Bmpr1a Signaling in Cartilage Development and Endochondral Bone Formation

Jing, Junjun; Hinton, Robert J.; Feng, Jian Q.

doi:10.1016/bs.vh.2015.06.001

Cited by 23 publications

(15 citation statements)

References 67 publications

(64 reference statements)

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“… 51 The regulatory function of ALK3 in chondrogenesis has been further supported by in vivo studies. 81–86 Initially, the role of ALK3 in chondrogenesis, such as regulating chondrocyte proliferation, survival, and differentiation, was thought to be associated with ALK6 during chondrogenesis. 81 Soon after, it was demonstrated that ALK3 itself has a unique and broad role during chondrogenesis.…”

Section: Biological Functions Of Alk3 In Bone Formationmentioning

confidence: 99%

The biological function of type I receptors of bone morphogenetic protein in bone

Svoboda

Feng

et al. 2016

Bone Res

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Bone morphogenetic proteins (BMPs) have multiple roles in skeletal development, homeostasis and regeneration. BMPs signal via type I and type II serine/threonine kinase receptors (BMPRI and BMPRII). In recent decades, genetic studies in humans and mice have demonstrated that perturbations in BMP signaling via BMPRI resulted in various diseases in bone, cartilage, and muscles. In this review, we focus on all three types of BMPRI, which consist of activin-like kinase 2 (ALK2, also called type IA activin receptor), activin-like kinase 3 (ALK3, also called BMPRIA), and activin-like kinase 6 (ALK6, also called BMPRIB). The research areas covered include the current progress regarding the roles of these receptors during myogenesis, chondrogenesis, and osteogenesis. Understanding the physiological and pathological functions of these receptors at the cellular and molecular levels will advance drug development and tissue regeneration for treating musculoskeletal diseases and bone defects in the future.

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Section: Biological Functions Of Alk3 In Bone Formationmentioning

confidence: 99%

The biological function of type I receptors of bone morphogenetic protein in bone

Svoboda

Feng

et al. 2016

Bone Res

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“…Noggin expression is highly related to patent sutures (Warren et al, 2003), and improper Noggin expression can prevent cranial suture fusion (Warren et al, 2003). BMPRIA mutations in osteoclasts, osteoblasts, or cartilage result in defective bone remodeling or growth (Mishina et al, 2004;Kamiya et al, 2008;Okamoto et al, 2011;Jing et al, 2013Jing et al, , 2015, and constitutively activated BMPRIA in neuralcrest cells results in craniosynostosis (Komatsu et al, 2013). BMP2 is ectopically expressed in Gli3 mutant mesenchyme, which can lead to abnormal osteoblasts differentiation (Tanimoto et al, 2012).…”

Section: Bmp Signaling In Adult Calvarial Stem-cell Nichementioning

confidence: 99%

BMP Signaling in the Development and Regeneration of Cranium Bones and Maintenance of Calvarial Stem Cells

Chen

Yao

et al. 2020

Front. Cell Dev. Biol.

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The bone morphogenetic protein (BMP) signaling pathway is highly conserved across many species, and its importance for the patterning of the skeletal system has been demonstrated. A disrupted BMP signaling pathway results in severe skeletal defects. Murine calvaria has been identified to have dual-tissue lineages, namely, the cranial neural-crest cells and the paraxial mesoderm. Modulations of the BMP signaling pathway have been demonstrated to be significant in determining calvarial osteogenic potentials and ossification in vitro and in vivo. More importantly, the BMP signaling pathway plays a role in the maintenance of the homeostasis of the calvarial stem cells, indicating a potential clinic significance in calvarial bone and in expediting regeneration. Following the inherent evidence of BMP signaling in craniofacial biology, we summarize recent discoveries relating to BMP signaling in the development of calvarial structures, functions of the suture stem cells and their niche and regeneration. This review will not only provide a better understanding of BMP signaling in cranial biology, but also exhibit the molecular targets of BMP signaling that possess clinical potential for tissue regeneration.

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“…Tiene la capacidad de inducir la formación de hueso; cartílagos y tejido conjuntivo 54 . En un estudio realizado por Jing et al 54 concluyeron que las proteínas morfogenéticas son críticas para el desarrollo y crecimiento del cóndilo mandibular a través de su efecto sobre la proliferación de precondroblastos y la diferenciación de condrocitos. Su función condrogénica es inhibida por Wnt dependiente de β Catenina durante la condensación del mesénquima 55 .…”

Section: Tablaunclassified

Crecimiento del cartílago condilar. Una revisión de la literatura

Peláez

Murillo

Parada

2018

Odontol. sanmarquina

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El cóndilo mandibular es un cartílago secundario caracterizado por su respuesta a cargas funcionales y mecánicas. Su estimulación repetida desencadena una serie de eventos que parecen aumentar el número de células mesenquimales de replicación. En esta revisión de la literatura se presentan los hallazgos fundamentales para comprender los factores que condicionan el crecimiento condilar. Se analizaron los siguientes tópicos asociados: embriología, influencia genética y ambiental, función como centro de crecimiento y la bioingeniería aplicada a este campo. Se evidenció en la literatura revisada que el cóndilo actúa como principal centro de crecimiento adaptativo regional y que la regulación del desarrollo está determinada por factores genéticos y epigenéticos que modifican la expresión de factores de transcripción y crecimiento.

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Bmpr1a Signaling in Cartilage Development and Endochondral Bone Formation

Cited by 23 publications

References 67 publications

The biological function of type I receptors of bone morphogenetic protein in bone

The biological function of type I receptors of bone morphogenetic protein in bone

BMP Signaling in the Development and Regeneration of Cranium Bones and Maintenance of Calvarial Stem Cells

Crecimiento del cartílago condilar. Una revisión de la literatura

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