Body Composition and Muscular Strength Changes After Moderate Activity: Association With Matrix Metalloproteinase Polymorphisms

Fiotti, Nicola; Deiuri, E.; Altamura, Nicola; Colle, Paolo De; Moretti, Michèle; Toigo, G.; Giansante, Carlo

doi:10.1016/j.archger.2009.09.016

Cited by 11 publications

(7 citation statements)

References 25 publications

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“…In this study, correlation between MMP-9 and body composition parameters occurred, particularly with BFP and SMM. This interesting finding was supported by a previous study that reported a negative correlation between MMP-9 and obesity ( 53 , 54 ) and muscle strength ( 55 ).…”

Section: Discussionsupporting

confidence: 83%

Ramadan Fasting in Germany (17–18 h/Day): Effect on Cortisol and Brain-Derived Neurotrophic Factor in Association With Mood and Body Composition Parameters

et al. 2021

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Ramadan fasting (RF) is a type of diurnal intermittent fasting. Previous studies reported the benefits of RF in healthy subjects on mood and health related to quality of life (QoL). Cortisol and brain-derived neurotrophic factor (BDNF) have been shown to play a role in mood, body composition parameters, and health-related QoL. This study aimed at elucidating the mechanism of the benefit of RF, particularly cortisol and BNDF and their association with mood and QoL. Insulin growth factor-1 (IGF-1), interleukin (IL)-8, matrix metalloproteinase (MMP)-9, and myoglobin were determined. Thirty-four healthy men and women were recruited. Serum from peripheral venous blood samples was collected at five time points: 1 week before RF (T1); mid of RF (T2), last days of RF (T3), 1 week after RF (T4), and 1 month after RF (T5). The amounts of biological mediators in the serum samples were determined by enzyme-linked immunosorbent assay (ELISA) and Luminex assays. BDNF and cortisol significantly decreased at T3 (p < 0.05) and T4 (p < 0.001) compared to T1, respectively. It seems the benefits of RF for mood-related symptoms are mediated by different biological mediators, particularly cortisol and BDNF.

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Section: Discussionsupporting

confidence: 83%

Ramadan Fasting in Germany (17–18 h/Day): Effect on Cortisol and Brain-Derived Neurotrophic Factor in Association With Mood and Body Composition Parameters

et al. 2021

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“…In a study conducted with 177 healthy men, the allele frequencies were determined as 90% for the C allele and 10% for the T allele, similar to the present study and plasma pro-MMP9 levels had no signi cant differences among MMP9 -1562 C/T polymorphism genotype groups in healthy men [28]. Fiotti, Deiuri [29] found that body composition and strength parameters improved after long-term physical exercise applied to elderly women, and these improvements were associated with certain MMP polymorphisms, including MMP9. In the current study, the increase in AST level response to Yo-Yo IR1 was higher in athletes with the CT genotype than in sedentary individuals with the CT genotype.…”

Section: Discussionsupporting

confidence: 81%

The Effect of Maximal Exercise on Matrix Metalloproteinase, its Inhibitor (MMP9 and TIMP1), and the Role of MMP9 -1562 C/T and TIMP1 372 T/C Polymorphisms

Kosova

Turgay

Yigittürk

et al. 2021

Preprint

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To investigate the levels of MMP9 and TIMP1 before and after acute maximal exercise and the role of MMP9 -1562 C/T and TIMP1 372 T/C polymorphisms in athletes and sedentary individuals. The athlete group (n = 43) and sedentary group (n = 43) performed the Yo-Yo intermittent recovery test level 1. A blood sample was taken before and after the test. MMP9, TIMP1, MMP9/TIMP1 ratio, blood lipids, and lipoproteins (total cholesterol, high and low-density lipoprotein cholesterol) and indicators of muscle damage (creatine kinase, aspartate aminotransferase, alanine aminotransferase) were determined from postprandial venous blood samples. Genetic polymorphisms were determined from DNA samples obtained from peripheral blood. MMP9 levels were found higher in both groups after the YOYO IR-1 test (exercise) (sedentary group, pre-exercise: 1771.15 ± 862.17 pg/mL, post-exercise: 2172.18 ± 680.93 pg/mL; athletic group, pre-exercise: 1373.57 ± 705.16 pg/mL, post-exercise: 1723.72 ± 733.88 pg/mL, p < 0.05). TIMP1 levels were also found higher in both groups after exercise (sedentary group, pre-exercise: 4.63 ± 3.99 ng/mL, post-exercise: 5.3 ± 3.51 ng/mL; athletic group, pre-exercise: 3.26 ± 2.34 ng/mL, post-exercise: 3.59 ± 1.99 ng/mL, p < 0.05). Basal serum MMP9 levels were significantly higher in sedentary individuals as compared with athletes (p = 0.046). MMP9 -1562 C/T and TIMP1 372 T/C polymorphisms had no effect on MMP9 and TIMP1 levels (p > 0.05). As a conclusion acute exercise increases MMP9 and TIMP1 levels in male athletes and sedentary individuals. Chronic anaerobic exercises performed by the athletic group may caused lower MMP9 levels. MMP9 -1562 C/T and TIMP1 372 T/C genetic polymorphisms are not associated with MMP9 and TIMP1 activation.

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“…The effect of training on gelatinase plasma or serum concentrations was studied in old sedentary women, [ 38 ] in men with MS factors, [ 39 ] in subjects with asymptomatic coronary artery disease or cardiovascular risk factors [ 40 ] and in patients with type 2 diabetes mellitus. [ 41 ] In these studies training consisted in walking or running, except for elderly women, [ 38 ] who performed exercises aiming at increasing synchronization, dexterity, flexibility, strength, and steadiness. The training programs considerably differed in the frequency and intensity of exercise, as well as in the overall duration, ranging from 3 to 24 weeks.…”

Section: Resultsmentioning

confidence: 99%

Gelatinases and physical exercise

Presti¹,

Hopps

Caimi

2017

Medicine

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Background:Matrix metalloproteinases (MMPs), particularly gelatinase A (MMP-2) and gelatinase B (MMP-9), as well as their tissue inhibitors (TIMP-1 and TIMP-2), are involved in the development of skeletal muscle tissue, in the repair process after muscle injury and in the adaptive modifications induced by physical exercise in skeletal muscle. This paper aims at reviewing results from human studies that investigated the role of gelatinases and their inhibitors in skeletal muscle response to acute physical exercise or training.Methods:Electronic databases PubMed/MEDLINE, Scopus and Web of Science were searched for papers published between January 2000 and February 2017. The papers were eligible when reporting human studies in which MMP-2 and/or MMP-9 and/or the inhibitors TIMP-1/TIMP-2 were evaluated, in blood or muscular tissue, before and after acute physical exercise or before and after a period of structured physical training. We included studies on healthy subjects and patients with chronic metabolic diseases (obesity, diabetes mellitus, metabolic syndrome—MS) or asymptomatic coronary artery disease. We excluded studies on patients with neurological, rheumatologic or neoplastic diseases.Results:Studies conducted on muscle biopsies showed an early stimulation of MMP-9 gene transcription as a result of acute exercise, whereas MMP-2 and TIMP transcription resulted from regular repetition of exercise over time. Studies on serum or plasma level of gelatinases and their inhibitors showed an early release of MMP-9 after acute exercise of sufficient intensity, while data on MMP-2 and TIMP were more contrasting. Most of the studies dealing with the effect of training indicated a trend toward reduction in blood gelatinase levels, once again more clear for MMP-9. This result was related to an anti-inflammatory effect of regular exercise and was more evident when training consisted of aerobic activities. This study has limitations: as the initial selection was done through titles and abstracts, incomplete retrieval cannot be excluded, as well as we cannot exclude bias due to selective reporting within studies.Conclusion:A better knowledge of the molecular events activated by different types of acute exercise and regular training could be of great relevance in order to maximize the benefits of physical activity in healthy subjects and patients.

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Body Composition and Muscular Strength Changes After Moderate Activity: Association With Matrix Metalloproteinase Polymorphisms

Cited by 11 publications

References 25 publications

Ramadan Fasting in Germany (17–18 h/Day): Effect on Cortisol and Brain-Derived Neurotrophic Factor in Association With Mood and Body Composition Parameters

Ramadan Fasting in Germany (17–18 h/Day): Effect on Cortisol and Brain-Derived Neurotrophic Factor in Association With Mood and Body Composition Parameters

The Effect of Maximal Exercise on Matrix Metalloproteinase, its Inhibitor (MMP9 and TIMP1), and the Role of MMP9 -1562 C/T and TIMP1 372 T/C Polymorphisms

Gelatinases and physical exercise

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