Bolus compared with continuous infusion of microbubble contrast agent using real-time contrast harmonic imaging ultrasound in breast tumors

Saracco, Ariel; Aspelin, Peter; Leifland, Karin; Themudo, Raquel; Wilczek, Brigitte; Axelsson, Rimma

doi:10.1080/02841850903085576

Cited by 23 publications

(24 citation statements)

References 15 publications

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“…For microbubble, this administration approach is also better for achieving the ideal ultrasound contrast-enhanced imaging of tumor compared with the continuous infusion [40]. In addition, it also permitted convenient observation of the response to microbubble injection in mice, since no anesthetization was performed during the experiment.…”

Section: Discussionmentioning

confidence: 97%

Ultrasound triggered drug release from 10-hydroxycamptothecin-loaded phospholipid microbubbles for targeted tumor therapy in mice

Zheng

Ran

et al. 2012

Journal of Controlled Release

105

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Section: Discussionmentioning

confidence: 97%

Ultrasound triggered drug release from 10-hydroxycamptothecin-loaded phospholipid microbubbles for targeted tumor therapy in mice

Zheng

Ran

et al. 2012

Journal of Controlled Release

105

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“…After contrast agent injection, bubbles flushed in and out of malignant lesions faster than of benign lesions. Peak enhancement density is higher in malignant lesions [23]–[24]. The good correlation with MRI results has indicated that quantitative assessment is reliable [25]–[27].…”

Section: Introductionmentioning

confidence: 83%

Breast Contrast-Enhanced Ultrasound: Is a Scoring System Feasible? ----A Preliminary Study in China

Xiao

Yang

et al. 2014

PLoS ONE

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ObjectivesAlthough many studies about breast contrast-enhanced ultrasound had been conducted, clear diagnostic criteria for evaluating enhancement patterns are still lacking. This study aims to identify significant indicators for breast contrast-enhanced ultrasound and to establish an initial scoring system.Materials and MethodsTotally 839 patients were included in the study. This study was divided into two parts. 364 patients were included in part 1 while 475 in part 2. Conventional ultrasound and contrast-enhanced ultrasound were used to examine each lesion. Only the cases in part 2 were also examined by elastography. In part 1, Logistic regression analysis was performed to predict significant variables. A 5-point scoring system was developed based on the results. In part 2, the scoring system was used to evaluate all the breast lesions. To evaluate the diagnostic efficacy of the new scoring system, it was compared with the system established for elastography and conventional ultrasound (BI-RADS).ResultsThree independent variables, namely, lesion scope, margin, and shape were selected in the final step of the logistic regression analysis in part 1. In part 2, the area under the ROC (receiver operating characteristic) curve for the contrast-enhanced scoring system was 0.912. The difference in the diagnostic capabilities of the contrast-enhanced scoring system and elastography was not statistically significant (P = 0.17). The difference in the diagnostic capabilities of the contrast-enhanced scoring system and BI-RADS was statistically significant (P<0.001).ConclusionsThe contrast-enhanced patterns of benign and malignant breast tumors are different. The application of a 5-point scoring system for contrast-enhanced ultrasound is clinically promising.

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“…Evaluating time-intensity curves clear cut-off values have demonstrated that the bolus injection is the method of choice (14). But there is still a need for comparative studies in order to identify the correct injected dose.…”

Section: Discussionmentioning

confidence: 99%

Contrast-enhanced ultrasound using real-time contrast harmonic imaging in invasive breast cancer: comparison of enhancement dynamics with three different doses of contrast agent

et al. 2015

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Bolus compared with continuous infusion of microbubble contrast agent using real-time contrast harmonic imaging ultrasound in breast tumors

Abstract: CEUS using real-time harmonic imaging in order to evaluate breast tumors should be performed with bolus administration of contrast agent in order to achieve better intensity/time curve outcomes.

Cited by 23 publications

References 15 publications

Ultrasound triggered drug release from 10-hydroxycamptothecin-loaded phospholipid microbubbles for targeted tumor therapy in mice

Ultrasound triggered drug release from 10-hydroxycamptothecin-loaded phospholipid microbubbles for targeted tumor therapy in mice

Breast Contrast-Enhanced Ultrasound: Is a Scoring System Feasible? ----A Preliminary Study in China

Contrast-enhanced ultrasound using real-time contrast harmonic imaging in invasive breast cancer: comparison of enhancement dynamics with three different doses of contrast agent

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