Body and Serum Potassium in Liver Disease

Casey, Thomas H.; Summerskill, W.H.J.; Orvis, Alan L.

doi:10.1016/s0016-5085(65)80138-x

Cited by 55 publications

(6 citation statements)

References 14 publications

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“…Studies have shown that patients with chronic liver dysfunction have abnormal K þ balance (4,7,(16)(17)(18). This had been attributed to poor dietary intake, urinary and gastrointestinal losses, and effects of chronic illness.…”

Section: Discussionmentioning

confidence: 99%

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Urinary Potassium Loss in Children With Acute Liver Failure and Acute Viral Hepatitis

Bhatia

Dhawan²,

Arora³

et al. 2013

J. pediatr. gastroenterol. nutr.

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Section: Discussionmentioning

confidence: 99%

“…The patients with cirrhosis of the liver may have a deficit of up to 30% to 40% of total body K + (4,5). Children with chronic liver disease can present with hypokalemia, hyperkalemia, or normokalemia (6).…”

mentioning

confidence: 99%

Urinary Potassium Loss in Children With Acute Liver Failure and Acute Viral Hepatitis

Bhatia

Dhawan²,

Arora³

et al. 2013

J. pediatr. gastroenterol. nutr.

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“…At the same time, there is a 30% to 40% decrease of the total body potassium in patients with liver disease. 15 16 Hypokalemia could precipitate hepatic encephalopathy because of increased ammoniagenesis. 17 Hypokalemia happens mainly due to intracellular shift of potassium and non-potassium sparing diuretic use.…”

Section: Electrolytes and Water Disturbancementioning

confidence: 99%

Renal Dysfunction in Patients with Liver Cirrhosis

Sobh

Abdalbary

Abdelsalam

et al. 2022

Digestive Disease Interventions

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Liver cirrhosis is a major health problem that can affect people of different ages. It induces pivotal hemodynamic and metabolic systemic disturbances along with other organs dysfunction. Renal dysfunction in cirrhotic patients is not uncommon, and subtle renal impairment is an early and very frequent finding. Liver cirrhosis can afflict kidney functions through different mechanisms. Renal vasoconstriction is usually the initial response of splanchnic vasodilation and decreased effective renal plasma flow. This induces a reduction of intraglomerular pressure leading to stimulation of renin-angiotensin system to maintain the glomerular filtration rate. Other causes of renal dysfunction include electrolytes and acid-base disturbances, systemic inflammation, bile cast nephropathy, and intra-abdominal hypertension. Loss of renal reserve is usually the earliest manifestation of kidney dysfunction in cirrhotic patients. This makes the kidney supersensitive to any subsequent hemodynamic or metabolic abnormalities. Proper assessment of kidney function is one of the major challenges in cirrhotic patients. The use of serum creatinine and creatinine-based equations is inaccurate and can overestimate kidney function. Hepato-renal syndrome (HRS) is a life-threatening disorder. In the last decade, there was significant progress in understanding the mechanism of this mysterious disorder. In this article, we are focusing on different mechanisms of kidney dysfunction in cirrhotic patients and the major diagnostic and therapeutic challenges.

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“…Decreased hepatic inactivation of aldosterone has also been found in cirrhotics (Coppage et al, 1962). These factors cause increased effective aldosterone levels and often lead to sodium retention and appreciable potassium depletion (de Deuxchaisnes et al, 1961;Casey et al, 1965). Further potassium depletion occurs if thiazides or more potent natriuretic agents are given, as these drugs increase the amount of sodium presented to the distal tubule where increased aldosterone levels facilitate the exchange of sodium for potassium; severe electrolyte disturbances may result and may be related to the development of hepatic encephalopathy (Lieberman and Reynolds, 1965;Sherlock et al, 1966).…”

Section: Introductionmentioning

confidence: 99%

Spironolactone Diuresis in Patients with Cirrhosis and Ascites

Eggert¹

1970

BMJ

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Body and Serum Potassium in Liver Disease

Cited by 55 publications

References 14 publications

Urinary Potassium Loss in Children With Acute Liver Failure and Acute Viral Hepatitis

Urinary Potassium Loss in Children With Acute Liver Failure and Acute Viral Hepatitis

Renal Dysfunction in Patients with Liver Cirrhosis

Spironolactone Diuresis in Patients with Cirrhosis and Ascites

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