Body Topography Parcellates Human Sensory and Motor Cortex

Kuehn, Esther; Dinse, Juliane; Jakobsen, Estrid; Long, Xiangyu; Schäfer, Andreas; Bazin, Pierre-Louis; Villringer, Arno; Sereno, Martin I.; Margulies, Daniel S.

doi:10.1093/cercor/bhx026

Cited by 71 publications

(138 citation statements)

References 96 publications

(144 reference statements)

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“…task-related functional activity in unimodal cortical areas, including the visual (65,66), auditory (67,68), and sensorimotor cortex (46,69). This close link between functional properties and regional myelin content provides a good explanation for the structure-function relationship found in this study.…”

Section: Discussionsupporting

confidence: 66%

Multimodal finger-printing of the human precentral cortex forming the motor hand knob

Dubbioso

Madsen

Thielscher

et al. 2020

Preprint

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Transcranial magnetic stimulation (TMS) of the precentral hand knob can evoke motor evoked potentials (MEP) in contralateral hand muscles. Biophysical modelling points to the dorsal premotor cortex (PMd) in the superficial crown-lip region as primary site of TMS-induced neuronal excitation. Here, we used a sulcusaligned MRI-informed TMS mapping approach to determine the optimal site (hotspot) for evoking MEPs in the precentral hand knob. Individual precentral hotspot location varied along the rostro-caudal axis. Individuals with a more rostral location had longer MEP latencies. Spatiotemporal "hotspot rostrality" was associated with higher precentral myelin-related signals, stronger movement-related activation of PMd in the precentral crown, and higher temporal precision during paced finger tapping. Together, our multimodal mapping approach provides first-time evidence for behaviourally relevant, structural and functional phenotypic variation in the crown of human precentral motor hand knob. The results have important implications for physiological and interventional TMS studies targeting the precentral hand knob.

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Section: Discussionsupporting

confidence: 66%

Multimodal finger-printing of the human precentral cortex forming the motor hand knob

Dubbioso

Madsen

Thielscher

et al. 2020

Preprint

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“…7b). The shared and relatively steep anterolateral and medial gradients in putative myelination and degree of frequency specificity -observed in two independently-acquired datasets -suggests a shared functional and myeloarchitectonic border, possibly similar in character to those reported recently relating resting state, standard task activation, and T1/T2derived myelination estimates across cortex (Glasser et al, 2016;Kuehn et al, 2017).…”

Section: Comparison Of Response Profiles To All Frequency Bands Acrossupporting

confidence: 73%

Extensive tonotopic mapping across auditory cortex is recapitulated by spectrally-directed attention, and systematically related to cortical myeloarchitecture

Dick

Lehet

Callaghan

et al. 2017

Preprint

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Auditory selective attention is vital in natural soundscapes. But, it is unclear how attentional focus on the primary dimension of auditory representation -acoustic frequency -might modulate basic auditory functional topography during active listening. In contrast to visual selective attention, which is supported by motor-mediated optimization of input across saccades and pupil dilation, the primate auditory system has fewer means of differentially sampling the world. This makes spectrally-directed endogenous attention a particularly crucial aspect of auditory attention. Using a novel functional paradigm combined with quantitative MRI, we establish that human frequency-band-selective attention drives activation in both myeloarchitectonicallyestimated auditory core, and across the majority of tonotopically-mapped non-primary auditory cortex. The attentionally-driven best-frequency maps show strong concordance with sensorydriven maps in the same subjects across much of the temporal plane, with poor concordance in non-auditory areas. There is significantly greater activation across most of auditory cortex when best frequency is attended, versus ignored. Moreover, the single frequency bands that evoke the least activation and the frequency bands that elicit the least activation when attention is directed to them also correspond closely. Finally, the results demonstrate that there is spatial correspondence between the degree of myelination and the strength of the tonotopic signal across a number of regions in auditory cortex. Strong frequency preferences across tonotopically-mapped auditory cortex spatially correlate with R1-estimated myeloarchitecture, indicating shared functional and anatomical organization that may underlie intrinsic auditory regionalization. SignificancePerception is an active process especially sensitive to attentional state. Listeners direct auditory attention to track a violin's melody within an ensemble performance, or to follow a voice in a crowded cafe. Although diverse pathologies reduce quality of life by impacting such spectrallydirected auditory attention, its neurobiological bases are unclear. We demonstrate that human primary and non-primary auditory cortical activation is modulated by spectrally-directed attention in a manner that recapitulates its tonotopic sensory organization. Further, the graded activation profiles evoked by single frequency bands are correlated with attentionally-driven activation when these bands are presented in complex soundscapes. Finally, we observe a strong concordance in the degree of cortical myelination and the strength of tonotopic activation across several auditory cortical regions.

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“…Ultrahigh field MRI (≥7 Tesla) is a rapidly growing field that for the first time allows investigating structure-function correspondences at the meso- and micro-scale in the living human brain. Spatial precision is crucial in this context 34,71–73 .…”

Section: Discussionmentioning

confidence: 99%

LISA improves statistical analysis for fMRI

et al. 2018

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One of the principal goals in functional magnetic resonance imaging (fMRI) is the detection of local activation in the human brain. However, lack of statistical power and inflated false positive rates have recently been identified as major problems in this regard. Here, we propose a non-parametric and threshold-free framework called LISA to address this demand. It uses a non-linear filter for incorporating spatial context without sacrificing spatial precision. Multiple comparison correction is achieved by controlling the false discovery rate in the filtered maps. Compared to widely used other methods, it shows a boost in statistical power and allows to find small activation areas that have previously evaded detection. The spatial sensitivity of LISA makes it especially suitable for the analysis of high-resolution fMRI data acquired at ultrahigh field (≥7 Tesla).

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Body Topography Parcellates Human Sensory and Motor Cortex

Cited by 71 publications

References 96 publications

Multimodal finger-printing of the human precentral cortex forming the motor hand knob

Multimodal finger-printing of the human precentral cortex forming the motor hand knob

Extensive tonotopic mapping across auditory cortex is recapitulated by spectrally-directed attention, and systematically related to cortical myeloarchitecture

LISA improves statistical analysis for fMRI

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