Body temperatures of house mice artificially selected for high voluntary wheel-running behavior: repeatability and effect of genetic selection

Rhodes, Justin S.; Koteja, Paweł; Swallow, John G.; Carter, P. A.; Garland, Theodore

doi:10.1016/s0306-4565(99)00112-6

Cited by 52 publications

(43 citation statements)

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“…No differences in body temperatures were observed between control and selected mice at any of the ambient temperatures measured, which is in agreement with previous measurements of body temperature in mice of the same strain at an ambient temperature of 22°C (Rhodes et al 2000). Regulation of body temperature at rest thus appears unchanged in mice selected for high wheel-running activity and there does not appear to be a difference in thermoregulatory capacity, at least at the temperatures studied here.…”

Section: Discussionsupporting

confidence: 92%

Wheel-running activity and energy metabolism in relation to ambient temperature in mice selected for high wheel-running activity

et al. 2006

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Wheel-running activity and energy metabolism in relation to ambient temperature in mice selected for high wheel-running activity Vaanholt, Lobke M.; Garland, Theodore; Daan, Serge; Visser, G. Henk; Garland Jr., Theodore; Heldmaier, G. Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 12-05-2018Abstract Interrelationships between ambient temperature, activity, and energy metabolism were explored in mice that had been selectively bred for high spontaneous wheel-running activity and their randombred controls. Animals were exposed to three different ambient temperatures (10, 20 and 30°C) and wheelrunning activity and metabolic rate were measured simultaneously. Wheel-running activity was decreased at low ambient temperatures in all animals and was increased in selected animals compared to controls at 20 and 30°C. Resting metabolic rate (RMR) and daily energy expenditure (DEE) decreased with increasing ambient temperature. RMR did not differ between control and selected mice, but mass-specific DEE was increased in selected mice. The cost of activity (measured as the slope of the relationship between metabolic rate and running speed) was similar at all ambient temperatures and in control and selected mice. Heat generated by running apparently did not substitute for heat necessary for thermoregulation. The overall estimate of running costs was 1.2 kJ/km for control mice and selected mice.

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Section: Discussionsupporting

confidence: 92%

Wheel-running activity and energy metabolism in relation to ambient temperature in mice selected for high wheel-running activity

et al. 2006

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“…This was caused primarily by S mice running faster rather than for more minutes each day, but the relative importance of the two components differs between the sexes, with females from the S lines typically showing little or no increase in amount of time running whereas males do show an increase in time running (Swallow et al, 1998a;Koteja et al, 1999a;Koteja et al, 1999b;Rhodes et al, 2000;Girard et al, 2001). This increase in wheel running greatly exceeds that of wild house mice born and raised under the same conditions (Dohm et al, 1994), and comes close to spanning the range of variation that has been reported among 13 species of wild murid rodents .…”

Section: Selective Breeding For High Voluntary Wheel Running Inmentioning

confidence: 99%

Phenotypic plasticity and experimental evolution

Garland

Kelly

2006

Journal of Experimental Biology

273

140

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There were two errors published in J. Exp. Biol. 209, 2344-2361 First, on p. 2355 in the first complete paragraph of the section entitled 'Plasticity of exercise-related traits', the authors stated:If we imagine further that S and C mice housed without wheels showed no difference (or at least values similar to those of C mice housed with wheels), then the S mice seem to be more responsive to wheel exposure, i.e. they are more plastic.The sentence should have read:If we imagine further that S and C mice housed without wheels showed values similar to those of C mice housed with wheels, then the S mice seem to be more responsive to wheel exposure, i.e. they are more plastic.Second, on pp. 2355-2356, beginning in column 2 of p. 2355, the authors stated:For hematocrit in females, Table·2 shows that the ln likelihood of the nested ANCOVA model without wheel running (-75.7) is larger (less negative, in this case) than for the model with wheel running (-83.7). As the latter model contains one additional parameter (estimating the effect of wheel running), twice the difference in ln likelihoods (16.0, in this case) can be compared with a χ 2 distribution with one degree of freedom, for which the critical value for P=0.05 is 3.841. Therefore, the model with wheel running as an additional covariate yields a significantly worse fit to the data, and we conclude that the difference in hematocrit between S and C mice when housed with wheel access is not best explained as a simple function of the greater running by S mice.The paragraph should have read:For hematocrit in females, Table·2 shows that the ln likelihood of the nested ANCOVA model without wheel running is -78.1 whereas for the model with wheel running it is -77.9. As the latter model contains one additional parameter (estimating the effect of wheel running), twice the difference in ln likelihoods (0.3 in this case) can be compared with a χ 2 distribution with one degree of freedom, for which the critical value for P=0.05 is 3.841. Therefore, the model with wheel running as an additional covariate does not fit the data significantly better, and we conclude that the difference in hematocrit between S and C mice when housed with wheel access is not best explained as a simple function of the greater running by S mice.We apologise to the authors and readers for these errors but do not believe that they compromise the overall results and conclusions of the paper. Erratum 2344Introduction Natural selection tends to act most strongly on aspects of the phenotype (traits) at relatively high levels of biological organization because they are the most strongly correlated with Darwinian fitness (e.g. lifetime reproductive success). Components of life history, behaviors and aspects of organismal performance (for reviews, see Ketterson and Nolan, Jr, 1999;Irschick and Garland, Jr, 2001;Kingsolver and Huey, 2003;Costa and Sinervo, 2004) are 'complex traits' in that they are composed of many subordinate traits at lower levels of biological organization (Fig.·1). Thus, the evolutiona...

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“…On a daily basis, mice from the selected (S) lines run 2.5-to 3.0-fold farther than control mice, and the increased distance is mainly accomplished by higher running speeds Rhodes et al, 2000;Girard et al, 2001;Rezende et al, 2005;Rezende et al, 2009). As a group, the four replicate selected lines show a diverse suite of morphological, biochemical, physiological, and behavioural differences from the four non-selected control lines (e.g.…”

Section: Introductionmentioning

confidence: 99%

Locomotor trade-offs in mice selectively bred for high voluntary wheel running

Dlugosz

Chappell

McGillivray

et al. 2009

Journal of Experimental Biology

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SUMMARYWe investigated sprint performance and running economy of a unique 'mini-muscle' phenotype that evolved in response to selection for high voluntary wheel running in laboratory mice (Mus domesticus). Mice from four replicate selected (S) lines run nearly three times as far per day as four control lines. The mini-muscle phenotype, resulting from an initially rare autosomal recessive allele, has been favoured by the selection protocol, becoming fixed in one of the two S lines in which it occurred. In homozygotes, hindlimb muscle mass is halved, mass-specific muscle oxidative capacity is doubled, and the medial gastrocnemius exhibits about half the mass-specific isotonic power, less than half the mass-specific cyclic work and power, but doubled fatigue resistance. We hypothesized that mini-muscle mice would have a lower whole-animal energy cost of transport (COT), resulting from lower costs of cycling their lighter limbs, and reduced sprint speed, from reduced maximal force production. We measured sprint speed on a racetrack and slopes (incremental COT, or iCOT) and intercepts of the metabolic rate versus speed relationship during voluntary wheel running in 10 mini-muscle and 20 normal S-line females. Mini-muscle mice ran faster and farther on wheels, but for less time per day. Mini-muscle mice had significantly lower sprint speeds, indicating a functional trade-off. However, contrary to predictions, mini-muscle mice had higher COT, mainly because of higher zero-speed intercepts and postural costs (intercept-resting metabolic rate). Thus, mice with altered limb morphology after intense selection for running long distances do not necessarily run more economically.

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Body temperatures of house mice artificially selected for high voluntary wheel-running behavior: repeatability and effect of genetic selection

Cited by 52 publications

References 38 publications

Wheel-running activity and energy metabolism in relation to ambient temperature in mice selected for high wheel-running activity

Wheel-running activity and energy metabolism in relation to ambient temperature in mice selected for high wheel-running activity

Phenotypic plasticity and experimental evolution

Locomotor trade-offs in mice selectively bred for high voluntary wheel running

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