Body Lipids of Guinea Pigs Exposed to Different Dietary Fats from Mid-Gestation to 3 Months of Age

Kirtland, Janet; De, Pavey

doi:10.1159/000176491

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Details of animals and diets have been given by Kirtland et al (5) and Pavey et al (7). The commercial diet contained 3.5% of fat compared to 22% of fat in the diets with added fat.…”

Section: Animals and Dietsmentioning

confidence: 99%

Body Lipids of Guinea Pigs Exposed to Different Dietary Fats from Mid-Gestation to 3 Months of Age

Pavey

Widdowson²

1980

Ann Nutr Metab

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Pregnant guinea pigs were fed on one of three diets: a commercial low-fat diet or a high-fat diet containing either maize oil or beef dripping. The young were killed at birth, the brain removed and dissected into three regions; the cerebellum, cerebrum and stem. The fatty acid composition of the major phospholipid classes, phosphatidylcholine and phosphatidylethanolamine was determined using gas chromatography. Compared with those fed the commercial or beef dripping diet the brain of the young of mothers fed maize oil during pregnancy had an increased percentage of linoleic acid and of its long-chain derivatives arachidonic acid and docosapentaenoic acid and a lower percentage of docosahexaenoic acid. These changes occurred in both lipid classes and in all regions of the brain. The results demonstrate that the fatty acid composition of the brain lipids of newborn guinea pigs can be influenced by the nature of the maternal dietary fat consumed during the last weeks of pregnancy.

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“…Details of animals and diets have been given by Kirtland et al (5) and Pavey et al (7). The commercial diet contained 3.5% of fat compared to 22% of fat in the diets with added fat.…”

Section: Animals and Dietsmentioning

confidence: 99%

Body Lipids of Guinea Pigs Exposed to Different Dietary Fats from Mid-Gestation to 3 Months of Age

Pavey

Widdowson²

1980

Ann Nutr Metab

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Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic

Morrison

Botting

Darby

et al. 2018

The Journal of Physiology

125

108

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Over 30 years ago Professor David Barker first proposed the theory that events in early life could explain an individual's risk of non-communicable disease in later life: the developmental origins of health and disease (DOHaD) hypothesis. During the 1990s the validity of the DOHaD hypothesis was extensively tested in a number of human populations and the mechanisms underpinning it characterised in a range of experimental animal models. Over the past decade, researchers have sought to use this mechanistic understanding of DOHaD to develop therapeutic interventions during pregnancy and early life to improve adult health. A variety of animal models have been used to develop and evaluate interventions, each with strengths and limitations. It is becoming apparent that effective translational research requires that the animal paradigm selected mirrors the tempo of human fetal growth and development as closely as possible so that the effect of a perinatal insult and/or therapeutic intervention can be fully assessed. The guinea pig is one such animal model that over the past two decades has demonstrated itself to be a very useful platform for these important reproductive studies. This review highlights similarities in the in utero development between humans and guinea pigs, the strengths and limitations of the guinea pig as an experimental model of DOHaD and the guinea pig's potential to enhance clinical therapeutic innovation to improve human health.

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Body Lipids of Guinea Pigs Exposed to Different Dietary Fats from Mid-Gestation to 3 Months of Age

Cited by 2 publications

References 10 publications

Body Lipids of Guinea Pigs Exposed to Different Dietary Fats from Mid-Gestation to 3 Months of Age

Body Lipids of Guinea Pigs Exposed to Different Dietary Fats from Mid-Gestation to 3 Months of Age

Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic

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