and PPARs

Yang

Zhuo

2018

Clinical Translational Sci

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“…Furthermore, MSCs have inhibitory effects on B-cell proliferation, differentiation, and antibody production [32]. Given that HO-1 has significant anti-inflammatory therapeutic potential, recent research has pointed out HO-1-modified MSCs have an enhanced ability to attenuate inflammatory responses in ischemic heart disease [33], acute ischemic liver failure [34], lipopolysaccharide (LPS)-induced microvascular injury [35], and cisplatin-induced AKI [36]. Taken together, the administration of MSCs prevents immune cell activation and modulates kidney inflammation progression by managing cytokine secretion to promote anti-inflammatory processes.…”

Section: Immune Responses and Inflammation In Ir-akimentioning

confidence: 99%

The Anti-Inflammatory, Anti-Oxidative, and Anti-Apoptotic Benefits of Stem Cells in Acute Ischemic Kidney Injury

Lee

Tseng

Yang

et al. 2019

IJMS

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Ischemia-reperfusion injury (IRI) plays a significant role in the pathogenesis of acute kidney injury (AKI). The complicated interaction between injured tubular cells, activated endothelial cells, and the immune system leads to oxidative stress and systemic inflammation, thereby exacerbating the apoptosis of renal tubular cells and impeding the process of tissue repair. Stem cell therapy is an innovative approach to ameliorate IRI due to its antioxidative, immunomodulatory, and anti-apoptotic properties. Therefore, it is crucial to understand the biological effects and mechanisms of action of stem cell therapy in the context of acute ischemic AKI to improve its therapeutic benefits. The recent finding that treatment with conditioned medium (CM) derived from stem cells is likely an effective alternative to conventional stem cell transplantation increases the potential for future therapeutic uses of stem cell therapy. In this review, we discuss the recent findings regarding stem cell-mediated cytoprotection, with a focus on the anti-inflammatory effects via suppression of oxidative stress and uncompromised immune responses following AKI. Stem cell-derived CM represents a favorable approach to stem cell-based therapy and may serve as a potential therapeutic strategy against acute ischemic AKI.

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“…The regenerative potential of MSCs‐Exo has been reported in various age‐related degenerative diseases 56,57 . MSCs‐Exo exhibited regenerative properties on bone and cartilage degradation in OA 58,59 and in diabetes, 60 in pancreatic diseases, 61 in lung and liver injury, 62,63 in retinal degenerative diseases, 64 in renal failure, 65 in CVDs, 66 or stroke 67 . The effects of exosomes on the ageing process have been studied in vivo.…”

Section: Distinct Effect Of Mscs‐exo On Ageingmentioning

confidence: 99%

Ageing and mesenchymal stem cells derived exosomes: Molecular insight and challenges

Ahmadi

Rezaie

2020

Cell Biochemistry & Function

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Ageing induces a great risk factor that participates in progressing various degenerative diseases morbidities. The main characteristic of ageing is the failure in maintaining homeostasis in the organs with a cellular senescence. Senescence is characterized by reduced cell growth, evade cellular death, and acquiring a senescence‐associated secretory phenotype (SASP). Mesenchymal stem cells (MSCs) are advantageous cells in regenerative medicine, exerting pleiotropic functions by producing soluble factors, such as exosomes. MSCs and their exosomes (MSCs‐Exo) kinetic are affected by ageing and other aged exosomes. Exosomes biogenesis from aged MSCs is accelerated and their exosomal cargoes, such as miRNAs, vary as compared to those of normal cells. Besides, exosomes from aged MSCs loss their regenerative potential and may negatively influence the function of recipient cells. MSCs‐Exo can improve ageing and age‐related diseases; however, the detailed mechanisms remain yet elusive. Although exosomes‐therapy may serve as a new approach to combat ageing, the translation of preclinical results to clinic needs more extensive investigation on exosomes both on their biology and related techniques. Overall, scrutiny on the effect of ageing on MSCs and vice versa is vital for designing novel therapy using MSCs with focus on the management of older individuals.

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BM‑MSCs protect against liver ischemia/reperfusion injury via HO‑1 mediated autophagy

Cited by 12 publications

References 62 publications

Tranilast Treatment Attenuates Cerebral Ischemia‐Reperfusion Injury in Rats Through the Inhibition of Inflammatory Responses Mediated by NF‐κB and PPARs

Tranilast Treatment Attenuates Cerebral Ischemia‐Reperfusion Injury in Rats Through the Inhibition of Inflammatory Responses Mediated by NF‐κB and PPARs

The Anti-Inflammatory, Anti-Oxidative, and Anti-Apoptotic Benefits of Stem Cells in Acute Ischemic Kidney Injury

Ageing and mesenchymal stem cells derived exosomes: Molecular insight and challenges

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